Publications by authors named "James Fells"

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Discovery of macrocyclic HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Wensheng Yu, James Fells, Dane Clausen, Jian Liu, Daniel J Klein

Bioorg Med Chem Lett· September 2021

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Discovery of Ethyl Ketone-Based Highly Selective HDACs 1, 2, 3 Inhibitors for HIV Latency Reactivation with Minimum Cellular Potency Serum Shift and Reduced hERG Activity.
Wensheng Yu, Jian Liu, Dane Clausen, Younong Yu, Joseph L Duffy, James I Fells

J Med Chem· April 2021

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Identification of free fatty acid receptor 2 agonists using virtual screening.
James I Fells, Xi Ai, Adam Weinglass, Wen Feng, Ying Lei

Bioorg Med Chem Lett· November 2020

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Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir.
Dane J Clausen, Jian Liu, Wensheng Yu, Joseph L Duffy, Christine C Chung, James Fells

Bioorg Med Chem Lett· September 2020

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Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation.
Wensheng Yu, Jian Liu, Younong Yu, Vivian Zhang, Dane Clausen, James Fells

Bioorg Med Chem Lett· July 2020

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Selective Class I HDAC Inhibitors Based on Aryl Ketone Zinc Binding Induce HIV-1 Protein for Clearance.
Jian Liu, Joseph Kelly, Wensheng Yu, Dane Clausen, Younong Yu, James Fells

ACS Med Chem Lett· July 2020

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Performance of multiple docking and refinement methods in the pose prediction D3R prospective Grand Challenge 2016.
Xavier Fradera, Andreas Verras, Yuan Hu, Deping Wang, Hongwu Wang, James I Fells

J Comput Aided Mol Des· January 2018

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Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort.
Ying-Duo Gao, Yuan Hu, Alejandro Crespo, Deping Wang, Kira A Armacost, James I Fells

J Comput Aided Mol Des· January 2018

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Informing the Selection of Screening Hit Series with in Silico Absorption, Distribution, Metabolism, Excretion, and Toxicity Profiles.
John M Sanders, Douglas C Beshore, J Christopher Culberson, James I Fells, Jason E Imbriglio

J Med Chem· August 2017

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Alternative core development around the tetracyclic indole class of HCV NS5A inhibitors.
Ling Tong, Wensheng Yu, Craig A Coburn, Peter T Meinke, Anilkumar G Nair, James Fells

Bioorg Med Chem Lett· October 2016

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Discovery of potent macrocyclic HCV NS5A inhibitors.
Wensheng Yu, Bancha Vibulbhan, Stuart B Rosenblum, Gregory S Martin, A Samuel Vellekoop, James Fells

Bioorg Med Chem Lett· August 2016

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Discovery of fused tricyclic core containing HCV NS5A inhibitors with pan-genotype activity.
Wensheng Yu, Craig A Coburn, De-Yi Yang, Peter T Meinke, Michael Wong, James Fells

Bioorg Med Chem Lett· July 2016

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Combined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.
Renukadevi Patil, Erzsébet Szabó, James I Fells, Andrea Balogh, Keng G Lim

Chem Biol· February 2015

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Structural determinants of the transient receptor potential 1 (TRPV1) channel activation by phospholipid analogs.
Sara L Morales-Lázaro, Barbara Serrano-Flores, Itzel Llorente, Enrique Hernández-García, Ricardo González-Ramírez, James Fells

J Biol Chem· August 2014

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Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.
Renukadevi Patil, James I Fells, Erzsébet Szabó, Keng G Lim, Derek D Norman

J Med Chem· August 2014

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Targeting the hydrophobic pocket of autotaxin with virtual screening of inhibitors identifies a common aromatic sulfonamide structural motif.
James I Fells, Sue Chin Lee, Derek D Norman, Ryoko Tsukahara, Jason R Kirby

FEBS J· February 2014

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Hits of a high-throughput screen identify the hydrophobic pocket of autotaxin/lysophospholipase D as an inhibitory surface.
James I Fells, Sue Chin Lee, Yuko Fujiwara, Derek D Norman, Keng Gat Lim

Mol Pharmacol· September 2013

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Mitigation of radiation injury by selective stimulation of the LPA(2) receptor.
Gyöngyi N Kiss, Sue-Chin Lee, James I Fells, Jianxiong Liu, William J Valentine

Biochim Biophys Acta· January 2013

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Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.
Gyöngyi N Kiss, James I Fells, Renuka Gupte, Sue-Chin Lee, Jianxiong Liu

Mol Pharmacol· December 2012

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Controlling cancer through the autotaxin-lysophosphatidic acid receptor axis.
Mari Gotoh, Yuko Fujiwara, Junming Yue, Jianxiong Liu, SueChin Lee, James Fells

Biochem Soc Trans· February 2012

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Benzyl and naphthalene methylphosphonic acid inhibitors of autotaxin with anti-invasive and anti-metastatic activity.
Renuka Gupte, Renukadevi Patil, Jianxiong Liu, Yaohong Wang, Sue C Lee, James Fells

ChemMedChem· May 2011

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2D binary QSAR modeling of LPA3 receptor antagonism.
James I Fells, Ryoko Tsukahara, Jianxiong Liu, Gabor Tigyi, Abby L Parrill

J Mol Graph Model· June 2010

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Structure-based drug design identifies novel LPA3 antagonists.
James I Fells, Ryoko Tsukahara, Jianxiong Liu, Gabor Tigyi, Abby L Parrill

Bioorg Med Chem· November 2009

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Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo.
Honglu Zhang, Xiaoyu Xu, Joanna Gajewiak, Ryoko Tsukahara, Yuko Fujiwara, James I Fells

Cancer Res· July 2009

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Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.
Jesica R Williams, Anna L Khandoga, Pankaj Goyal, James I Fells, Donna H Perygin

J Biol Chem· June 2009

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