Publications by authors named "Jay Janz"

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Snapshots of actin and tubulin folding inside the TRiC chaperonin.
John J Kelly, Dale Tranter, Els Pardon, Gamma Chi, Holger Kramer, Jay M Janz

Nat Struct Mol Biol· May 2022

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PF-07059013: A non-covalent hemoglobin modulator favorably impacts disease state in a mouse model of sickle cell disease.
Kelly M Knee, Reema Jasuja, Amey Barakat, Dharani Rao, Zane Wenzel, Jay M Janz

Am J Hematol· August 2021

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
Ariamala Gopalsamy, Ann E Aulabaugh, Amey Barakat, Kevin C Beaumont, Shawn Cabral, Jay M Janz

J Med Chem· January 2021

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Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.
Nicholas G Fox, Alain Martelli, Joseph F Nabhan, Jay Janz, Oktawia Borkowska

Biochimie· September 2018

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Decay of an active GPCR: Conformational dynamics govern agonist rebinding and persistence of an active, yet empty, receptor state.
Christopher T Schafer, Jonathan F Fay, Jay M Janz, David L Farrens

Proc Natl Acad Sci U S A· October 2016

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Inter-domain communication of human cystathionine β-synthase: structural basis of S-adenosyl-L-methionine activation.
Thomas J McCorvie, Jolanta Kopec, Suk-Joon Hyung, Fiona Fitzpatrick, Xidong Feng, Jay M Janz

J Biol Chem· December 2014

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Development and characterization of pepducins as Gs-biased allosteric agonists.
Richard Carr, Yang Du, Julie Quoyer, Reynold A Panettieri, Jay M Janz

J Biol Chem· December 2014

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Pepducin targeting the C-X-C chemokine receptor type 4 acts as a biased agonist favoring activation of the inhibitory G protein.
Julie Quoyer, Jay M Janz, Jiansong Luo, Yong Ren, Sylvain Armando

Proc Natl Acad Sci U S A· December 2013

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Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4.
Jay M Janz, Yong Ren, Richard Looby, Manija A Kazmi, Pallavi Sachdev

J Am Chem Soc· October 2011

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G protein-coupled receptor modulation with pepducins: moving closer to the clinic.
Patricia Dimond, Kenneth Carlson, Michel Bouvier, Craig Gerard, Lei Xu, Jay M Janz

Ann N Y Acad Sci· May 2011

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Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells.
Boris Tchernychev, Yong Ren, Pallavi Sachdev, Jay M Janz, Lynn Haggis

Proc Natl Acad Sci U S A· December 2010

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A novel interaction between atrophin-interacting protein 4 and beta-p21-activated kinase-interactive exchange factor is mediated by an SH3 domain.
Jay M Janz, Thomas P Sakmar, K Christopher Min

J Biol Chem· September 2007

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Crystal structure of the SH3 domain of betaPIX in complex with a high affinity peptide from PAK2.
André Hoelz, Jay M Janz, Steven D Lawrie, Brian Corwin, Adrian Lee

J Mol Biol· April 2006

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Role of the retinal hydrogen bond network in rhodopsin Schiff base stability and hydrolysis.
Jay M Janz, David L Farrens

J Biol Chem· December 2004

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Rhodopsin activation exposes a key hydrophobic binding site for the transducin alpha-subunit C terminus.
Jay M Janz, David L Farrens

J Biol Chem· July 2004

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Assessing structural elements that influence Schiff base stability: mutants E113Q and D190N destabilize rhodopsin through different mechanisms.
Jay M Janz, David L Farrens

Vision Res· December 2003

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Stability of dark state rhodopsin is mediated by a conserved ion pair in intradiscal loop E-2.
Jay M Janz, Jonathan F Fay, David L Farrens

J Biol Chem· May 2003

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