Publications by authors named "Jason Rech"

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FDA-approved drug repurposing in zebrafish identifies thyroid hormone and other compounds as potential antithrombotics.
Murat Yaman, Hongyu Su, Jacqueline K Lee, Allison C Ferguson, Katherine M Sowell, Jason C Rech

bioRxiv· October 2025

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CRISPR RiPCA for Investigating eIF4E-mGpppX Capped mRNA Interactions.
Gabriela Vega-Hernández, Jesse Duque, Brandon J C Klein, Dalia M Soueid, Jason C Rech

ACS Chem Biol· August 2025

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A Novel, Long-Acting, Small Molecule PKM2 Activator and Its Potential Broad Application Against Photoreceptor Degeneration.
Warren W Pan, Katherine M Weh, Sraboni Chaudhury, Roshini Fernando, Heather Hager, Jason C Rech

Transl Vis Sci Technol· July 2025

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CRISPR RiPCA for Investigating eIF4E-mGpppX Capped mRNA Interactions.
Gabriela Vega-Hernández, Jesse Duque, Brandon J C Klein, Dalia M Soueid, Jason C Rech

bioRxiv· June 2025

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Small-Molecule FICD Inhibitors Suppress Endogenous and Pathologic FICD-Mediated Protein AMPylation.
Bhaskar K Chatterjee, Maroof Alam, Arghya Chakravorty, Shannon M Lacy, William Giblin, Jason Rech

ACS Chem Biol· April 2025

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Structure-Activity Relationships and Molecular Pharmacology of Positive Allosteric Modulators of the Mu-Opioid Receptor.
Mengchu Li, Xinmin Gan, Kun Liu, Walajapet G Rajeswaran, M Alex Stanczyk, Jason C Rech

ACS Chem Neurosci· January 2025

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Studies of Structure-Activity Relationship of 2-(Pyrrolidin-1ylmethyl)-1-pyrrole-Based ST2 Inhibitors and Their Inhibition of Mast Cells Activation.
Xinrui Yuan, Jason C Rech, Andhavaram Ramaraju, Amol D Patil, Krishani Rajanayake

ACS Med Chem Lett· November 2024

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Characterization of tritiated JNJ-GluN2B-5 (3-[H] 1-(azetidin-1-yl)-2-(6-(4-fluoro-3-methyl-phenyl)pyrrolo[3,2-b]pyridin-1-yl)ethanone), a high affinity GluN2B radioligand with selectivity over sigma receptors.
Jeffrey Schoellerman, Brian Lord, Anindya Bhattacharya, Brice Stenne, Jessica L Wall, Jason Rech

J Neurochem· September 2024

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Can Machine Learning Overcome the 95% Failure Rate and Reality that Only 30% of Approved Cancer Drugs Meaningfully Extend Patient Survival?
Duxin Sun, Christian Macedonia, Zhigang Chen, Sriram Chandrasekaran, Kayvan Najarian, Jason C Rech

J Med Chem· September 2024

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Small molecule FICD inhibitors suppress endogenous and pathologic FICD-mediated protein AMPylation.
Bhaskar K Chatterjee, Maroof Alam, Arghya Chakravorty, Shannon M Lacy, Jason Rech

bioRxiv· July 2024

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Molecular determinants of ASIC1 modulation by divalent cations.
Yi Liu, Jichun Ma, Renee L DesJarlais, Rebecca Hagan, Jason Rech

Sci Rep· January 2024

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Cellular rules underlying psychedelic control of prefrontal pyramidal neurons.
Tyler G Ekins, Isla Brooks, Sameer Kailasa, Chloe Rybicki-Kler, Izabela Jedrasiak-Cape, Jason Rech

bioRxiv· October 2023

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Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors.
Xinrui Yuan, Hua Jiang, Denggang Fu, Jason C Rech, Aaron Robida

ACS Pharmacol Transl Sci· September 2023

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Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis.
Thomas J Wubben, Sraboni Chaudhury, Brennan T Watch, Jeanne A Stuckey, Eric Weh, Jason C Rech

Pharmaceuticals (Basel)· May 2023

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Structure-Activity relationship of 1-(Furan-2ylmethyl)Pyrrolidine-Based Stimulation-2 (ST2) inhibitors for treating graft versus host disease.
Xinrui Yuan, Hua Jiang, Denggang Fu, Aaron Robida, Krishani Rajanayake, Jason C Rech

Bioorg Med Chem· October 2022

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A global review of beaver dam impacts: Stream conservation implications across biomes.
Bartosz P Grudzinski, Ken Fritz, Heather E Golden, Tammy A Newcomer-Johnson, Jason A Rech

Glob Ecol Conserv· September 2022

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Molecular mechanism and structural basis of small-molecule modulation of the gating of acid-sensing ion channel 1.
Yi Liu, Jichun Ma, Renee L DesJarlais, Rebecca Hagan, Jason Rech

Commun Biol· February 2021

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Glycine-based treatment ameliorates NAFLD by modulating fatty acid oxidation, glutathione synthesis, and the gut microbiome.
Oren Rom, Yuhao Liu, Zhipeng Liu, Ying Zhao, Jianfeng Wu, Jason C Rech

Sci Transl Med· December 2020

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1-Pyrrolo[3,2-]pyridine GluN2B-Selective Negative Allosteric Modulators.
Christa C Chrovian, Akinola Soyode-Johnson, Jessica L Wall, Jason C Rech, Jeff Schoellerman

ACS Med Chem Lett· March 2019

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From proteomics to discovery of first-in-class ST2 inhibitors active in vivo.
Abdulraouf M Ramadan, Etienne Daguindau, Jason C Rech, Krishnapriya Chinnaswamy, Jilu Zhang

JCI Insight· July 2018

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The discovery and preclinical characterization of 6-chloro-N-(2-(4,4-difluoropiperidin-1-yl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)ethyl)quinoline-5-carboxamide based P2X7 antagonists.
Jason C Rech, Anindya Bhattacharya, Bryan J Branstetter, Christopher J Love, Joseph E Leenaerts

Bioorg Med Chem Lett· October 2016

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Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.
Devin M Swanson, Brad M Savall, Kevin J Coe, Freddy Schoetens, Tatiana Koudriakova, Jason Rech

J Med Chem· September 2016

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The evolution of P2X7 antagonists with a focus on CNS indications.
Jason C Rech, Anindya Bhattacharya, Michael A Letavic, Brad M Savall

Bioorg Med Chem Lett· August 2016

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P2X7 receptor antagonism reduces the severity of spontaneous seizures in a chronic model of temporal lobe epilepsy.
Halima Amhaoul, Idrish Ali, Marco Mola, Annemie Van Eetveldt, Krystyna Szewczyk, Jason Rech

Neuropharmacology· June 2016

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Novel Phenyl-Substituted 5,6-Dihydro-[1,2,4]triazolo[4,3-a]pyrazine P2X7 Antagonists with Robust Target Engagement in Rat Brain.
Christa C Chrovian, Akinola Soyode-Johnson, Hong Ao, Genesis M Bacani, Nicholas I Carruthers, Jason C Rech

ACS Chem Neurosci· April 2016

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