Publications by authors named "Jamie Fletcher"

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High-throughput 3D engineered paediatric tumour models for precision medicine.
MoonSun Jung, Valentina Poltavets, Joanna N Skhinas, Gabor Tax, Alvin Kamili, Jamie I Fletcher

Mol Syst Biol· December 2025

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Second-Generation AURKA-Targeting PROTACs: Structural Optimization toward in Vivo Degradation in Neuroblastoma.
Simon Krols, Muhammad Rishfi, Fien Martens, Anouk Van Hauwermeiren, Ellen Sanders, Jamie I Fletcher

J Med Chem· November 2025

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Inclusion of JNK-independent drugs within multiagent chemotherapy improves response in relapsed high-risk neuroblastoma.
Jeremy Z R Han, Monica Phimmachanh, Jordan F Hastings, King Ho Leong, Boaz H Ng, Jamie I Fletcher

Sci Adv· November 2025

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NONO Maintains SREBP-Regulated Cholesterol Biosynthesis via RNA Binding in Neuroblastoma.
Song Zhang, Hayley Ingram, Jack Cooper, Alina Naveed, Stefan G Kathman, Jamie I Fletcher

FASEB J· September 2025

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Arginine depletion potentiates standard-of-care chemo-immunotherapy in preclinical models of high-risk neuroblastoma.
Kimberley M Hanssen, Jayne Murray, Ruby Pandher, Stephanie Alfred, Laura D Gamble, Jamie I Fletcher

J Exp Clin Cancer Res· August 2025

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Modeling High-Risk Pediatric Cancers in Zebrafish to Inform Precision Therapy.
Nadine Azzam, Jamie I Fletcher, Nicole Melong, Loretta M S Lau, Emmy M Dolman

Cancer Res Commun· July 2025

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The PLK4 inhibitor RP-1664 demonstrates potent single-agent efficacy in neuroblastoma models through a dual mechanism of sensitivity.
John Maris, Isabel Soria-Bretones, Matias Casás-Selves, Minu Samanta, David Groff, Jamie Fletcher

Res Sq· July 2025

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Improving the integration of care for trans adults: ICTA a mixed-methods study.
Richard Holti, Evelyn Callahan, Jamie Fletcher, Sam Hope, Naomi Moller

Health Soc Care Deliv Res· August 2024

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The transcriptional co-repressor Runx1t1 is essential for MYCN-driven neuroblastoma tumorigenesis.
Jayne E Murray, Emanuele Valli, Giorgio Milazzo, Chelsea Mayoh, Andrew J Gifford, Jamie I Fletcher

Nat Commun· July 2024

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miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma.
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Jamie Fletcher

Mol Ther· June 2024

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Generation of Orthotopic and Subcutaneous Patient-Derived Xenograft Models from Diverse Clinical Tissue Samples of Pediatric Extracranial Solid Tumors.
Kimberley M Hanssen, Jamie I Fletcher, Alvin Kamili

Methods Mol Biol· April 2024

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The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.
Christopher B Nelson, Samuel Rogers, Kaushik Roychoudhury, Yaw Sing Tan, Caroline J Atkinson, Jamie I Fletcher

Nat Commun· February 2024

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Dobbs v Jackson Women's Health Organization (2022): consequences one year on.
Emily Ottley, Karolina Szopa, Jamie Fletcher

Med Law Rev· August 2023

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High-Throughput Drug Screening of Primary Tumor Cells Identifies Therapeutic Strategies for Treating Children with High-Risk Cancer.
Chelsea Mayoh, Jie Mao, Jinhan Xie, Gabor Tax, Shu-Oi Chow, Jamie I Fletcher

Cancer Res· August 2023

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Inhibition of mitochondrial translocase SLC25A5 and histone deacetylation is an effective combination therapy in neuroblastoma.
Janith A Seneviratne, Daniel R Carter, Rituparna Mittra, Andrew Gifford, Patrick Y Kim, Jamie I Fletcher

Int J Cancer· April 2023

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Generation and multi-dimensional profiling of a childhood cancer cell line atlas defines new therapeutic opportunities.
Claire Xin Sun, Paul Daniel, Gabrielle Bradshaw, Hui Shi, Melissa Loi, Jamie I Fletcher

Cancer Cell· April 2023

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Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma.
Jordan F Hastings, Sharissa L Latham, Alvin Kamili, Madeleine S Wheatley, Jeremy Z R Han, Jamie I Fletcher

Sci Adv· March 2023

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GSH facilitates the binding and inhibitory activity of novel multidrug resistance protein 1 (MRP1) modulators.
Kimberley M Hanssen, Madeleine S Wheatley, Denise M T Yu, Gwenaëlle Conseil, Murray D Norris, Jamie I Fletcher

FEBS J· July 2022

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Quantification of vincristine and tariquidar by liquid chromatography-tandem mass spectrometry in mouse whole blood using volumetric absorptive microsampling for pharmacokinetic applications.
Sebastian P A Rosser, Caroline Atkinson, Christa E Nath, Jamie I Fletcher

J Sep Sci· July 2022

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In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer.
Loretta M S Lau, Chelsea Mayoh, Jinhan Xie, Paulette Barahona, Karen L MacKenzie, Jamie I Fletcher

EMBO Mol Med· April 2022

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miR-99b-5p, miR-380-3p, and miR-485-3p are novel chemosensitizing miRNAs in high-risk neuroblastoma.
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Jamie Fletcher

Mol Ther· March 2022

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Whole-genome sequencing facilitates patient-specific quantitative PCR-based minimal residual disease monitoring in acute lymphoblastic leukaemia, neuroblastoma and Ewing sarcoma.
Vinod Vijay Subhash, Libby Huang, Alvin Kamili, Marie Wong, Dan Chen, Jamie I Fletcher

Br J Cancer· February 2022

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Methodological advances in the discovery of novel neuroblastoma therapeutics.
Miguel F Segura, Aroa Soriano, Josep Roma, Olga Piskareva, Carlos Jiménez, Jamie I Fletcher

Expert Opin Drug Discov· February 2022

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Targeting multidrug resistance-associated protein 1 (MRP1)-expressing cancers: Beyond pharmacological inhibition.
Kimberley M Hanssen, Michelle Haber, Jamie I Fletcher

Drug Resist Updat· December 2021

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A Primer for Assessing the Pathology in Mouse Models of Neuroblastoma.
Andrew J Gifford, Jayne Murray, Jamie I Fletcher, Glenn M Marshall, Murray D Norris

Curr Protoc· November 2021

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