Publications by authors named "Jason Ear"

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Daple-FLT3 (CCDC88C-FLT3) gene fusion requires the coiled-coil domain for maximal activation and pericentrosomal localization.
Darren Kao, Michael Acquazzino, Arnel Ibarra, Elena Valenzuela, Haley Mai, Jason Ear

bioRxiv· September 2025

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A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.
Courtney Tindle, Ayden G Fonseca, Sahar Taheri, Gajanan D Katkar, Jasper Lee, Jason Ear

Cell Rep Med· October 2024

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Complement receptor 3 is required for maximum in vitro trogocytic killing of the parasite Trichomonas vaginalis by human neutrophil-like cells.
Emma N Trujillo, Barbara A Flores, Isabel V Romero, Jose A Moran, Aljona Leka, Jason Ear

Parasite Immunol· February 2024

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A Living Organoid Biobank of Crohn's Disease Patients Reveals Molecular Subtypes for Personalized Therapeutics.
Courtney Tindle, Gajanan D Katkar, Ayden G Fonseca, Sahar Taheri, Jasper Lee, Jason Ear

bioRxiv· March 2023

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Regulation of DNA damage response by trimeric G-proteins.
Amer Ali Abd El-Hafeez, Nina Sun, Anirban Chakraborty, Jason Ear, Suchismita Roy

iScience· February 2023

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A long isoform of GIV/Girdin contains a PDZ-binding module that regulates localization and G-protein binding.
Jason Ear, Amer Ali Abd El-Hafeez, Suchismita Roy, Tony Ngo, Navin Rajapakse

J Biol Chem· September 2021

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E-cigarettes compromise the gut barrier and trigger inflammation.
Aditi Sharma, Jasper Lee, Ayden G Fonseca, Alex Moshensky, Taha Kothari, Jason Ear

iScience· February 2021

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Correction: DAPLE protein inhibits nucleotide exchange on Gαs and Gαq via the same motif that activates Gα.
Arthur Marivin, Marcin Maziarz, Jingyi Zhao, Vincent DiGiacomo, Isabel Olmos Calvo, Jason Ear

J Biol Chem· June 2020

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DAPLE protein inhibits nucleotide exchange on Gα and Gα via the same motif that activates Gαi.
Arthur Marivin, Marcin Maziarz, Jingyi Zhao, Vincent DiGiacomo, Isabel Olmos Calvo, Jason Ear

J Biol Chem· February 2020

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Tyrosine-Based Signals Regulate the Assembly of Daple⋅PARD3 Complex at Cell-Cell Junctions.
Jason Ear, Anokhi Saklecha, Navin Rajapakse, Julie Choi, Majid Ghassemian

iScience· February 2020

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Two Isoforms of the Guanine Nucleotide Exchange Factor, Daple/CCDC88C Cooperate as Tumor Suppressors.
Jason Ear, Ying Dunkel, Yash Mittal, Blaze B C Lim, Lawrence Liu

Sci Rep· August 2019

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Prognostic Relevance of CCDC88C (Daple) Transcripts in the Peripheral Blood of Patients with Cutaneous Melanoma.
Ying Dunkel, Anna L Reid, Jason Ear, Nicolas Aznar, Michael Millward, Robert Pearce

Sci Rep· December 2018

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Convergence of Wnt, growth factor, and heterotrimeric G protein signals on the guanine nucleotide exchange factor Daple.
Nicolas Aznar, Jason Ear, Ying Dunkel, Nina Sun, Kendall Satterfield

Sci Signal· February 2018

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A Daple-Akt feed-forward loop enhances noncanonical Wnt signals by compartmentalizing β-catenin.
Nicolas Aznar, Nina Sun, Ying Dunkel, Jason Ear, Matthew D Buschman

Mol Biol Cell· December 2017

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RNA methylation regulates hematopoietic stem and progenitor cell development.
Jason Ear, Shuo Lin

J Genet Genomics· October 2017

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Biochemical, Biophysical and Cellular Techniques to Study the Guanine Nucleotide Exchange Factor, GIV/Girdin.
Pradipta Ghosh, Nicolas Aznar, Lee Swanson, I-Chung Lo, Inmaculada Lopez-Sanchez, Jason Ear

Curr Protoc Chem Biol· December 2016

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GIV/Girdin activates Gαi and inhibits Gαs via the same motif.
Vijay Gupta, Deepali Bhandari, Anthony Leyme, Nicolas Aznar, Krishna K Midde, Jason Ear

Proc Natl Acad Sci U S A· September 2016

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A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure.
Jason Ear, Jessica Hsueh, Melinda Nguyen, QingHua Zhang, Victoria Sung

J Genet Genomics· May 2016

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RAP-011 improves erythropoiesis in zebrafish model of Diamond-Blackfan anemia through antagonizing lefty1.
Jason Ear, Haigen Huang, Tianna Wilson, Zahra Tehrani, Anne Lindgren

Blood· August 2015

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Structural basis for activation of trimeric Gi proteins by multiple growth factor receptors via GIV/Girdin.
Changsheng Lin, Jason Ear, Krishna Midde, Inmaculada Lopez-Sanchez, Nicolas Aznar

Mol Biol Cell· November 2014

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Zebrafish high-throughput screening to study the impact of dissolvable metal oxide nanoparticles on the hatching enzyme, ZHE1.
Sijie Lin, Yan Zhao, Zhaoxia Ji, Jason Ear, Chong Hyun Chang

Small· May 2013

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Tandem SAM domain structure of human Caskin1: a presynaptic, self-assembling scaffold for CASK.
Ryan L Stafford, Elizabeth Hinde, Mary Jane Knight, Mario A Pennella, Jason Ear

Structure· December 2011

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The molecular basis of the Caskin1 and Mint1 interaction with CASK.
Ryan L Stafford, Jason Ear, Mary Jane Knight, James U Bowie

J Mol Biol· September 2011

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Tyrosine phosphorylation of the Gα-interacting protein GIV promotes activation of phosphoinositide 3-kinase during cell migration.
Changsheng Lin, Jason Ear, Yelena Pavlova, Yash Mittal, Irina Kufareva

Sci Signal· September 2011

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A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals.
Mikel Garcia-Marcos, Jason Ear, Marilyn G Farquhar, Pradipta Ghosh

Mol Biol Cell· March 2011

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