Publications by authors named "Jay Matthews"

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Diastereoselective Copper-Mediated Conjugate Addition of Functionalized Magnesiates for the Preparation of Bisaryl Nrf2 Activators.
Michal P Glogowski, Jay M Matthews, Brian G Lawhorn, Kevin P C Minbiole

J Org Chem· February 2021

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Discovery of GSK3527497: A Candidate for the Inhibition of Transient Receptor Potential Vanilloid-4 (TRPV4).
Carl A Brooks, Linda S Barton, David J Behm, Edward J Brnardic, Melissa H Costell, Jay M Matthews

J Med Chem· October 2019

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Design and Optimization of Sulfone Pyrrolidine Sulfonamide Antagonists of Transient Receptor Potential Vanilloid-4 with in Vivo Activity in a Pulmonary Edema Model.
Joseph E Pero, Jay M Matthews, David J Behm, Edward J Brnardic, Carl Brooks

J Med Chem· December 2018

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Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.
Bin Zhu, Jay M Matthews, Mingde Xia, Shawn Black, Cailin Chen

Bioorg Med Chem Lett· November 2016

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Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.
Jay M Matthews, James J McNally, Peter J Connolly, Mingde Xia, Bin Zhu

Bioorg Med Chem Lett· November 2016

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Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.
Bin Zhu, Mingde Xia, Xiaoqing Xu, Donald W Ludovici, Manomi Tennakoon, Jay M Matthews

Bioorg Med Chem Lett· April 2013

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The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Jay M Matthews, Ning Qin, Raymond W Colburn, Scott L Dax, Mike Hawkins

Bioorg Med Chem Lett· April 2012

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Improvement of dyslipidemia, insulin sensitivity, and energy balance by a peroxisome proliferator-activated receptor alpha agonist.
Xiaoli Chen, Jay Matthews, Lubing Zhou, Patricia Pelton, Yin Liang

Metabolism· November 2008

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Design and synthesis of indane-ureido-thioisobutyric acids: A novel class of PPARalpha agonists.
Jay M Matthews, Xiaoli Chen, Ellen Cryan, Dennis J Hlasta, Philip J Rybczynski

Bioorg Med Chem Lett· December 2007

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Characterization of RWJ-351647, a novel nonpeptide vasopressin V2 receptor antagonist.
Joseph W Gunnet, Jay M Matthews, Bruce E Maryanoff, Lawrence de Garavilla, Patricia Andrade-Gordon

Clin Exp Pharmacol Physiol· April 2006

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Potent nonpeptide vasopressin receptor antagonists based on oxazino- and thiazinobenzodiazepine templates.
Jay M Matthews, William J Hoekstra, Alexey B Dyatkin, Leonard R Hecker, Dennis J Hlasta

Bioorg Med Chem Lett· June 2004

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Discovery of a dihydropyrimidine series of molecules that selectively mimic the biological actions of calcitonin.
Jay M Matthews, Fina Liotta, William Hageman, Ralph A Rivero, Lori Westover

Bioorg Med Chem Lett· March 2004

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Synthesis and biological evaluation of novel indoloazepine derivatives as non-peptide vasopressin V2 receptor antagonists.
Jay M Matthews, Michael N Greco, Leonard R Hecker, William J Hoekstra, Patricia Andrade-Gordon

Bioorg Med Chem Lett· February 2003

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Determination of the absolute configuration of a key tricyclic component of a novel vasopressin receptor antagonist by use of vibrational circular dichroism.
Alexey B Dyatkin, Teresa B Freedman, Xiaolin Cao, Rina K Dukor, Bruce E Maryanoff, Jay M Matthews

Chirality· April 2002

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