Publications by authors named "Jay Groppe"

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Matrix metalloproteinase-9 deficiency confers resilience in fibrodysplasia ossificans progressiva in a man and mice.
Vitali Lounev, Jay C Groppe, Niambi Brewer, Kelly L Wentworth, Victoria Smith

J Bone Miner Res· May 2024

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Polypeptide Substrate Accessibility Hypothesis: Gain-of-Function R206H Mutation Allosterically Affects Activin Receptor-like Protein Kinase Activity.
Jay C Groppe, Guorong Lu, Mary R Tandang-Silvas, Anupama Pathi, Shruti Konda

Biomolecules· July 2023

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Functional Testing of Bone Morphogenetic Protein (BMP) Pathway Variants Identified on Whole-Exome Sequencing in a Patient with Delayed-Onset Fibrodysplasia Ossificans Progressiva (FOP) Using ACVR1 -Specific Human Cellular and Zebrafish Models.
Kelly L Wentworth, Robert L Lalonde, Jay C Groppe, Niambi Brewer, Tania Moody

J Bone Miner Res· November 2022

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An ACVR1 pathogenic variant in two families with mild fibrodysplasia ossificans progressiva.
Frederick S Kaplan, Jay C Groppe, Meiqi Xu, O Will Towler, Eduardo Grunvald

Am J Med Genet A· March 2022

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Induced degradation of protein kinases by bifunctional small molecules: a next-generation strategy.
Jay C Groppe

Expert Opin Drug Discov· December 2019

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Hypoxia-selective allosteric destabilization of activin receptor-like kinases: A potential therapeutic avenue for prophylaxis of heterotopic ossification.
Guorong Lu, Mary R Tandang-Silvas, Alyssa C Dawson, Trenton J Dawson, Jay C Groppe

Bone· July 2018

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Cellular Hypoxia Promotes Heterotopic Ossification by Amplifying BMP Signaling.
Haitao Wang, Carter Lindborg, Vitali Lounev, Jung-Hoon Kim, Ruth McCarrick-Walmsley, Jay C Groppe

J Bone Miner Res· September 2016

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Multi-system involvement in a severe variant of fibrodysplasia ossificans progressiva (ACVR1 c.772G>A; R258G): A report of two patients.
Frederick S Kaplan, Joyce A Kobori, Carmen Orellana, Inmaculada Calvo, Monica Rosello, Jay C Groppe

Am J Med Genet A· October 2015

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Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.
Malcolm Whitman, Vicki Rosen, Ali H Brivanlou, Jay C Groppe, Walter Sebald

Nat Med· July 2013

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Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
Julia Zimmer, Sandra C Doelken, Denise Horn, Jay C Groppe, Eileen M Shore

PLoS One· November 2012

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Inactivation of a novel FGF23 regulator, FAM20C, leads to hypophosphatemic rickets in mice.
Xiaofang Wang, Suzhen Wang, Changcheng Li, Tian Gao, Ying Liu, Jay Groppe

PLoS Genet· September 2012

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Nucleotide polymorphisms in the canine Noggin gene and their distribution among dog (Canis lupus familiaris) breeds.
Yuji Ishii, Tatsuya Takizawa, Hiroshi Iwasaki, Yukihiro Fujita, Masaru Murakami, Jay C Groppe

Biochem Genet· February 2012

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In vitro analyses of the dysregulated R206H ALK2 kinase-FKBP12 interaction associated with heterotopic ossification in FOP.
Jay C Groppe, Jingfeng Wu, Eileen M Shore, Frederick S Kaplan

Cells Tissues Organs· December 2011

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The TβR-I pre-helix extension is structurally ordered in the unbound form and its flanking prolines are essential for binding.
Jorge E Zuniga, Udayar Ilangovan, Pardeep Mahlawat, Cynthia S Hinck, Tao Huang, Jay C Groppe

J Mol Biol· September 2011

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Identification of a core domain within the proregion of bone morphogenetic proteins that interacts with the dimeric, mature domain.
Silke Kuhfahl, Anja Hauburger, Tino Thieme, Jay Groppe, Christian Ihling

Biochem Biophys Res Commun· May 2011

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Intricacies of BMP receptor assembly.
Joachim Nickel, Walter Sebald, Jay C Groppe, Thomas D Mueller

Cytokine Growth Factor Rev· March 2010

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Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN.
Petra Seemann, Anja Brehm, Jana König, Carsten Reissner, Sigmar Stricker, Jay C Groppe

PLoS Genet· November 2009

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Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9.
Ying Wang, Jay C Groppe, Jingfeng Wu, Takuya Ogawa, Gabriele Mues

Hum Mol Genet· August 2009

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Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1.
Frederick S Kaplan, Meiqi Xu, Petra Seemann, J Michael Connor, David L Glaser, Jay Groppe

Hum Mutat· March 2009

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Skeletal metamorphosis in fibrodysplasia ossificans progressiva (FOP).
Frederick S Kaplan, Qi Shen, Vitali Lounev, Petra Seemann, Jay Groppe

J Bone Miner Metab· December 2008

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Fibrodysplasia ossificans progressiva.
Frederick S Kaplan, Martine Le Merrer, David L Glaser, Robert J Pignolo, Robert E Goldsby, Jay Groppe

Best Pract Res Clin Rheumatol· March 2008

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Cooperative assembly of TGF-beta superfamily signaling complexes is mediated by two disparate mechanisms and distinct modes of receptor binding.
Jay Groppe, Cynthia S Hinck, Payman Samavarchi-Tehrani, Chloe Zubieta, Jonathan P Schuermann

Mol Cell· February 2008

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When one skeleton is enough: approaches and strategies for the treatment of fibrodysplasia ossificans progressiva (FOP).
Frederick S Kaplan, Jay Groppe, Eileen M Shore

Drug Discov Today Ther Strateg· January 2008

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Morphogen receptor genes and metamorphogenes: skeleton keys to metamorphosis.
Frederick S Kaplan, Jay Groppe, Robert J Pignolo, Eileen M Shore

Ann N Y Acad Sci· November 2007

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Functional modeling of the ACVR1 (R206H) mutation in FOP.
Jay C Groppe, Eileen M Shore, Frederick S Kaplan

Clin Orthop Relat Res· September 2007

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