Publications by authors named "James P. Edwards"

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A Novel Small Molecule Allosteric Inhibitor of IL-17A from a DNA-Encoded Library.
Marcos E Milla, Jonathan M Blevitt, Steven D Goldberg, Anthony A Armstrong, Katherine Y Blain, James P Edwards

ACS Med Chem Lett· November 2025

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Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis.
Olaf Kinzel, Steven D Goldberg, Maxwell D Cummings, Christian Gege, Christoph Steeneck, James P Edwards

J Med Chem· April 2025

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Toward Dose Prediction at Point of Design.
Dries Van Rompaey, Siladitya Ray Chaudhuri, Mazen Ahmad, Justin Cisar, An Van Den Bergh, James P Edwards

J Med Chem· December 2024

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Identification of isoquinolinone DHODH inhibitor isosteres.
Lindsey G DeRatt, Zhuming Zhang, E Christine Pietsch, Justin Cisar, Aihua Wang, James P Edwards

Bioorg Med Chem Lett· November 2024

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Preclinical efficacy of the potent, selective menin-KMT2A inhibitor JNJ-75276617 (bleximenib) in KMT2A- and NPM1-altered leukemias.
Min Chul Kwon, Jan Willem Thuring, Olivier Querolle, Xuedong Dai, Tinne Verhulst, James P Edwards

Blood· September 2024

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Discovery of JNJ-74856665: A Novel Isoquinolinone DHODH Inhibitor for the Treatment of AML.
Lindsey G DeRatt, Zhuming Zhang, Christine Pietsch, Justin S Cisar, Xiaochun Zhang, James P Edwards

J Med Chem· July 2024

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Discovery of Alternative Binding Poses through Fragment-Based Identification of DHODH Inhibitors.
Lindsey G DeRatt, E Christine Pietsch, Justin S Cisar, Edgar Jacoby, Faraz Kazmi, James P Edwards

ACS Med Chem Lett· March 2024

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Monte Carlo generation of localized particle trajectories.
Ivan Ahumada, James P Edwards

Phys Rev E· December 2023

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Development of small molecule inhibitors of natural killer group 2D receptor (NKG2D).
Jocelyn Wang, Kohki M Nakafuku, Jeannie Ziff, Christine F Gelin, Hadi Gholami, James P Edwards

Bioorg Med Chem Lett· November 2023

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Identification of small-molecule protein-protein interaction inhibitors for NKG2D.
Aaron A Thompson, Michael B Harbut, Pei-Pei Kung, Nathan K Karpowich, Jeffrey D Branson, James P Edwards

Proc Natl Acad Sci U S A· May 2023

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Mark S Tichenor, John J M Wiener, Navin L Rao, Genesis M Bacani, Jianmei Wei, James P Edwards

J Med Chem· November 2022

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-Heterocyclic 3-Pyridyl Carboxamide Inhibitors of DHODH for the Treatment of Acute Myelogenous Leukemia.
Justin S Cisar, Christine Pietsch, Lindsey G DeRatt, Edgar Jacoby, Faraz Kazmi, James P Edwards

J Med Chem· August 2022

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Resummation for quantum propagators in bounded spaces.
James P Edwards, Víctor A González-Domínguez, Idrish Huet, Maria Anabel Trejo

Phys Rev E· June 2022

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Discovery of Highly Potent and Selective IRAK1 Degraders to Probe Scaffolding Functions of IRAK1 in ABC DLBCL.
Liqiang Fu, Jing Zhang, Bin Shen, Linglong Kong, Yingtao Liu, James P Edwards

J Med Chem· August 2021

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Gut-Restricted Selective Cyclooxygenase-2 (COX-2) Inhibitors for Chemoprevention of Colorectal Cancer.
Zhuming Zhang, Avijit Ghosh, Peter J Connolly, Peter King, Thomas Wilde, James P Edwards

J Med Chem· August 2021

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
Mark S Tichenor, John J M Wiener, Navin L Rao, Charlotte Pooley Deckhut, J Kent Barbay, James P Edwards

ACS Med Chem Lett· May 2021

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Assessing IRAK4 Functions in ABC DLBCL by IRAK4 Kinase Inhibition and Protein Degradation.
Jing Zhang, Liqiang Fu, Bin Shen, Yingtao Liu, Wenqian Wang, James P Edwards

Cell Chem Biol· December 2020

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A carboxylic acid isostere screen of the DHODH inhibitor Brequinar.
Lindsey G DeRatt, E Christine Pietsch, Alexandra Tanner, Paul Shaffer, Edgar Jacoby, James P Edwards

Bioorg Med Chem Lett· November 2020

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Selective inhibition of peripheral cathepsin S reverses tactile allodynia following peripheral nerve injury in mouse.
William A Eckert, John J M Wiener, Hui Cai, Michael K Ameriks, Jian Zhu, James P Edwards

Eur J Pharmacol· August 2020

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Discovery and optimization of new oxadiazole substituted thiazole RORγt inverse agonists through a bioisosteric amide replacement approach.
Christoph Steeneck, Christian Gege, Olaf Kinzel, Michael Albers, Gerald Kleymann, James P Edwards

Bioorg Med Chem Lett· June 2020

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Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Christian Gege, Michael Albers, Olaf Kinzel, Gerald Kleymann, Thomas Schlüter, James P Edwards

Bioorg Med Chem Lett· June 2020

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Discovery of a Gut-Restricted JAK Inhibitor for the Treatment of Inflammatory Bowel Disease.
Kristi A Leonard, Lisa A Madge, Paul J Krawczuk, Aihua Wang, Kevin D Kreutter, James P Edwards

J Med Chem· March 2020

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Immunological characterization of HM5023507, an orally active PI3Kδ/γ inhibitor.
Yu Cai, Jun Yu, Ping Ren, Jianlin He, Zhipeng Wu, James P Edwards

Pharmacol Res Perspect· February 2020

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3-Substituted Quinolines as RORγt Inverse Agonists.
Virginia M Tanis, Hariharan Venkatesan, Maxwell D Cummings, Michael Albers, J Kent Barbay, James P Edwards

Bioorg Med Chem Lett· June 2019

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Discovery, Optimization, and Evaluation of Potent and Highly Selective PI3Kγ-PI3Kδ Dual Inhibitors.
Hong Jia, Guangxiu Dai, Weiguo Su, Kun Xiao, Jianyang Weng, James P Edwards

J Med Chem· May 2019

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