Publications by authors named "Jessica Frie"

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Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator.
Michael T Rudd, Peter J Manley, Barbara Hanney, Zhaoyang Meng, Youheng Shu, Jessica L Frie

ACS Med Chem Lett· August 2023

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Improvement of hERG-ROMK index of spirocyclic ROMK inhibitors through scaffold optimization and incorporation of novel pharmacophores.
Shuzhi Dong, Kelsey VanGelder, Zhi-Cai Shi, Yang Yu, Zhicai Wu, Jessica Frie

Bioorg Med Chem Lett· June 2017

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The design and synthesis of novel spirocyclic heterocyclic sulfone ROMK inhibitors as diuretics.
Harry R Chobanian, Yan Guo, Barbara Pio, Haifeng Tang, Nardos Teumelsan, Jessica Frie

Bioorg Med Chem Lett· February 2017

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Differentiation of ROMK potency from hERG potency in the phenacetyl piperazine series through heterocycle incorporation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Reynalda K de Jesus, Nardos Teumelsan, Jessica Frie

Bioorg Med Chem Lett· May 2016

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Discovery of a Potent and Selective ROMK Inhibitor with Pharmacokinetic Properties Suitable for Preclinical Evaluation.
Shawn P Walsh, Aurash Shahripour, Haifeng Tang, Nardos Teumelsan, Jessica Frie

ACS Med Chem Lett· July 2015

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A hypervalent iodine-induced double annulation enables a concise synthesis of the pentacyclic core structure of the cortistatins.
Jessica L Frie, Christopher S Jeffrey, Erik J Sorensen

Org Lett· December 2009

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Molecular modeling aided design of nicotinic acid receptor GPR109A agonists.
Qiaolin Deng, Jessica L Frie, Daria M Marley, Richard T Beresis, Ning Ren

Bioorg Med Chem Lett· September 2008

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Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
Steven L Colletti, Jessica L Frie, Elizabeth C Dixon, Suresh B Singh, Bernard K Choi

J Med Chem· January 2003

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