Publications by authors named "Jeffrey Bemis"

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Erythrocyte-Based Pig-a Gene Mutation Assay.
Jeffrey C Bemis, Nikki E Hall, Stephen D Dertinger

Methods Mol Biol· November 2025

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Application of Biological Modifiers to a Multiplexed, Human Cell-Based DNA Damage Assay Provides Mechanistic Information on Genotoxicity and Molecular Targets.
Steven M Bryce, Svetlana L Avlasevich, Adam Conrad, Nikki E Hall, Kyle Tichenor, Jeffrey C Bemis

Environ Mol Mutagen· June 2025

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Mitigation of Volatile Chemicals' Effect on Adjacent Microtiter Plate Wells.
Svetlana L Avlasevich, Erica Briggs, Kyle Tichenor, Adam Conrad, Nikki Hall, Jeffrey C Bemis

Environ Mol Mutagen· March 2025

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Visualization strategies to aid interpretation of high-dimensional genotoxicity data.
Stephen D Dertinger, Erica Briggs, Yusuf Hussien, Steven M Bryce, Svetlana L Avlasevich, Jeffrey C Bemis

Environ Mol Mutagen· June 2024

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Lack of hydroxyurea-associated mutagenesis in pediatric sickle cell disease patients.
Dorothea K Torous, Svetlana Avlasevich, Jeffrey C Bemis, Thad Howard, Russell E Ware

Environ Mol Mutagen· March 2023

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Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose.
Marc A Beal, Marc Audebert, Tara Barton-Maclaren, Hannah Battaion, Jeffrey C Bemis

Environ Mol Mutagen· February 2023

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A cross-sectional clinical study in women to investigate possible genotoxicity and hematological abnormalities related to the use of black cohosh botanical dietary supplements.
Stephanie L Smith-Roe, Stavros Garantziotis, Rebecca L Church, Jeffrey C Bemis, Dorothea K Torous

Environ Mol Mutagen· December 2022

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In vitro human cell-based aneugen molecular mechanism assay.
Nikki E Hall, Kyle Tichenor, Steven M Bryce, Jeffrey C Bemis, Stephen D Dertinger

Environ Mol Mutagen· March 2022

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Biomarkers of DNA damage response improve in vitro micronucleus assays by revealing genotoxic mode of action and reducing the occurrence of irrelevant positive results.
Svetlana Avlasevich, Tina Pellegrin, Manali Godse, Steven Bryce, Jeffrey Bemis

Mutagenesis· November 2021

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Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity.
Steven M Bryce, Stephen D Dertinger, Jeffrey C Bemis

Mutagenesis· July 2021

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The use of benchmark dose uncertainty measurements for robust comparative potency analyses.
Ryan P Wheeldon, Stephen D Dertinger, Steven M Bryce, Jeffrey C Bemis, George E Johnson

Environ Mol Mutagen· March 2021

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Assessment of systemic genetic damage in pediatric inflammatory bowel disease.
Ayesha Baig, Svetlana L Avlasevich, Dorothea K Torous, Jeffrey C Bemis, Lawrence J Saubermann

Environ Mol Mutagen· November 2020

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Human blood PIG-A mutation and micronucleated reticulocyte flow cytometric assays: Method optimization and evaluation of intra- and inter-subject variation.
Dorothea K Torous, Svetlana L Avlasevich, Mona G Khattab, Ayesha Baig, Lawrence J Saubermann, Jeffrey C Bemis

Environ Mol Mutagen· October 2020

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Intra- and inter-laboratory reproducibility of the rat blood Pig-a gene mutation assay.
Stephen D Dertinger, Svetlana L Avlasevich, Dorothea K Torous, Jeffrey C Bemis, Tamsanqa Tafara Hove

Environ Mol Mutagen· June 2020

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Erythrocyte-Based Pig-a Gene Mutation Assay.
Jeffrey C Bemis, Nikki E Hall, Stephen D Dertinger

Methods Mol Biol· April 2020

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Benchmark Dose Analysis of DNA Damage Biomarker Responses Provides Compound Potency and Adverse Outcome Pathway Information for the Topoisomerase II Inhibitor Class of Compounds.
Ryan P Wheeldon, Derek T Bernacki, Stephen D Dertinger, Steven M Bryce, Jeffrey C Bemis

Environ Mol Mutagen· April 2020

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3Rs-friendly approach to exogenous metabolic activation that supports high-throughput genetic toxicology testing.
Shuchang Tian, Aiyana Cyr, Karen Zeise, Steven M Bryce, Nikki Hall, Jeffrey C Bemis

Environ Mol Mutagen· April 2020

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Dextran sulfate sodium mouse model of inflammatory bowel disease evaluated for systemic genotoxicity via blood micronucleus and Pig-a gene mutation assays.
Christopher Kirby, Ayesha Baig, Svetlana L Avlasevich, Dorothea K Torous, Shuchang Tian, Jeffrey C Bemis

Mutagenesis· March 2020

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Evidence for an Aneugenic Mechanism of Action for Micronucleus Induction by Black Cohosh Extract.
Derek T Bernacki, Steven M Bryce, Jeffrey C Bemis, Stephen D Dertinger, Kristine L Witt

Environ Mol Mutagen· December 2019

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3Rs friendly study designs facilitate rat liver and blood micronucleus assays and Pig-a gene mutation assessments: Proof-of-concept with 13 reference chemicals.
Stephen D Dertinger, Svetlana L Avlasevich, Dorothea K Torous, Priyanka Singh, Sumee Khanal, Jeffrey C Bemis

Environ Mol Mutagen· October 2019

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Aneugen Molecular Mechanism Assay: Proof-of-Concept With 27 Reference Chemicals.
Derek T Bernacki, Steven M Bryce, Jeffrey C Bemis, Stephen D Dertinger

Toxicol Sci· August 2019

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Predictions of genotoxic potential, mode of action, molecular targets, and potency via a tiered multiflow® assay data analysis strategy.
Stephen D Dertinger, Andrew R Kraynak, Ryan P Wheeldon, Derek T Bernacki, Steven M Bryce, Jeffrey C Bemis

Environ Mol Mutagen· July 2019

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Suitability of Long-Term Frozen Rat Blood Samples for the Interrogation of Pig-a Gene Mutation by Flow Cytometry.
Svetlana L Avlasevich, Dorothea K Torous, Jeffrey C Bemis, Javed A Bhalli, Cameron C Tebbe

Environ Mol Mutagen· January 2019

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Flow cytometric method for scoring rat liver micronuclei with simultaneous assessments of hepatocyte proliferation.
Svetlana L Avlasevich, Sumee Khanal, Priyanka Singh, Dorothea K Torous, Jeffrey C Bemis

Environ Mol Mutagen· April 2018

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Integration of liver and blood micronucleus and Pig-a gene mutation endpoints into rat 28-day repeat-treatment studies: Proof-of-principle with diethylnitrosamine.
Sumee Khanal, Priyanka Singh, Svetlana L Avlasevich, Dorothea K Torous, Jeffrey C Bemis

Mutat Res Genet Toxicol Environ Mutagen· April 2018

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