Publications by authors named "James D Lear"

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Correction: Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction.
Amanda E Siglin, Shangjin Sun, Jeffrey K Moore, Sarah Tan, Martin Poenie, James D Lear

PLoS One· June 2024

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Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein.
Alexei L Polishchuk, Lidia Cristian, Lawrence H Pinto, James D Lear, William F DeGrado

Biochim Biophys Acta· April 2014

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Dynein and dynactin leverage their bivalent character to form a high-affinity interaction.
Amanda E Siglin, Shangjin Sun, Jeffrey K Moore, Sarah Tan, Martin Poenie, James D Lear

PLoS One· October 2013

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Computational design of a self-assembling β-peptide oligomer.
Ivan V Korendovych, Yong Ho Kim, Andrew H Ryan, James D Lear, William F Degrado

Org Lett· November 2010

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De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex.
Ivan V Korendovych, Alessandro Senes, Yong Ho Kim, James D Lear, H Christopher Fry

J Am Chem Soc· November 2010

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A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein.
Alexei L Polishchuk, James D Lear, Chunlong Ma, Robert A Lamb, Lawrence H Pinto

Biochemistry· November 2010

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Experimental and computational evaluation of forces directing the association of transmembrane helices.
Yao Zhang, Daniel W Kulp, James D Lear, William F DeGrado

J Am Chem Soc· August 2009

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Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel.
Chunlong Ma, Alexei L Polishchuk, Yuki Ohigashi, Amanda L Stouffer, Arne Schön, James D Lear

Proc Natl Acad Sci U S A· July 2009

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Biochemical and structural characterization of the Pak1-LC8 interaction.
Christine M Lightcap, Shangjin Sun, James D Lear, Ulrich Rodeck, Tatyana Polenova

J Biol Chem· October 2008

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Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays.
Karen A McAllister, Hongling Zou, Frank V Cochran, Gretchen M Bender, Alessandro Senes, James D Lear

J Am Chem Soc· September 2008

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Factor XI homodimer structure is essential for normal proteolytic activation by factor XIIa, thrombin, and factor XIa.
Wenman Wu, Dipali Sinha, Sergei Shikov, Calvin K Yip, Thomas Walz, James D Lear

J Biol Chem· July 2008

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The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.
Amanda L Stouffer, Chunlong Ma, Lidia Cristian, Yuki Ohigashi, Robert A Lamb, James D Lear

Structure· July 2008

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Effect of divalent cations on the structure of the antibiotic daptomycin.
Steven W Ho, David Jung, Jennifer R Calhoun, James D Lear, Mark Okon

Eur Biophys J· April 2008

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Structural basis for ligand-mediated mouse GITR activation.
Zhaocai Zhou, Yukiko Tone, Xiaomin Song, Keiji Furuuchi, James D Lear

Proc Natl Acad Sci U S A· January 2008

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Computational design of peptides that target transmembrane helices.
Hang Yin, Joanna S Slusky, Bryan W Berger, Robin S Walters, Gaston Vilaire, James D Lear

Science· March 2007

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Design of a functional membrane protein by engineering a heme-binding site in glycophorin A.
Jeanine M Cordova, Pamela L Noack, Simon A Hilcove, James D Lear, Giovanna Ghirlanda

J Am Chem Soc· January 2007

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Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.
Hang Yin, Rustem I Litvinov, Gaston Vilaire, Hua Zhu, Wei Li, James D Lear

J Biol Chem· December 2006

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Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides.
Benjamin North, Lidia Cristian, Xiaoran Fu Stowell, James D Lear, Jeffrey G Saven

J Mol Biol· June 2006

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Polar networks control oligomeric assembly in membranes.
Chad D Tatko, Vikas Nanda, James D Lear, William F Degrado

J Am Chem Soc· April 2006

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Relationship between salt-bridge identity and 14-helix stability of beta3-peptides in aqueous buffer.
Danielle A Guarracino, Hyojin R Chiang, Tereece N Banks, James D Lear, Michael E Hodsdon

Org Lett· March 2006

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Design of amphiphilic protein maquettes: controlling assembly, membrane insertion, and cofactor interactions.
Bohdana M Discher, Dror Noy, Joseph Strzalka, Shixin Ye, Christopher C Moser, James D Lear

Biochemistry· September 2005

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Factor XIa dimer in the activation of factor IX.
Dipali Sinha, Mariola Marcinkiewicz, James D Lear, Peter N Walsh

Biochemistry· August 2005

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Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability.
Lidia Cristian, Vikas Nanda, James D Lear, William F DeGrado

J Mol Biol· May 2005

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Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function.
Amanda L Stouffer, Vikas Nanda, James D Lear, William F DeGrado

J Mol Biol· March 2005

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A push-pull mechanism for regulating integrin function.
Wei Li, Douglas G Metcalf, Roman Gorelik, Renhao Li, Neal Mitra, James D Lear

Proc Natl Acad Sci U S A· February 2005

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