Publications by authors named "Jean-Pierre Issa"

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DNA Methylation, Aging, and Cancer.
Himani Vaidya, Jaroslav Jelinek, Jean-Pierre J Issa

Epigenomes· June 2025

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A phase 2 study of decitabine with or without carboplatin and arsenic trioxide in patients with MDS and AML.
Patricia L Kropf, Woonbok Chung, Raji Shameem, Lianchun Xiao, Curt Balch, Jean-Pierre J Issa

Blood Neoplasia· May 2025

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ZNFX1 Functions as a Master Regulator of Epigenetically Induced Pathogen Mimicry and Inflammasome Signaling in Cancer.
Lora Stojanovic, Rachel Abbotts, Kaushelendra Tripathi, Collin M Coon, Saranya Rajendran, Jean-Pierre J Issa

Cancer Res· April 2025

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CDK9 degradation Inhibits Gastroesophageal Cancer growth and Overcomes Radiation Resistance by Increasing Chromatin Accessibility and Downregulating YAP1/TEAD signaling.
Yan-Ting Yann Zhang, Mikel Ghelfi, Yu Xue, Haiying Chen, Gennaro Calendo, Jean-Pierre Issa

bioRxiv· February 2025

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Bone marrow microenvironment signatures associate with patient survival after guadecitabine and atezolizumab therapy in HMA-resistant MDS.
H Josh Jang, Guillermo Urrutia, Andreas Due Orskov, Hyeon Jin Kim, Seth A Nelson, Jean-Pierre J Issa

bioRxiv· November 2024

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ZNFX1 is a Novel Master Regulator in Epigenetically-induced Pathogen Mimicry and Inflammasome Signaling in Cancer.
Lora Stojanovic, Rachel Abbotts, Kaushlendra Tripathi, Collin M Coon, Saranya Rajendran, Jean-Pierre Issa

bioRxiv· October 2024

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Association between gut microbiota and CpG island methylator phenotype in colorectal cancer.
Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Jean-Pierre J Issa

Gut Microbes· June 2024

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Genome-wide screening and functional validation of methylation barriers near promoters.
Jingmin Shu, Jaroslav Jelinek, Hai Chen, Yan Zhang, Taichun Qin, Jean-Pierre J Issa

Nucleic Acids Res· May 2024

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Tissue-infiltrating alloreactive T cells require Id3 to deflect PD-1-mediated immune suppression during GVHD.
Ying Wang, Shan He, Gennaro Calendo, Tien Bui, Yuanyuan Tian, Jean-Pierre Issa

Blood· January 2024

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MC180295 is a highly potent and selective CDK9 inhibitor with preclinical in vitro and in vivo efficacy in cancer.
Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Jean-Pierre J Issa

Clin Epigenetics· January 2024

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Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa.
Ang Sun, Pyounghwa Park, Lauren Cole, Himani Vaidya, Shinji Maegawa, Jean-Pierre J Issa

Epigenetics· December 2023

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Postmortem toxicology findings from the Camden Opioid Research Initiative.
Dara M Kusic, Jessica Heil, Stefan Zajic, Andrew Brangan, Oluseun Dairo, Alissa Resch, Jean-Pierre J Issa

PLoS One· November 2023

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Guadecitabine vs treatment choice in newly diagnosed acute myeloid leukemia: a global phase 3 randomized study.
Pierre Fenaux, Marco Gobbi, Patricia L Kropf, Jean-Pierre J Issa, Gail J Roboz

Blood Adv· September 2023

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A Phase II Trial of Guadecitabine plus Atezolizumab in Metastatic Urothelial Carcinoma Progressing after Initial Immune Checkpoint Inhibitor Therapy.
H Josh Jang, Galen Hostetter, Alexander W Macfarlane, Zachary Madaj, Eric A Ross, Jean-Pierre J Issa

Clin Cancer Res· June 2023

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TET1 and TDG Suppress Inflammatory Response in Intestinal Tumorigenesis: Implications for Colorectal Tumors With the CpG Island Methylator Phenotype.
Rossella Tricarico, Jozef Madzo, Gabrielle Scher, Maya Cohen, Jaroslav Jelinek, Jean-Pierre Issa

Gastroenterology· May 2023

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Author Correction: DNA methylation entropy as a measure of stem cell replication and aging.
Himani Vaidya, Hye Seon Jeong, Kelsey Keith, Shinji Maegawa, Gennaro Calendo, Jean-Pierre J Issa

Genome Biol· April 2023

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DNA methylation entropy as a measure of stem cell replication and aging.
Himani Vaidya, Hye Seon Jeong, Kelsey Keith, Shinji Maegawa, Gennaro Calendo, Jean-Pierre J Issa

Genome Biol· February 2023

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Hypomethylation in MTNR1B: a novel epigenetic marker for atherosclerosis profiling using stenosis radiophenotype and blood inflammatory cells.
Jee Yeon Kim, Jaroslav Jelinek, Young Ho Lee, Dae Hyun Kim, Keunsoo Kang, Jean-Pierre J Issa

Clin Epigenetics· January 2023

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Safety, Outcomes, and T-Cell Characteristics in Patients with Relapsed or Refractory MDS or CMML Treated with Atezolizumab in Combination with Guadecitabine.
Casey L O'Connell, Maria R Baer, Andreas Due Ørskov, Sunil Kumar Saini, Vu H Duong, Jean-Pierre Issa

Clin Cancer Res· December 2022

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Epigenome-Wide Study Identifies Epigenetic Outliers in Normal Mucosa of Patients with Colorectal Cancer.
Jayashri Ghosh, Bryant M Schultz, Joe Chan, Claudia Wultsch, Rajveer Singh, Melissa Driscoll, Jean-Pierre J Issa

Cancer Prev Res (Phila)· November 2022

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Prospective comparison of outcomes with azacitidine and decitabine in patients with AML ineligible for intensive chemotherapy.
Amer M Zeidan, Pierre Fenaux, Marco Gobbi, Jiří Mayer, Gail J Roboz, Jean-Pierre J Issa

Blood· July 2022

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Selective CDK9 Inhibition by Natural Compound Toyocamycin in Cancer Cells.
Somnath Pandey, Rahinatou Djibo, Anaïs Darracq, Gennaro Calendo, Hanghang Zhang, Jean-Pierre J Issa

Cancers (Basel)· July 2022

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The Two-Hit Hypothesis Meets Epigenetics.
Jean-Pierre Issa

Cancer Res· April 2022

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The Roles of DNA Demethylases in Triple-Negative Breast Cancer.
Shoghag Panjarian, Jean-Pierre J Issa

Pharmaceuticals (Basel)· June 2021

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Accelerated aging in normal breast tissue of women with breast cancer.
Shoghag Panjarian, Jozef Madzo, Kelsey Keith, Carolyn M Slater, Carmen Sapienza, Jean-Pierre J Issa

Breast Cancer Res· May 2021

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