Publications by authors named "Jake Chen"

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Shaping the glioblastoma microenvironment to enhance CAR-NK immunotherapy.
Emily Tang, Jake Y Chen

Front Immunol· December 2025

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GETgene-AI: a framework for prioritizing actionable cancer drug targets.
Adrian Gu, Jake Y Chen

Front Syst Biol· October 2025

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High-throughput screening for the identification of dual inhibitors of BRD4 and RIPK3 toward the development of small-molecule medical countermeasure agents against arsenicals.
Marina Fosso Yatchang, Ling Zhai, Omar Moukha-Chafiq, Bini Mathew, Fuad Al Abir, Jake Y Chen

SLAS Discov· September 2025

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NeSyDPP-4: discovering DPP-4 inhibitors for diabetes treatment with a neuro-symbolic AI approach.
Delower Hossain, Ehsan Saghapour, Jake Y Chen

Front Bioinform· July 2025

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CRISPR-Cas9 editing of variants in salivary gland epithelial cells to study Sjögren's disease pathogenesis.
Subhashis Ghosh, Qisheng Tu, Zoe Xiaofang Zhu, Sreelakshmi Panginikkod, Jake Jinkun Chen

Front Genome Ed· July 2025

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hERG-LTN: A New Paradigm for hERG Cardiotoxicity Prediction Using Neuro-Symbolic and Generative AI.
Md Delower Hossain, Fuad Al Abir, Jake Y Chen

Annu Int Conf IEEE Eng Med Biol Soc· July 2025

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Effects of Modified Messenger RNA of Adiponectin Delivered by Lipid Nanoparticles on Adipogenesis and Bone Metabolism In Vitro and In Vivo.
Ying Xie, Qian Ma, Jinghao Wang, Zoe Xiaofang Zhu, Rady E El-Araby, Jake Chen

Cells· June 2025

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Editorial: Outbreak oracles: how AI's journey through COVID-19 shapes future epidemic strategy.
Dmytro Chumachenko, Jasleen Kaur, Jake Y Chen

Front Artif Intell· June 2025

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Temporal GeneTerrain: advancing precision medicine through dynamic gene expression visualization.
Ehsan Saghapour, Rahul Sharma, Delower Hossain, Kevin Song, Zhandos Sembay, Jake Y Chen

Front Bioinform· June 2025

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KinoViz: A User-Friendly Web Application for High-Throughput Kinome Profiling Analysis and Visualization in Cancer Research.
Ehsan Saghapour, Joshua C Anderson, Jake Y Chen, Christopher D Willey

Res Sq· June 2025

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NeSyDPP4-QSAR: A Neuro-Symbolic AI Approach for Potent DPP-4-Inhibitor Discovery in Diabetes Treatment.
Delower Hossain, Ehsan Saghapour, Jake Y Chen

bioRxiv· April 2025

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Surgical considerations towards inducing proprioceptive feedback in dental implants.
Siddhartha Das, Subhashis Ghosh, Qisheng Tu, Zoe Xiaofang Zhu, Jake Jinkun Chen

Sci Rep· April 2025

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Development of a Machine Learning Tool for Home-Based Assessment of Periodontitis.
Zoe Xiaofang Zhu, Xingwen Wu, Lifang Zhu, Naciye Uzel, Athanasios Zavras, Jake Chen

medRxiv· March 2025

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Prevent and Reverse Metabolic Dysfunction-Associated Steatohepatitis and Hepatic Fibrosis via mRNA-Mediated Liver-Specific Antibody Therapy.
Chenshuang Zhang, Yilong Teng, Xin Bai, Maoping Tang, William Stewart, Jake Jinkun Chen

ACS Nano· December 2024

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AI-readiness for Biomedical Data: Bridge2AI Recommendations.
Timothy Clark, Harry Caufield, Jillian A Parker, Sadnan Al Manir, Edilberto Amorim, Jake Y Chen

bioRxiv· November 2024

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A PERTURBATION CELL ATLAS OF HUMAN INDUCED PLURIPOTENT STEM CELLS.
Sami Nourreddine, Yesh Doctor, Amir Dailamy, Antoine Forget, Yi-Hung Lee, Jake Y Chen

bioRxiv· November 2024

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Toden-E: Topology-Based and Density-Based Ensembled Clustering for the Development of Super-PAG in Functional Genomics using PAG Network and LLM.
Qi Li, Cody Nichols, Robert S Welner, Jake Y Chen, Wei-Shinn Ku

bioRxiv· October 2024

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Mondrian Abstraction and Language Model Embeddings for Differential Pathway Analysis.
Fuad Al Abir, Jake Y Chen

bioRxiv· August 2024

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Establishment of a novel cellular model for Alzheimer's disease in vitro studies.
Rady E El-Araby, Komal Wasif, Rebecca Johnson, Qisheng Tu, Tarek Aboushousha, Jake Chen

Exp Neurol· August 2024

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Pharmacogenomics of coronary artery response to intravenous gamma globulin in kawasaki disease.
Sadeep Shrestha, Howard W Wiener, Sabrina Chowdhury, Hidemi Kajimoto, Vinodh Srinivasasainagendra, Jake Y Chen

NPJ Genom Med· May 2024

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Cell Maps for Artificial Intelligence: AI-Ready Maps of Human Cell Architecture from Disease-Relevant Cell Lines.
Timothy Clark, Jillian Mohan, Leah Schaffer, Kirsten Obernier, Sadnan Al Manir, Jake Chen

bioRxiv· May 2024

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Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes.
Rady E El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li, Jake Chen

Aging Dis· May 2024

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Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system.
Radomir M Slominski, Jake Y Chen, Chander Raman, Andrzej T Slominski

Proc Natl Acad Sci U S A· April 2024

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Explorative Discovery of Gene Signatures and Clinotypes in Glioblastoma Cancer Through GeneTerrain Knowledge Map Representation.
Ehsan Saghapour, Zongliang Yue, Rahul Sharma, Sidharth Kumar, Zhandos Sembay, Jake Y Chen

bioRxiv· April 2024

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PAGER-scFGA: unveiling cell functions and molecular mechanisms in cell trajectories through single-cell functional genomics analysis.
Fengyuan Huang, Robert S Welner, Jake Y Chen, Zongliang Yue

Front Bioinform· April 2024

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