Publications by authors named "Jennifer B Pierson"

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Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment.
Ruth A Roberts, Mamta Behl, Helena T Hogberg, Eduardo Dunayevich, Michael Morton, Jennifer B Pierson

Drug Discov Today· December 2025

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Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development.
Jennifer Beck Pierson, Anthony Bahinski, Brian Berridge, Daniel Bramham, Todd Bourcier

Int J Toxicol· November 2025

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Evaluation of Biomarkers to Detect Early Prothrombotic Imbalance in Rat Models of Hypercoagulability Induced by Thromboplastin Infusion and Hypofibrinolysis Induced by Tranexamic Acid.
Marjory B Brooks, Cindy E Fishman, Mohanapriya Kamalakannan, Paula Katavolos, Claire E O'Brien, Jennifer B Pierson

Toxicol Pathol· October 2025

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Multi-laboratory comparisons of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices.
Claudia Alvarez Baron, Jun Zhao, Huimei Yu, Ming Ren, Nicolas Thiebaud, Jennifer Beck Pierson

Sci Rep· August 2025

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An overview of drug-induced sodium channel blockade and changes in cardiac conduction: Implications for drug safety.
Khuram W Chaudhary, Colleen E Clancy, Pei-Chi Yang, Jennifer B Pierson, Alan L Goldin

Clin Transl Sci· December 2024

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Detection of contractility changes in the heart from arterial blood pressure data using symmetric Projection Attractor Reconstruction.
Esther Bonet-Luz, Manasi Nandi, Mark I Christie, Jennifer Doyle, Jennifer B Pierson

J Pharmacol Toxicol Methods· September 2024

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Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee.
Jennifer B Pierson, Brian Berridge, Ksenia Blinova, Marjory B Brooks, Sandy Eldridge

J Pharmacol Toxicol Methods· June 2024

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The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis.
Emmanuel Boulay, Loïs S Miraucourt, Michael K Pugsley, Matthew M Abernathy, Ray Chui, Jennifer B Pierson

J Pharmacol Toxicol Methods· May 2023

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Use of the ZDF rat to model dietary fat induced hypercoagulability is limited by progressive and fatal nephropathy.
Michael K Pugsley, Marjory B Brooks, Cindy E Fishman, Paula Katavolos, Alan Y Chiang, Jennifer B Pierson

J Pharmacol Toxicol Methods· November 2021

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Can We Panelize Seizure?
Ruth Roberts, Simon Authier, R Daniel Mellon, Michael Morton, Ikuro Suzuki, Jennifer B Pierson

Toxicol Sci· January 2021

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Repolarization studies using human stem cell-derived cardiomyocytes: Validation studies and best practice recommendations.
Gary Gintant, Emily Pfeiffer Kaushik, Tromondae Feaster, Sonja Stoelzle-Feix, Yasunari Kanda, Jennifer Beck Pierson

Regul Toxicol Pharmacol· November 2020

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Echocardiographic and hemodynamic indices of myocardial contractility simultaneously evaluated in telemetered beagle dogs: A HESI-sponsored cross-company evaluation.
Eric I Rossman, Frank Cools, Jason Cordes, Deborah Dhuyvetter, Jennifer M Doyle, Jennifer B Pierson

J Pharmacol Toxicol Methods· September 2020

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Publisher Correction: Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
James Kramer, Herbert M Himmel, Anders Lindqvist, Sonja Stoelzle-Feix, Khuram W Chaudhary, Jennifer Beck Pierson

Sci Rep· July 2020

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Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells.
James Kramer, Herbert M Himmel, Anders Lindqvist, Sonja Stoelzle-Feix, Khuram W Chaudhary, Jennifer Beck Pierson

Sci Rep· March 2020

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Considerations for an , Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms.
Brian D Guth, Michael Engwall, Sandy Eldridge, C Michael Foley, Liang Guo, Jennifer B Pierson

Front Pharmacol· August 2019

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Considerations for an , Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes.
Alexandre J S Ribeiro, Brian D Guth, Michael Engwall, Sandy Eldridge, C Michael Foley, Jennifer B Pierson

Front Pharmacol· August 2019

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An evaluation of the utility of LVdP/dt, QA interval, LVdP/dt and Tau as indicators of drug-induced changes in contractility and lusitropy in dogs.
Michael K Pugsley, Brian Guth, Alan Y Chiang, Jennifer M Doyle, Michael Engwall, Jennifer Beck Pierson

J Pharmacol Toxicol Methods· April 2018

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Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.
Syed Z Imam, Zhen He, Elvis Cuevas, Hector Rosas-Hernandez, Susan M Lantz, Jennifer B Pierson

Exp Biol Med (Maywood)· February 2018

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Can non-clinical repolarization assays predict the results of clinical thorough QT studies? Results from a research consortium.
Eunjung Park, Gary A Gintant, Daoqin Bi, Devi Kozeli, Syril D Pettit, Jennifer B Pierson

Br J Pharmacol· February 2018

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Cardiac contractility: Correction strategies applied to telemetry data from a HESI-sponsored consortium.
Emmanuel Boulay, Michael K Pugsley, Vincent Jacquemet, Alain Vinet, Michael V Accardi, Jennifer Beck Pierson

J Pharmacol Toxicol Methods· September 2017

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Non-Lethal Endotoxin Injection: A Rat Model of Hypercoagulability.
Marjory B Brooks, James R Turk, Abraham Guerrero, Padma K Narayanan, John P Nolan, Jennifer B Pierson

PLoS One· August 2017

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The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative - Update on progress.
Thomas Colatsky, Bernard Fermini, Gary Gintant, Jennifer B Pierson, Philip Sager

J Pharmacol Toxicol Methods· May 2017

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The evaluation of drug-induced changes in cardiac inotropy in dogs: Results from a HESI-sponsored consortium.
Brian D Guth, Alan Y Chiang, Jennifer Doyle, Michael J Engwall, Jean-Michel Guillon, Jennifer Beck Pierson

J Pharmacol Toxicol Methods· July 2016

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Evaluating uncertainty to strengthen epidemiologic data for use in human health risk assessments.
Carol J Burns, J Michael Wright, Jennifer B Pierson, Thomas F Bateson, Igor Burstyn

Environ Health Perspect· November 2014

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A public-private consortium advances cardiac safety evaluation: achievements of the HESI Cardiac Safety Technical Committee.
Jennifer B Pierson, Brian R Berridge, Marjory B Brooks, Kevin Dreher, John Koerner

J Pharmacol Toxicol Methods· February 2014

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