Publications by authors named "Adam Weinglass"

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Avoiding Misreading during Genetic Reprogramming in mRNA Display.
Gopal K Dubey, Peng-Hsun Chase Chen, Sabrina E Iskandar, Naga Garikiparthy, Hratch J Zokian, Adam Weinglass

Chembiochem· June 2025

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Antibacterial macrocyclic peptides reveal a distinct mode of BamA inhibition.
Morgan E Walker, Wei Zhu, Janine H Peterson, Hao Wang, Jon Patteson, Adam Weinglass

Nat Commun· April 2025

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Analysis and Prediction of Chymotrypsin Substrate Preferences through Large Data Acquisition with Target-Free mRNA Display.
Sabrina E Iskandar, Lindsey Guan, Rumit Maini, Christopher J Hipolito, Congliang Sun, Adam Weinglass

Chembiochem· February 2025

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A non-canonical mechanism of GPCR activation.
Alexander S Powers, Aasma Khan, Joseph M Paggi, Naomi R Latorraca, Sarah Souza, Adam B Weinglass

Nat Commun· November 2024

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A non-canonical mechanism of GPCR activation.
Alexander S Powers, Aasma Khan, Joseph M Paggi, Naomi R Latorraca, Sarah Souza, Adam B Weinglass

bioRxiv· August 2023

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Label-free LC-MS based assay to characterize small molecule compound binding to cells.
Menglin Chen, Zhengrong Zhu, Tom Wisniewski, Xiaoping Zhang, David G McLaren, Adam Weinglass

SLAS Discov· October 2022

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High-Throughput Screening to Identify Small Molecules That Selectively Inhibit APOL1 Protein Level in Podocytes.
Jonathan Choy, Yanqing Kan, Steve Cifelli, Josephine Johnson, Michelle Chen, Adam Weinglass

SLAS Discov· October 2021

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Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
Jinlong Jiang, Fa-Xiang Ding, Xiaoyan Zhou, Thomas J Bateman, Shuzhi Dong, Adam Weinglass

J Med Chem· June 2021

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Identification of free fatty acid receptor 2 agonists using virtual screening.
James I Fells, Xi Ai, Adam Weinglass, Wen Feng, Ying Lei

Bioorg Med Chem Lett· November 2020

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Cell-Based In Vitro Assay Automation: Balancing Technology and Data Reproducibility/Predictability.
Brande Thomas-Fowlkes, Steven Cifelli, Sarah Souza, Richard Visconti, Alice Struck, Adam Weinglass

SLAS Technol· June 2020

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.
Barbara Pio, Harry R Chobanian, Yan Guo, Hubert Josien, William K Hagmann, Adam B Weinglass

Bioorg Med Chem Lett· July 2019

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Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs.
Helen Y Chen, Christopher W Plummer, Dong Xiao, Harry R Chobanian, Duane DeMong, Adam B Weinglass

ACS Med Chem Lett· July 2018

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GPR40 partial agonists and AgoPAMs: Differentiating effects on glucose and hormonal secretions in the rodent.
Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Boonlert Cheewatrakoolpong, Adam B Weinglass

PLoS One· November 2017

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GPR40 partial agonist MK-2305 lower fasting glucose in the Goto Kakizaki rat via suppression of endogenous glucose production.
Corin Miller, Michele J Pachanski, Melissa E Kirkland, Daniel T Kosinski, Joel Mane, Adam B Weinglass

PLoS One· September 2017

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GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.
Santhosh Satapati, Ying Qian, Margaret S Wu, Aleksandr Petrov, Ge Dai, Adam Weinglass

J Lipid Res· August 2017

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GPR40 reduces food intake and body weight through GLP-1.
Judith N Gorski, Michele J Pachanski, Joel Mane, Christopher W Plummer, Sarah Souza, Adam B Weinglass

Am J Physiol Endocrinol Metab· July 2017

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Structural basis for the cooperative allosteric activation of the free fatty acid receptor GPR40.
Jun Lu, Noel Byrne, John Wang, Gerard Bricogne, Frank K Brown, Adam B Weinglass

Nat Struct Mol Biol· July 2017

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Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Shuzhi Dong, Kelsey VanGelder, Zhi-Cai Shi, Yang Yu, Zhicai Wu, Adam Weinglass

Bioorg Med Chem Lett· June 2017

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Design and Synthesis of Novel, Selective GPR40 AgoPAMs.
Christopher W Plummer, Matthew J Clements, Helen Chen, Murali Rajagopalan, Hubert Josien, Adam B Weinglass

ACS Med Chem Lett· February 2017

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Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists.
Jason M Cox, Hong D Chu, Mariappan V Chelliah, John S Debenham, Keith Eagen, Adam Weinglass

ACS Med Chem Lett· January 2017

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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Nardos Teumelsan, Jessica Frie, Adam Weinglass

ACS Med Chem Lett· July 2015

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GPR40 (FFAR1) - Combined Gs and Gq signaling in vitro is associated with robust incretin secretagogue action ex vivo and in vivo.
Maria Hauge, Marie A Vestmar, Anna S Husted, Jeppe P Ekberg, Michael J Wright, Adam B Weinglass

Mol Metab· January 2015

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Technologies for transporter drug discovery.
Adam B Weinglass, Maria L Garcia, Gregory L Kaczorowski

Channels (Austin)· July 2011

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A KV2.1 gating modifier binding assay suitable for high throughput screening.
William A Schmalhofer, Kevin S Ratliff, Adam Weinglass, Gregory J Kaczorowski, Maria L Garcia

Channels (Austin)· November 2009

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ProTx-II, a selective inhibitor of NaV1.7 sodium channels, blocks action potential propagation in nociceptors.
William A Schmalhofer, Jeffrey Calhoun, Rachel Burrows, Timothy Bailey, Martin G Kohler, Adam B Weinglass

Mol Pharmacol· November 2008

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