Publications by authors named "Steve Tam"

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Molecular Alterations in Cutaneous Squamous Cell Carcinoma in Immunocompetent and Immunosuppressed Hosts-A Systematic Review.
Denise Ann Tsang, Steve Y C Tam, Choon Chiat Oh

Cancers (Basel)· March 2023

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Chemoprevention of keratinocyte carcinoma and actinic keratosis in solid-organ transplant recipients: Systematic review and meta-analyses.
Louis Y Tee, Rehena Sultana, Steve Y C Tam, Choon Chiat Oh

J Am Acad Dermatol· February 2021

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Discovery of potent and selective matrix metalloprotease 12 inhibitors for the potential treatment of chronic obstructive pulmonary disease (COPD).
Yuchuan Wu, Jianchang Li, Junjun Wu, Paul Morgan, Xin Xu, Steve Tam

Bioorg Med Chem Lett· January 2012

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Continued exploration of biphenylsulfonamide scaffold as a platform for aggrecanase-1 inhibition.
Yonghan Hu, Li Xing, Jennifer R Thomason, Jason Xiang, Manus Ipek, Steve Tam

Bioorg Med Chem Lett· November 2011

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Selective functional inhibition of JAK-3 is sufficient for efficacy in collagen-induced arthritis in mice.
Tsung H Lin, Martin Hegen, Elizabeth Quadros, Cheryl L Nickerson-Nutter, Kenneth C Appell, Steve Tam

Arthritis Rheum· August 2010

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Discovery of 2-[1-(4-chlorophenyl)cyclopropyl]-3-hydroxy-8-(trifluoromethyl)quinoline-4-carboxylic acid (PSI-421), a P-selectin inhibitor with improved pharmacokinetic properties and oral efficacy in models of vascular injury.
Adrian Huang, Alessandro Moretto, Kristin Janz, Michael Lowe, Patricia W Bedard, Steve Tam

J Med Chem· August 2010

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Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
Somnath Mukhopadhyay, Joseph Sypek, Roger Tavendale, Ulrike Gartner, John Winter, Steve Tam

J Allergy Clin Immunol· July 2010

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Identification of an orally efficacious matrix metalloprotease 12 inhibitor for potential treatment of asthma.
Wei Li, Jianchang Li, Yuchuan Wu, Fabio Rancati, Stefania Vallese, Steve Tam

J Med Chem· September 2009

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3,4-Disubstituted benzofuran P1' MMP-13 inhibitors: optimization of selectivity and reduction of protein binding.
Wei Li, Yonghan Hu, Jianchang Li, Jennifer R Thomason, Dianne DeVincentis, Steve Tam

Bioorg Med Chem Lett· August 2009

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Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Junjun Wu, Neal Green, Rajeev Hotchandani, Yonghan Hu, Jeffrey Condon, Steve Y Tam

Bioorg Med Chem Lett· July 2009

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Benzhydrylquinazolinediones: novel cytosolic phospholipase A2alpha inhibitors with improved physicochemical properties.
Steven J Kirincich, Jason Xiang, Neal Green, Steve Tam, Hui Y Yang

Bioorg Med Chem· July 2009

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A selective matrix metalloprotease 12 inhibitor for potential treatment of chronic obstructive pulmonary disease (COPD): discovery of (S)-2-(8-(methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408).
Wei Li, Jianchang Li, Yuchuan Wu, Junjun Wu, Rajeev Hotchandani, Steve Tam

J Med Chem· April 2009

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Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.
Lihren Chen, Weiheng Wang, Katherine L Lee, Marina W H Shen, Elizabeth A Murphy, Steve Tam

J Med Chem· February 2009

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Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24.
Zhao-Kui Wan, Jinbo Lee, Rajeev Hotchandani, Alessandro Moretto, Eva Binnun, May Tam, Steve Y Tam

ChemMedChem· October 2008

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Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.
John C McKew, Katherine L Lee, Marina W H Shen, Paresh Thakker, Megan A Foley, Steve Tam

J Med Chem· June 2008

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Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy.
Katherine L Lee, Mark L Behnke, Megan A Foley, Lihren Chen, Weiheng Wang, Steve Tam

Bioorg Med Chem· February 2008

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Pharmacologic inhibition of tpl2 blocks inflammatory responses in primary human monocytes, synoviocytes, and blood.
J Perry Hall, Yahya Kurdi, Sang Hsu, John Cuozzo, Julie Liu, Steve Tam

J Biol Chem· November 2007

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Identification of a novel class of selective Tpl2 kinase inhibitors: 4-Alkylamino-[1,7]naphthyridine-3-carbonitriles.
Neelu Kaila, Neal Green, Huan-Qiu Li, Yonghan Hu, Kristin Janz, Steve Tam

Bioorg Med Chem· October 2007

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Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.
Douglas P Wilson, Zhao-Kui Wan, Wei-Xin Xu, Steven J Kirincich, Bruce C Follows, May Tam, Steve Y Tam

J Med Chem· September 2007

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Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles.
Neal Green, Yonghan Hu, Kristin Janz, Huan-Qiu Li, Neelu Kaila, Steve Y Tam

J Med Chem· September 2007

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Probing acid replacements of thiophene PTP1B inhibitors.
Zhao-Kui Wan, Bruce Follows, Steve Kirincich, Douglas Wilson, Eva Binnun, May Tam, Steve Tam

Bioorg Med Chem Lett· May 2007

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Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha.
Katherine L Lee, Megan A Foley, Lihren Chen, Mark L Behnke, Frank E Lovering, Steve Tam

J Med Chem· March 2007

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Synthesis and biological evaluation of quinoline salicylic acids as P-selectin antagonists.
Neelu Kaila, Kristin Janz, Silvano DeBernardo, Patricia W Bedard, Raymond T Camphausen, Steve Tam

J Med Chem· January 2007

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2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic acid (PSI-697): identification of a clinical candidate from the quinoline salicylic acid series of P-selectin antagonists.
Neelu Kaila, Kristin Janz, Adrian Huang, Alessandro Moretto, Silvano DeBernardo, Steve Tam

J Med Chem· January 2007

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Inhibition of Tpl2 kinase and TNFalpha production with quinoline-3-carbonitriles for the treatment of rheumatoid arthritis.
Yonghan Hu, Neal Green, Lori K Gavrin, Kristin Janz, Neelu Kaila, Steve Tam

Bioorg Med Chem Lett· December 2006

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