Publications by authors named "Jayanth Chandran"

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Pharmacokinetics of AAV9 Mediated Trastuzumab Expression in Rat Brain Following Systemic and Local Administration.
Ekram Ahmed Chowdhury, Manuj Ahuja, Shengjia Wu, Shufang Liu, Hsien Wei Huang, Jayanth Chandran

J Pharm Sci· January 2024

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Assessment of AAV9 distribution and transduction in rats after administration through Intrastriatal, Intracisterna magna and Lumbar Intrathecal routes.
Jayanth Chandran, Ekram Ahmed Chowdhury, Michael Perkinton, Tanguy Jamier, Daniel Sutton

Gene Ther· February 2023

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Current progress and limitations of AAV mediated delivery of protein therapeutic genes and the importance of developing quantitative pharmacokinetic/pharmacodynamic (PK/PD) models.
Ekram Ahmed Chowdhury, Guy Meno-Tetang, Hsueh Yuan Chang, Shengjia Wu, Hsien Wei Huang, Jayanth Chandran

Adv Drug Deliv Rev· March 2021

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Gene Therapy in the Nervous System: Failures and Successes.
Jayanth S Chandran, Joseph M Scarrott, Pamela J Shaw, Mimoun Azzouz

Adv Exp Med Biol· April 2018

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Site Specific Modification of Adeno-Associated Virus Enables Both Fluorescent Imaging of Viral Particles and Characterization of the Capsid Interactome.
Jayanth S Chandran, Paul S Sharp, Evangelia Karyka, João Miguel da Conceição Aves-Cruzeiro, Ian Coldicott

Sci Rep· November 2017

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C9orf72 expansion disrupts ATM-mediated chromosomal break repair.
Callum Walker, Saul Herranz-Martin, Evangelia Karyka, Chunyan Liao, Katherine Lewis, Jayanth Chandran

Nat Neurosci· September 2017

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Viral delivery of hexanucleotide repeat expansions in mice leads to repeat-length-dependent neuropathology and behavioural deficits.
Saul Herranz-Martin, Jayanth Chandran, Katherine Lewis, Padraig Mulcahy, Adrian Higginbottom

Dis Model Mech· July 2017

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SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Guillaume M Hautbergue, Lydia M Castelli, Laura Ferraiuolo, Alvaro Sanchez-Martinez, Johnathan Cooper-Knock, Jayanth S Chandran

Nat Commun· July 2017

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Disc1 variation leads to specific alterations in adult neurogenesis.
Jayanth S Chandran, Ilias Kazanis, Steven J Clapcote, Fumiaki Ogawa, J Kirsty Millar

PLoS One· June 2015

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Perspectives on disrupted-inschizophrenia 1 signaling in neurogenesis.
Jayanth S Chandran

Neural Regen Res· April 2015

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Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin.
Chen Lai, Chengsong Xie, Hoon Shim, Jayanth Chandran, Brian W Howell

Mol Brain· July 2009

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DJ-1 is essential for long-term depression at hippocampal CA1 synapses.
Yue Wang, Jayanth S Chandran, Huaibin Cai, Mark P Mattson

Neuromolecular Med· December 2008

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ALS2/alsin knockout mice and motor neuron diseases.
Huaibin Cai, Hoon Shim, Chen Lai, Chengsong Xie, Xian Lin, Jayanth Chandran

Neurodegener Dis· December 2008

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RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways.
Marcel P van der Brug, Jeff Blackinton, Jayanth Chandran, Ling-Yang Hao, Ashish Lal

Proc Natl Acad Sci U S A· July 2008

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Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function.
Jayanth S Chandran, Xian Lin, Agustin Zapata, Ahmet Höke, Mika Shimoji

Neurobiol Dis· March 2008

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The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2.
Lizhen Wang, Chengsong Xie, Elisa Greggio, Loukia Parisiadou, Hoon Shim, Jayanth Chandran

J Neurosci· March 2008

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Alsin and the molecular pathways of amyotrophic lateral sclerosis.
Jayanth Chandran, Jinhui Ding, Huaibin Cai

Mol Neurobiol· December 2007

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The G59S mutation in p150(glued) causes dysfunction of dynactin in mice.
Chen Lai, Xian Lin, Jayanth Chandran, Hoon Shim, Wan-Jou Yang

J Neurosci· December 2007

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Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans.
Joyce van de Leemput, Jayanth Chandran, Melanie A Knight, Lynne A Holtzclaw, Sonja Scholz

PLoS Genet· June 2007

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Mad fly disease.
Jayanth Chandran, Patrick Lewis

J Neurosci· January 2007

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Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking.
Chen Lai, Chengsong Xie, Stefanie G McCormack, Hsueh-Cheng Chiang, Marta K Michalak, Jayanth Chandran

J Neurosci· November 2006

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L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system.
David W Miller, Rili Ahmad, Stephen Hague, Melisa J Baptista, Rosa Canet-Aviles, Jayanth Chandran

J Biol Chem· September 2003

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