Publications by authors named "Jason Burke"

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Structural and functional analysis of cancer-associated missense variants in the retinoblastoma protein pocket domain.
Anthony Castro, Alfredo Ruiz Rivera, Chad C Moorman, Emma R Wolf-Saxon, Hailey N Mims, Jason R Burke

J Biol Chem· March 2025

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Regulatory ligand binding in plant chalcone isomerase-like (CHIL) proteins.
Emma R Wolf-Saxon, Chad C Moorman, Anthony Castro, Alfredo Ruiz-Rivera, Jeremy P Mallari, Jason R Burke

J Biol Chem· June 2023

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Discovery of 6-[(3,4)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.
Barbara Czako, Yuting Sun, Timothy McAfoos, Jason B Cross, Paul G Leonard, Jason P Burke

J Med Chem· October 2021

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Matthew M Hamilton, Faika Mseeh, Timothy J McAfoos, Paul G Leonard, Naphtali J Reyna, Jason P Burke

J Med Chem· August 2021

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Entrustable Professional Activity-Based Summative Performance Assessment in the Surgery Clerkship.
Amy L Holmstrom, Matthew C Chia, Celia L O'Brien, David D Odell, Jason Burke

J Surg Educ· June 2021

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Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib.
Yuting Sun, Brooke A Meyers, Barbara Czako, Paul Leonard, Faika Mseeh, Jason P Burke

Cancer Res· November 2020

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Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
Michael J Soth, Kang Le, Maria Emilia Di Francesco, Matthew M Hamilton, Gang Liu, Jason P Burke

J Med Chem· November 2020

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Discovery of IACS-9439, a Potent, Exquisitely Selective, and Orally Bioavailable Inhibitor of CSF1R.
Barbara Czako, Joseph R Marszalek, Jason P Burke, Pijus Mandal, Paul G Leonard

J Med Chem· September 2020

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"Tandem" Nanomedicine Approach against Osteoclastogenesis: Polysulfide Micelles Synergically Scavenge ROS and Release Rapamycin.
Farah El Mohtadi, Richard d'Arcy, Jason Burke, Julio M Rios De La Rosa, Arianna Gennari

Biomacromolecules· February 2020

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One tick closer to a nuclear clock.
Jason T Burke

Nature· September 2019

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MPIC: Molecular Prognostic Indicators in Cirrhosis Database for Clinical Context-Specific Prognostic Biomarker Validation.
Shun H Yip, Naoto Fujiwara, Jason Burke, Anand Shetler, Celina Peralta

Front Genet· September 2019

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Strigolactone perception and deactivation by a hydrolase receptor DWARF14.
Yoshiya Seto, Rei Yasui, Hiromu Kameoka, Muluneh Tamiru, Mengmeng Cao, Jason Burke

Nat Commun· January 2019

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Publisher Correction: Evolution of chalcone isomerase from a noncatalytic ancestor.
Miriam Kaltenbach, Jason R Burke, Mirco Dindo, Anna Pabis, Fabian S Munsberg

Nat Chem Biol· October 2018

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Evolution of chalcone isomerase from a noncatalytic ancestor.
Miriam Kaltenbach, Jason R Burke, Mirco Dindo, Anna Pabis, Fabian S Munsberg

Nat Chem Biol· June 2018

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The Effect of Branching (Star Architecture) on Poly(d,l-lactide) (PDLLA) Degradation and Drug Delivery.
Jason Burke, Roberto Donno, Richard d'Arcy, Sarah Cartmell, Nicola Tirelli

Biomacromolecules· March 2017

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Branched polyesters: Preparative strategies and applications.
Richard d'Arcy, Jason Burke, Nicola Tirelli

Adv Drug Deliv Rev· December 2016

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High π-Facial and exo-Selectivity for the Intramolecular Diels-Alder Cycloaddition of Dodeca-3,9,11-trien-5-one Precursors to 2-epi-Symbioimine and Related Compounds.
Ming Xiang, Yiwei Wu, Jason P Burke, Jason J Chruma

J Org Chem· September 2016

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A Strategy for Direct Chemical Activation of the Retinoblastoma Protein.
Cameron R Pye, Walter M Bray, Elise R Brown, Jason R Burke, R Scott Lokey

ACS Chem Biol· May 2016

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Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.
Jason P Burke, Zhiguo Bian, Subrata Shaw, Bin Zhao, Craig M Goodwin

J Med Chem· May 2015

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Multiple mechanisms for E2F binding inhibition by phosphorylation of the retinoblastoma protein C-terminal domain.
Jason R Burke, Tyler J Liban, Tamara Restrepo, Hsiau-Wei Lee, Seth M Rubin

J Mol Biol· January 2014

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Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.
Anders Friberg, Dominico Vigil, Bin Zhao, R Nathan Daniels, Jason P Burke

J Med Chem· January 2013

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Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.
Qi Sun, Jason P Burke, Jason Phan, Michael C Burns, Edward T Olejniczak

Angew Chem Int Ed Engl· June 2012

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Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control.
Jason R Burke, Greg L Hura, Seth M Rubin

Genes Dev· June 2012

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Crystal structure of the unliganded retinoblastoma protein pocket domain.
Eva Rose M Balog, Jason R Burke, Greg L Hura, Seth M Rubin

Proteins· June 2011

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Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.
Eugen F Mesaros, Jason P Burke, Jonathan D Parrish, Benjamin J Dugan, Andrew V Anzalone

Bioorg Med Chem Lett· January 2011

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