Publications by authors named "Malcolm Whitman"

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GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling.
Changqian Zhou, Miao Zhang, Jason Murray, Joao Paulo, Steve Gygi, Malcolm Whitman

Science· October 2025

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Extension of lifespan by epicatechin, halofuginone and mitoglitazone in male but not female genetically heterogeneous mice.
Randy Strong, James F Nelson, Molly A Bogue, Jerry R Colca, Martin Denzel, Malcolm Whitman

Geroscience· September 2025

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Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance.
Mark A Tye, N Connor Payne, Catrine Johansson, Kritika Singh, Sofia A Santos, Malcolm Whitman

Nat Commun· August 2022

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Loss of Vlk in Prx1 Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb.
David E Maridas, Laura Gamer, Emily R Moore, Annemiek M Doedens, Yunqing Yu, Malcolm Whitman

J Bone Miner Res· April 2022

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The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation.
Leila Revollo, Glenn Merrill-Skoloff, Karen De Ceunynck, James R Dilks, Shihui Guo, Malcolm Whitman

Blood· January 2022

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Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Yeonjin Kim, Mark S Sundrud, Changqian Zhou, Maja Edenius, Davide Zocco, Malcolm Whitman

Proc Natl Acad Sci U S A· April 2020

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Halofuginone treatment reduces interleukin-17A and ameliorates features of chronic lung allograft dysfunction in a mouse orthotopic lung transplant model.
Hisashi Oishi, Tereza Martinu, Masaaki Sato, Yasushi Matsuda, Shin Hirayama, Malcolm R Whitman

J Heart Lung Transplant· April 2016

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Evidence for cadherin-11 cleavage in the synovium and partial characterization of its mechanism.
Erika H Noss, Gerald F M Watts, Davide Zocco, Tracy L Keller, Malcolm Whitman

Arthritis Res Ther· May 2015

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The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.
Jonathan D Herman, Lauren R Pepper, Joseph F Cortese, Guillermina Estiu, Kevin Galinsky, Malcolm Whitman

Sci Transl Med· May 2015

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Premature Termination Codons Are Recognized in the Nucleus in A Reading-Frame Dependent Manner.
Min Shi, Heng Zhang, Lantian Wang, Changlan Zhu, Ke Sheng, Malcolm Whitman

Cell Discov· May 2015

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A secreted tyrosine kinase acts in the extracellular environment.
Mattia R Bordoli, Jina Yum, Susanne B Breitkopf, Jonathan N Thon, Joseph E Italiano, Malcolm Whitman

Cell· August 2014

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A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.
Hugh Young Rienhoff, Chang-Yeol Yeo, Rachel Morissette, Irina Khrebtukova, Jonathan Melnick, Malcolm Whitman

Am J Med Genet A· August 2013

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Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3.
Malcolm Whitman, Vicki Rosen, Ali H Brivanlou, Jay C Groppe, Walter Sebald

Nat Med· July 2013

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Small ubiquitin-like modifier (SUMO) modification mediates function of the inhibitory domains of developmental regulators FOXC1 and FOXC2.
Theodora E Danciu, Sergey Chupreta, Osvaldo Cruz, Jennifer E Fox, Malcolm Whitman

J Biol Chem· May 2012

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Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Tracy L Keller, Davide Zocco, Mark S Sundrud, Margaret Hendrick, Maja Edenius, Malcolm Whitman

Nat Chem Biol· February 2012

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Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.
Yana G Kamberov, Jihoon Kim, Ralph Mazitschek, Winston P Kuo, Malcolm Whitman

BMC Res Notes· October 2011

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The role and regulation of GDF11 in Smad2 activation during tailbud formation in the Xenopus embryo.
Diana M Ho, Chang-Yeol Yeo, Malcolm Whitman

Mech Dev· June 2011

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Oxidative stress drives disulfide bond formation between basic helix-loop-helix transcription factors.
Theodora E Danciu, Malcolm Whitman

J Cell Biochem· February 2010

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Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response.
Mark S Sundrud, Sergei B Koralov, Markus Feuerer, Dinis Pedro Calado, Aimee Elhed Kozhaya, Malcolm Whitman

Science· June 2009

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TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates.
Yasuko Onuma, Akira Watanabe, Hiroyuki Aburatani, Makoto Asashima, Malcolm Whitman

Zoolog Sci· July 2008

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Identification of a novel pool of extracellular pro-myostatin in skeletal muscle.
Sarah B Anderson, Alfred L Goldberg, Malcolm Whitman

J Biol Chem· March 2008

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TGF-beta signaling is required for multiple processes during Xenopus tail regeneration.
Diana M Ho, Malcolm Whitman

Dev Biol· March 2008

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Inhibitor-resistant type I receptors reveal specific requirements for TGF-beta signaling in vivo.
Diana M Ho, Joanne Chan, Peter Bayliss, Malcolm Whitman

Dev Biol· July 2006

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A Serpin family gene, protease nexin-1 has an activity distinct from protease inhibition in early Xenopus embryos.
Yasuko Onuma, Makoto Asashima, Malcolm Whitman

Mech Dev· June 2006

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XCR2, one of three Xenopus EGF-CFC genes, has a distinct role in the regulation of left-right patterning.
Yasuko Onuma, Chang-Yeol Yeo, Malcolm Whitman

Development· January 2006

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