Publications by authors named "Jeffrey Jerman"

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A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels.
David McCoull, Emma Ococks, Jonathan M Large, David C Tickle, Alistair Mathie, Jeffrey Jerman

SLAS Discov· March 2021

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Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.
Paul D Wright, Emma L Veale, David McCoull, David C Tickle, Jonathan M Large, Jeffrey Jerman

Biochem Biophys Res Commun· November 2017

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Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3.
Trinidad Montero-Melendez, Rachel A E Forfar, Jennifer M Cook, Jeffrey C Jerman, Debra L Taylor

Cell Mol Life Sci· April 2017

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A High-Throughput Electrophysiology Assay Identifies Inhibitors of the Inwardly Rectifying Potassium Channel Kir7.1.
Paul D Wright, Srinivasan Kanumilli, David Tickle, Jamie Cartland, Nathalie Bouloc, Jeffrey C Jerman

J Biomol Screen· July 2015

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Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.
Susan M Westaway, Mervyn Thompson, Harshad K Rami, Geoffrey Stemp, Leontine S Trouw, Jeffrey C Jerman

Bioorg Med Chem Lett· October 2008

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Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Martin J Gunthorpe, Sara Luis Hannan, Darren Smart, Jeffrey C Jerman, Sandra Arpino

J Pharmacol Exp Ther· June 2007

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N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.
Susan M Westaway, Ying-Kit Chung, John B Davis, Vicky Holland, Jeffrey C Jerman

Bioorg Med Chem Lett· September 2006

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Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Harshad K Rami, Mervyn Thompson, Geoffrey Stemp, Steve Fell, Jeffrey C Jerman

Bioorg Med Chem Lett· June 2006

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Discovery of small molecule antagonists of TRPV1.
Harshad K Rami, Mervyn Thompson, Paul Wyman, Jeffrey C Jerman, Julie Egerton

Bioorg Med Chem Lett· July 2004

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Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.
Christopher J Langmead, Jeffrey C Jerman, Stephen J Brough, Claire Scott, Rod A Porter

Br J Pharmacol· January 2004

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Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.
Christopher J Fowler, Kent-Olov Jonsson, Anna Andersson, Juha Juntunen, Tomi Järvinen, Jeffrey C Jerman

Biochem Pharmacol· September 2003

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The physiology and pharmacology of the orexins.
Darren Smart, Jeffrey Jerman

Pharmacol Ther· March 2003

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Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors.
Vera Ralevic, Jeffrey C Jerman, Stephen J Brough, John B Davis, Julie Egerton

Biochem Pharmacol· January 2003

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