Publications by authors named "Darren Smart"

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Measurement of inositol(1,4,5)trisphosphate using a stereospecific radioreceptor mass assay.
Darren Smart

Methods Mol Biol· February 2013

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Measurement of inositol(1,4,5)trisphosphate using a stereospecific radioreceptor mass assay.
Darren Smart

Methods Mol Biol· August 2011

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Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Martin J Gunthorpe, Sara Luis Hannan, Darren Smart, Jeffrey C Jerman, Sandra Arpino

J Pharmacol Exp Ther· June 2007

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Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Harshad K Rami, Mervyn Thompson, Geoffrey Stemp, Steve Fell, Jeffrey C Jerman, Darren Smart

Bioorg Med Chem Lett· June 2006

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Measurement of inositol(1,4,5)trisphosphate using a stereospecific radioreceptor mass assay.
Darren Smart

Methods Mol Biol· February 2006

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Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain.
Steven J R Elmes, Maulik D Jhaveri, Darren Smart, David A Kendall, Victoria Chapman

Eur J Neurosci· November 2004

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Evidence for biological effects of exogenous LPA on rat primary afferent and spinal cord neurons.
Steven J R Elmes, Paul J Millns, Darren Smart, David A Kendall, Victoria Chapman

Brain Res· October 2004

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Discovery of small molecule antagonists of TRPV1.
Harshad K Rami, Mervyn Thompson, Paul Wyman, Jeffrey C Jerman, Julie Egerton, Darren Smart

Bioorg Med Chem Lett· July 2004

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TRPV1 and CB(1) receptor-mediated effects of the endovanilloid/endocannabinoid N-arachidonoyl-dopamine on primary afferent fibre and spinal cord neuronal responses in the rat.
Devi R Sagar, Paul A Smith, Paul J Millns, Darren Smart, David A Kendall

Eur J Neurosci· July 2004

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Noladin ether, a putative endocannabinoid, attenuates sensory neurotransmission in the rat isolated mesenteric arterial bed via a non-CB1/CB2 G(i/o) linked receptor.
Marnie Duncan, Paul Millns, Darren Smart, James E Wright, David A Kendall

Br J Pharmacol· June 2004

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Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats.
Daniel S McQueen, Susan M Bond, Paula J W Smith, Kia Balali-Mood, Darren Smart

Eur J Pharmacol· May 2004

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Inhibition of C6 glioma cell proliferation by anandamide, 1-arachidonoylglycerol, and by a water soluble phosphate ester of anandamide: variability in response and involvement of arachidonic acid.
Christopher J Fowler, Kent-Olov Jonsson, Anna Andersson, Juha Juntunen, Tomi Järvinen, Darren Smart

Biochem Pharmacol· September 2003

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Effects of central hypocretin-1 administration on hemodynamic responses in young-adult and middle-aged rats.
Kazuyoshi Hirota, Tetsuya Kushikata, Mihoko Kudo, Tsuyoshi Kudo, Darren Smart

Brain Res· August 2003

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The effects of local and intravenous anesthetics on recombinant rat VR1 vanilloid receptors.
Kazuyoshi Hirota, Darren Smart, David G Lambert

Anesth Analg· June 2003

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Lack of an interaction between orexinergic and opioid/nociceptinergic systems in rat cerebrocortical slices.
Kazuyoshi Hirota, Tetsuya Kushikata, Mihoko Kudo, Hirobumi Ohkawa, Tsuyoshi Kudo, Darren Smart

Neurosci Lett· April 2003

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The physiology and pharmacology of the orexins.
Darren Smart, Jeffrey Jerman

Pharmacol Ther· March 2003

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N-Morpholino- and N-diethyl-analogues of palmitoylethanolamide increase the sensitivity of transfected human vanilloid receptors to activation by anandamide without affecting fatty acid amidohydrolase activity.
Séverine Vandevoorde, Didier M Lambert, Darren Smart, Kent Olov Jonsson, Christopher J Fowler

Bioorg Med Chem· March 2003

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Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors.
Vera Ralevic, Jeffrey C Jerman, Stephen J Brough, John B Davis, Julie Egerton, Darren Smart

Biochem Pharmacol· January 2003

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Activation of vanilloid receptor 1 by resiniferatoxin mobilizes calcium from inositol 1,4,5-trisphosphate-sensitive stores.
Ian C B Marshall, Davina E Owen, Tim V Cripps, John B Davis, Shaun McNulty, Darren Smart

Br J Pharmacol· January 2003

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Cannabinoid modulation of sensory neurotransmission via cannabinoid and vanilloid receptors: roles in regulation of cardiovascular function.
Vera Ralevic, David A Kendall, Michael D Randall, Darren Smart

Life Sci· October 2002

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'Entourage' effects of N-acyl ethanolamines at human vanilloid receptors. Comparison of effects upon anandamide-induced vanilloid receptor activation and upon anandamide metabolism.
Darren Smart, Kent-Olov Jonsson, Séverine Vandevoorde, Didier M Lambert, Christopher J Fowler

Br J Pharmacol· June 2002

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Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives.
Hiroyuki Watanabe, John B Davis, Darren Smart, Jeff C Jerman, Graham D Smith

J Biol Chem· April 2002

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Orexins and the treatment of obesity.
Darren Smart, Andrea C Haynes, Gareth Williams, Jonathan R S Arch

Eur J Pharmacol· April 2002

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Identification and characterisation of functional bombesin receptors in human astrocytes.
Sarah Mason, Darren Smart, Ian C B Marshall, Alexander McKnight, Jeremy N Skepper

Eur J Pharmacol· March 2002

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