Publications by authors named "Jason Xiang"

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A shortened interval between vaccinations with the trivalent inactivated influenza vaccine increases responsiveness in the aged.
Senthil Kannan, Andrew Kossenkov, Raj K Kurupati, Jason Zq Xiang, Susan A Doyle

Aging (Albany NY)· December 2015

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Discovery of HSD-621 as a Potential Agent for the Treatment of Type 2 Diabetes.
Zhao-Kui Wan, Eva Chenail, Huan-Qiu Li, Manus Ipek, Jason Xiang, Xiangping Li

ACS Med Chem Lett· January 2013

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Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.
Yonghan Hu, Li Xing, Jennifer R Thomason, Jason Xiang, Manus Ipek

Bioorg Med Chem Lett· November 2011

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Synthesis of potent and orally efficacious 11β-hydroxysteroid dehydrogenase type 1 inhibitor HSD-016.
Zhao-Kui Wan, Eva Chenail, Huan-Qiu Li, Christopher Kendall, Youchu Wang, Jason Xiang

J Org Chem· September 2011

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Comparative pharmacokinetics and metabolism studies in lean and diet- induced obese mice: an animal efficacy model for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitors.
Mengmeng Wang, Xianbin Tian, Louis Leung, Jianyao Wang, Nicole Houvig, Jason Xiang

Drug Metab Lett· January 2011

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Efficacious 11beta-hydroxysteroid dehydrogenase type I inhibitors in the diet-induced obesity mouse model.
Zhao-Kui Wan, Eva Chenail, Jason Xiang, Huan-Qiu Li, Manus Ipek, Xiangping Li

J Med Chem· September 2009

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Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties.
Steven J Kirincich, Jason Xiang, Neal Green, Steve Tam, Hui Y Yang

Bioorg Med Chem· July 2009

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Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: a class of potent aggrecanase-1 inhibitors.
Darrin W Hopper, Matthew D Vera, David How, Joshua Sabatini, Jason S Xiang

Bioorg Med Chem Lett· May 2009

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Piperazine sulfonamides as potent, selective, and orally available 11beta-hydroxysteroid dehydrogenase type 1 inhibitors with efficacy in the rat cortisone-induced hyperinsulinemia model.
Jason Xiang, Zhao-Kui Wan, Huan-Qiu Li, Manus Ipek, Eva Binnun, Xiangping Li

J Med Chem· July 2008

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beta-Keto sulfones as inhibitors of 11beta-hydroxysteroid dehydrogenase type I and the mechanism of action.
Jason Xiang, Manus Ipek, Vipin Suri, May Tam, Yuzhe Xing

Bioorg Med Chem· July 2007

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Synthesis and biological evaluation of biphenylsulfonamide carboxylate aggrecanase-1 inhibitors.
Jason S Xiang, Yonghan Hu, Thomas S Rush, Jennifer R Thomason, Manus Ipek

Bioorg Med Chem Lett· January 2006

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Potent, selective, and orally bioavailable matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Yonghan Hu, Jason S Xiang, Martin J DiGrandi, Xuemei Du, Manus Ipek

Bioorg Med Chem· December 2005

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Synthesis and SAR of highly selective MMP-13 inhibitors.
Jianchang Li, Thomas S Rush, Wei Li, Dianne DeVincentis, Xuemei Du, Jason S Xiang

Bioorg Med Chem Lett· November 2005

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Synthesis and biological evaluation of sulfonamidooxazoles and beta-keto sulfones: selective inhibitors of 11beta-hydroxysteroid dehydrogenase type I.
Jason Xiang, Manus Ipek, Vipin Suri, Walt Massefski, Ning Pan

Bioorg Med Chem Lett· June 2005

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Structure-activity studies of a series of dipyrazolo[3,4-b:3',4'-d]pyridin-3-ones binding to the immune regulatory protein B7.1.
Neal J Green, Jason Xiang, Jing Chen, Lihren Chen, Audrey M Davies

Bioorg Med Chem· July 2003

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