Publications by authors named "James Fossetta"

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A High-Throughput Time-Resolved Fluorescence Energy Transfer Assay to Screen for Modulators of RGS7/Gβ5/R7BP Complex.
Brian S Muntean, Dipak N Patil, Franck Madoux, James Fossetta, Louis Scampavia

Assay Drug Dev Technol· April 2018

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Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.
Jennifer Hanisak, W Michael Seganish, William T McElroy, Haiquin Tang, Rui Zhang, James Fossetta

Bioorg Med Chem Lett· September 2016

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Initial optimization and series evolution of diaminopyrimidine inhibitors of interleukin-1 receptor associated kinase 4.
W Michael Seganish, William T McElroy, R Jason Herr, Stephanie Brumfield, William J Greenlee, James Fossetta

Bioorg Med Chem Lett· August 2015

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Discovery and Structure Enabled Synthesis of 2,6-Diaminopyrimidin-4-one IRAK4 Inhibitors.
W Michael Seganish, Thierry O Fischmann, Brad Sherborne, Julius Matasi, Brian Lavey, James Fossetta

ACS Med Chem Lett· August 2015

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Potent and Selective Amidopyrazole Inhibitors of IRAK4 That Are Efficacious in a Rodent Model of Inflammation.
William T McElroy, Zheng Tan, Ginny Ho, Sunil Paliwal, Guoqing Li, James Fossetta

ACS Med Chem Lett· June 2015

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Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres.
Dong Xiao, Xiaohong Zhu, Michael Sofolarides, Sylvia Degrado, Ning Shao, James Fossetta

Bioorg Med Chem Lett· August 2014

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Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
Dong Xiao, Anandan Palani, Xianhai Huang, Michael Sofolarides, Wei Zhou, James Fossetta

Bioorg Med Chem Lett· June 2013

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Discovery of a Potent Dihydrooxadiazole Series of Non-ATP-Competitive MK2 (MAPKAPK2) Inhibitors.
Jun Qin, Pawan Dhondi, Xianhai Huang, Robert Aslanian, James Fossetta

ACS Med Chem Lett· February 2012

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A three-step protocol for lead optimization: quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors.
Xianhai Huang, Xiaohong Zhu, Xiao Chen, Wei Zhou, Dong Xiao, James Fossetta

Bioorg Med Chem Lett· January 2012

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Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors.
Ashwin U Rao, Dong Xiao, Xianhai Huang, Wei Zhou, James Fossetta

Bioorg Med Chem Lett· January 2012

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3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.
Purakkattle Biju, Arthur G Taveras, Younong Yu, Junying Zheng, R William Hipkin, James Fossetta

Bioorg Med Chem Lett· March 2009

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Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists.
Younong Yu, Michael P Dwyer, Jianping Chao, Cynthia Aki, Jianhua Chao, James Fossetta

Bioorg Med Chem Lett· February 2008

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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists.
Purakkattle Biju, Arthur Taveras, Younong Yu, Junying Zheng, Jianhua Chao, James Fossetta

Bioorg Med Chem Lett· January 2008

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Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.
Waldemar Gonsiorek, Xuedong Fan, David Hesk, James Fossetta, Hongchen Qiu

J Pharmacol Exp Ther· August 2007

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Discovery of 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(5- methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobut-1-enylamino}benzamide (SCH 527123): a potent, orally bioavailable CXCR2/CXCR1 receptor antagonist.
Michael P Dwyer, Younong Yu, Jianping Chao, Cynthia Aki, Jianhua Chao, James Fossetta

J Med Chem· December 2006

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Characterization of peripheral human cannabinoid receptor (hCB2) expression and pharmacology using a novel radioligand, [35S]Sch225336.
Waldemar Gonsiorek, David Hesk, Shu-Cheng Chen, David Kinsley, Jay S Fine, James Fossetta

J Biol Chem· September 2006

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Pharmacological characterization of human S1P4 using a novel radioligand, [4,5-3H]-dihydrosphingosine-1-phosphate.
James Fossetta, Gregory Deno, Waldemar Gonsiorek, Xuedong Fan, Brian Lavey

Br J Pharmacol· July 2004

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Pharmacological analysis of calcium responses mediated by the human A3 adenosine receptor in monocyte-derived dendritic cells and recombinant cells.
James Fossetta, James Jackson, Gregory Deno, Xuedong Fan, Xixuan Karen Du

Mol Pharmacol· February 2003

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