Publications by authors named "Jay Sarthy"

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Transcriptional rewiring by enhancer methylation in CBFA2T3-GLIS2-driven pediatric acute megakaryoblastic leukemia.
Samrat Roy Choudhury, Akhilesh Kaushal, Pritam Biswas, Cory Padilla, Jay F Sarthy

Genes Dis· January 2026

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Determining Preclinical Safety of Aclarubicin in Pediatric Malignancies.
Darleen S Tu, Aaron K Olson, Kimberly S Waggie, Nicolas M Garcia, Virginia J Hoglund, Jay F Sarthy

Pediatr Blood Cancer· November 2025

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Multimodal single-cell analyses reveal distinct fusion-regulated transcriptional programs in Ewing sarcoma.
Olivia G Waltner, April A Apfelbaum, Emma D Wrenn, Shruti S Bhise, Sami B Kanaan, Jay F Sarthy

bioRxiv· September 2025

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Determining preclinical safety of Aclarubicin in pediatric malignancies.
Darleen S Tu, Aaron K Olson, Kimberly S Waggie, Nicolas M Garcia, Virginia J Hoglund, Jay F Sarthy

bioRxiv· May 2025

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The length of the G1 phase is an essential determinant of H3K27me3 landscapes across diverse cell types.
Abby Trouth, Kameswaran Ravichandran, Philip R Gafken, Sara Martire, Gabriel E Boyle, Jay F Sarthy

PLoS Biol· April 2025

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MLL oncoprotein levels influence leukemia lineage identities.
Derek H Janssens, Melodie Duran, Dominik J Otto, Weifang Wu, Yiling Xu, Jay F Sarthy

Nat Commun· October 2024

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G1 length dictates H3K27me3 landscapes.
Abby Trouth, Kamesh Ravichandran, Philip R Gafken, Sara Martire, Gabriel E Boyle, Jay F Sarthy

bioRxiv· August 2024

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KMT2A oncoproteins induce epigenetic resistance to targeted therapies.
Derek H Janssens, Melodie Duran, Dominik J Otto, Weifang Wu, Yiling Xu, Jay F Sarthy

bioRxiv· August 2024

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Chromatin as an old and new anticancer target.
Jacques Neefjes, Katerina Gurova, Jay Sarthy, Gábor Szabó, Steven Henikoff

Trends Cancer· August 2024

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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Quy Le, Brandon Hadland, Jenny L Smith, Amanda Leonti, Benjamin J Huang, Jay Sarthy

J Clin Invest· August 2024

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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks.
Carla A Jaeger-Ruckstuhl, Yun Lo, Elena Fulton, Olivia G Waltner, Tamer B Shabaneh, Jay F Sarthy

Immunity· February 2024

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Chromatin Profiling of CBFA2T3-GLIS2 AMLs Identifies Key Transcription Factor Dependencies and BRG1 Inhibition as a Novel Therapeutic Strategy.
Samantha Kaonis, Jenny L Smith, Neerja Katiyar, Morgan Merrill, Tiffany Hyelkma, Jay F Sarthy

bioRxiv· September 2023

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Nucleosome Patterns in Circulating Tumor DNA Reveal Transcriptional Regulation of Advanced Prostate Cancer Phenotypes.
Navonil De Sarkar, Robert D Patton, Anna-Lisa Doebley, Brian Hanratty, Mohamed Adil, Jay F Sarthy

Cancer Discov· March 2023

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CBFA2T3-GLIS2 model of pediatric acute megakaryoblastic leukemia identifies FOLR1 as a CAR T cell target.
Quy Le, Brandon Hadland, Jenny L Smith, Amanda Leonti, Benjamin J Huang, Jay Sarthy

J Clin Invest· November 2022

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EWS::FLI1 and HOXD13 Control Tumor Cell Plasticity in Ewing Sarcoma.
April A Apfelbaum, Feinan Wu, Allegra G Hawkins, Brian Magnuson, Jennifer A Jiménez, Jay F Sarthy

Clin Cancer Res· October 2022

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dCas9 fusion to computer-designed PRC2 inhibitor reveals functional TATA box in distal promoter region.
Shiri Levy, Logeshwaran Somasundaram, Infencia Xavier Raj, Diego Ic-Mex, Ashish Phal, Jay Sarthy

Cell Rep· March 2022

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Automated CUT&Tag profiling of chromatin heterogeneity in mixed-lineage leukemia.
Derek H Janssens, Michael P Meers, Steven J Wu, Ekaterina Babaeva, Soheil Meshinchi, Jay F Sarthy

Nat Genet· November 2021

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Single-cell CUT&Tag analysis of chromatin modifications in differentiation and tumor progression.
Steven J Wu, Scott N Furlan, Anca B Mihalas, Hatice S Kaya-Okur, Abdullah H Feroze, Jay F Sarthy

Nat Biotechnol· July 2021

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Molecularly Targeted Treatments for NF1-Mutant Diffuse Intrinsic Pontine Glioma.
Nicholas A Vitanza, Hedieh Khalatbari, Ralph Ermoian, Jay Sarthy, Christina M Lockwood

J Appl Lab Med· March 2021

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Optimal therapeutic targeting by HDAC inhibition in biopsy-derived treatment-naïve diffuse midline glioma models.
Nicholas A Vitanza, Matt C Biery, Carrie Myers, Eric Ferguson, Ye Zheng, Jay Sarthy

Neuro Oncol· March 2021

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Short H2A histone variants are expressed in cancer.
Guo-Liang Chew, Marie Bleakley, Robert K Bradley, Harmit S Malik, Steven Henikoff, Jay Sarthy

Nat Commun· January 2021

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Histone deposition pathways determine the chromatin landscapes of H3.1 and H3.3 K27M oncohistones.
Jay F Sarthy, Michael P Meers, Derek H Janssens, Jorja G Henikoff, Heather Feldman

Elife· September 2020

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Endolymphatic exclusion for the treatment of pediatric chylous ascites secondary to neuroblastoma resection: report of two cases.
Andrew Woerner, David S Shin, Jeffrey Forris Beecham Chick, Caitlin A Smith, Jay F Sarthy

Radiol Case Rep· July 2020

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MYCN amplification and ATRX mutations are incompatible in neuroblastoma.
Maged Zeineldin, Sara Federico, Xiang Chen, Yiping Fan, Beisi Xu, Jay F Sarthy

Nat Commun· February 2020

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Response to Pembrolizumab in a Patient With Xeroderma Pigmentosum and Advanced Squamous Cell Carcinoma.
Angela Steineck, Niklas Krumm, Jay F Sarthy, Colin C Pritchard, Teresa Chapman

JCO Precis Oncol· September 2019

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