Publications by authors named "Jean Pierre-Valentin"

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Results from an EFPIA, JPMA, PhRMA industry survey on reopening and revamping the ICH S7A guidance on safety and secondary pharmacology.
Jean-Pierre Valentin, Katsuyoshi Chiba, Derek J Leishman, Emma Pawluk, Hugo M Vargas

J Pharmacol Toxicol Methods· September 2025

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Current practices on the measurement of electrocardiogram and hemodynamic parameters in non-rodent species in regulatory safety assessment studies.
Jean-Pierre Valentin, Todd Bourcier, Xuan Chi, Annie Delaunois, C Michael Foley

J Pharmacol Toxicol Methods· September 2025

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Toxicology and safety pharmacology investigations on the nervous system: 2024 industry survey.
Simon Authier, Marcus S Delatte, Alison Wakeford, Wendy Halpern, Owen McMaster

J Pharmacol Toxicol Methods· September 2025

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Corrigendum to "Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As" [J. Pharmacol. Toxicol. Methods 123 (2023) 107270].
Eric I Rossman, Todd A Wisialowski, Hugo M Vargas, Jean-Pierre Valentin, Michael G Rolf

J Pharmacol Toxicol Methods· September 2025

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Points to consider for revising the ICH S7A guideline on safety and secondary pharmacology.
Jean-Pierre Valentin, Derek Leishman

Regul Toxicol Pharmacol· June 2025

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Shaping secondary pharmacology panels of the future: evolving target selection criteria for safety panels.
Friedemann Schmidt, Richard J Brennan, Steve Jenkinson, Jean-Pierre Valentin

Nat Rev Drug Discov· June 2025

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A comprehensive review of 20 years of progress in nonclinical QT evaluation and proarrhythmic assessment.
Eric Delpy, Anne-Marie Bétat, Annie Delaunois, Christophe Drieu la Rochelle, Eric Martel

J Pharmacokinet Pharmacodyn· May 2025

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Importance of tailored non-clinical safety testing of novel antimalarial drugs: Industry best-practice.
Philip Hewitt, Andreas Hartmann, Belen Tornesi, Sandrine Ferry-Martin, Jean-Pierre Valentin

Regul Toxicol Pharmacol· December 2024

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An overview of drug-induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety.
Khuram W Chaudhary, Colleen E Clancy, Pei-Chi Yang, Jennifer B Pierson, Alan L Goldin

Clin Transl Sci· December 2024

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Deconvoluting and derisking QRS complex widening to improve cardiac safety profile of novel plasmepsin X antimalarials.
Annie Delaunois, Alvaro Cardenas, Teresa de Haro, Helga H J Gerets, Vitalina Gryshkova

Toxicol Sci· October 2024

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Assessing the interplay between off-target promiscuity, cytotoxicity, and tolerability in rodents to improve the safety profile of novel anti-malarial plasmepsin X inhibitors.
Helga H J Gerets, Annie Delaunois, Alvaro Cardenas, Reiner Class, Renaud Fleurance

Toxicol Sci· October 2024

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Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium.
Emmanuel Boulay, Simon Authier, Theresa Bartko, Andrea Greiter-Wilke, Derek Leishman

J Pharmacol Toxicol Methods· September 2024

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Endeavours made by trade associations, pharmaceutical companies and regulators in the replacement, reduction and refinement of animal experimentation in safety testing of pharmaceuticals.
Andrew W Harrell, Kirsty Reid, John Vahle, Frederic Brouta, Mario Beilmann

Regul Toxicol Pharmacol· September 2024

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Results from a Joined Prospective Study to Evaluate the Sensitivity of the In Vivo Dog QT Assay in Line with the ICH E14/S7B Q&A Best Practices.
Anne-Marie Bétat, Annie Delaunois, Eric Delpy, Mathilde Loiseau, Anne Maurin

Clin Pharmacol Ther· July 2024

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The state of the art in secondary pharmacology and its impact on the safety of new medicines.
Richard J Brennan, Stephen Jenkinson, Andrew Brown, Annie Delaunois, Bérengère Dumotier

Nat Rev Drug Discov· July 2024

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Author Correction: The state of the art in secondary pharmacology and its impact on the safety of new medicines.
Richard J Brennan, Stephen Jenkinson, Andrew Brown, Annie Delaunois, Bérengère Dumotier

Nat Rev Drug Discov· July 2024

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Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis.
Emma Pawluk, Annie Delaunois, Bastien Gamboa, Jean-Pierre Valentin

J Pharmacol Toxicol Methods· July 2024

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Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee.
Jennifer B Pierson, Brian Berridge, Ksenia Blinova, Marjory B Brooks, Sandy Eldridge

J Pharmacol Toxicol Methods· June 2024

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Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment.
Arianna Bassan, Ronald Steigerwalt, Douglas Keller, Lisa Beilke, Paul M Bradley

Front Toxicol· April 2024

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"Appraisal of state-of-the-art" The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead.
Jean-Pierre Valentin, Alicia Sibony, Marie-Luce Rosseels, Annie Delaunois

J Pharmacol Toxicol Methods· November 2023

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Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As.
Eric I Rossman, Todd A Wisialowski, Hugo M Vargas, Jean-Pierre Valentin, Michael G Rolf

J Pharmacol Toxicol Methods· November 2023

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Design of Novel Series of Antimalarial PMX Inhibitors with Increased Half-Life via Molecular Property Optimization.
Komei Sakata, Martin A Lowe, Mengyang Xuan, Jeffrey Bruffaerts, Luigi P Stasi

ACS Med Chem Lett· November 2023

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Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute.
Hugo M Vargas, Eric I Rossman, Todd A Wisialowski, Jill Nichols, Michael K Pugsley

J Pharmacol Toxicol Methods· May 2023

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2000-2023 over two decades of ICH S7A: has the time come for a revamp?
Jean-Pierre Valentin, Derek Leishman

Regul Toxicol Pharmacol· March 2023

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Setup of human liver-chips integrating 3D models, microwells and a standardized microfluidic platform as proof-of-concept study to support drug evaluation.
Benoit Cox, Patrick Barton, Reiner Class, Hannah Coxhead, Claude Delatour

Biomater Biosyst· August 2022

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