Publications by authors named "Hongchen Qiu"

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Design, Synthesis, and T Cell Checkpoint Combination Potential Of First-In-Class DGKα/ζ Inhibitor BMS-986408.
Denise C Grünenfelder, Upender Velaparthi, Jayakumar S Warrier, Louis Chupak, Chetan Padmakar Darne, Hongchen Qiu

J Med Chem· October 2025

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Discovery of BMS-986408, a First-In-Class Dual DGKα and DGKζ Inhibitor that Unleashes PD-1 Checkpoint and CAR T-cell Immunotherapies.
Michael Wichroski, Si-Qi Liu, Lauren M Zasadil, Joseph L Benci, Patrick C Gedeon, Hongchen Qiu

Cancer Immunol Res· September 2025

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DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity.
Michael Wichroski, Joseph Benci, Si-Qi Liu, Louis Chupak, Jie Fang, Hongchen Qiu

Sci Transl Med· October 2023

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Discovery of MK-8318, a Potent and Selective CRTh2 Receptor Antagonist for the Treatment of Asthma.
Xianhai Huang, Jason Brubaker, Wei Zhou, Purakkattle J Biju, Li Xiao, Hongchen Qiu

ACS Med Chem Lett· July 2018

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The synthesis of 2,3,6-trisubstituted 1-oxo-1,2-dihydroisoquinolines as potent CRTh antagonists.
Xianhai Huang, Ashwin Rao, Wei Zhou, Robert Aslanian, Ravi Nargund, Hongchen Qiu

Bioorg Med Chem Lett· December 2017

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Identification of highly potent and selective PI3Kδ inhibitors.
David Marcoux, Lan-Ying Qin, Zheming Ruan, Qing Shi, Qian Ruan, Hongchen Qiu

Bioorg Med Chem Lett· July 2017

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The effect of cadmium on the growth and antioxidant response for freshwater algae Chlorella vulgaris.
Jinfeng Cheng, Hongchen Qiu, Zhaoyang Chang, Zaimin Jiang, Wenke Yin

Springerplus· September 2016

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Isolation, structure elucidation and antibacterial activity of a new tetramic acid, ascosetin.
John G Ondeyka, Scott K Smith, Deborah L Zink, Francisca Vicente, Angela Basilio, Hongchen Qiu

J Antibiot (Tokyo)· July 2014

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Quality by design (QbD) of amide isosteres: 5,5-Disubstituted isoxazolines as potent CRTh2 antagonists with favorable pharmacokinetic and drug-like properties.
Dong Xiao, Xiaohong Zhu, Younong Yu, Ning Shao, Jie Wu, Hongchen Qiu

Bioorg Med Chem Lett· March 2014

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Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 2.
Stephanie Brumfield, Julius J Matasi, Deen Tulshian, Michael Czarniecki, William Greenlee, Hongchen Qiu

Bioorg Med Chem Lett· December 2011

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Synthesis and SAR development of novel P2X7 receptor antagonists for the treatment of pain: part 1.
Julius J Matasi, Stephanie Brumfield, Deen Tulshian, Michael Czarnecki, William Greenlee, Hongchen Qiu

Bioorg Med Chem Lett· June 2011

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Synthesis and structure-activity relationships of heteroaryl substituted-3,4-diamino-3-cyclobut-3-ene-1,2-dione CXCR2/CXCR1 receptor antagonists.
Younong Yu, Michael P Dwyer, Jianping Chao, Cynthia Aki, Jianhua Chao, Hongchen Qiu

Bioorg Med Chem Lett· February 2008

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3,4-Diamino-2,5-thiadiazole-1-oxides as potent CXCR2/CXCR1 antagonists.
Purakkattle Biju, Arthur Taveras, Younong Yu, Junying Zheng, Jianhua Chao, Hongchen Qiu

Bioorg Med Chem Lett· January 2008

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Pharmacological characterization of Sch527123, a potent allosteric CXCR1/CXCR2 antagonist.
Waldemar Gonsiorek, Xuedong Fan, David Hesk, James Fossetta, Hongchen Qiu

J Pharmacol Exp Ther· August 2007

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Identification of full, partial and inverse CC chemokine receptor 3 agonists using [35S]GTPgammaS binding.
Yuntao Wan, James P Jakway, Hongchen Qiu, Himanshu Shah, Charles G Garlisi

Eur J Pharmacol· December 2002

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