Publications by authors named "Mervyn Thompson"

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The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor.
James M Bailey, Jackie S Scott, Jonathan B Basilla, Victoria J Bolton, Izzy Boyfield, Mervyn Thompson

Bioorg Med Chem Lett· November 2009

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Discovery of N-(3-fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the first small molecule motilin receptor agonist clinical candidate.
Susan M Westaway, Samantha L Brown, Stephen C M Fell, Christopher N Johnson, David T MacPherson, Mervyn Thompson

J Med Chem· February 2009

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The discovery of biaryl carboxamides as novel small molecule agonists of the motilin receptor.
Susan M Westaway, Samantha L Brown, Elizabeth Conway, Tom D Heightman, Christopher N Johnson, Mervyn Thompson

Bioorg Med Chem Lett· December 2008

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Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1.
Susan M Westaway, Mervyn Thompson, Harshad K Rami, Geoffrey Stemp, Leontine S Trouw

Bioorg Med Chem Lett· October 2008

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Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Martin J Gunthorpe, Sara Luis Hannan, Darren Smart, Jeffrey C Jerman, Sandra Arpino, Mervyn Thompson

J Pharmacol Exp Ther· June 2007

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N-Tetrahydroquinolinyl, N-quinolinyl and N-isoquinolinyl biaryl carboxamides as antagonists of TRPV1.
Susan M Westaway, Ying-Kit Chung, John B Davis, Vicky Holland, Jeffrey C Jerman, Mervyn Thompson

Bioorg Med Chem Lett· September 2006

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Discovery of SB-705498: a potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development.
Harshad K Rami, Mervyn Thompson, Geoffrey Stemp, Steve Fell, Jeffrey C Jerman

Bioorg Med Chem Lett· June 2006

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Bicyclic heteroarylpiperazines as selective brain penetrant 5-HT6 receptor antagonists.
Mahmood Ahmed, Michael A Briggs, Steven M Bromidge, Tania Buck, Lorraine Campbell, Mervyn Thompson

Bioorg Med Chem Lett· November 2005

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Identification of a potent and selective 5-HT1B receptor antagonist.
Paul A Wyman, Howard R Marshall, Sean T Flynn, Ron J King, Mervyn Thompson

Bioorg Med Chem Lett· November 2005

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3,4-Dihydro-2H-benzoxazinones are 5-HT(1A) receptor antagonists with potent 5-HT reuptake inhibitory activity.
Peter J Atkinson, Steven M Bromidge, Mark S Duxon, Laramie M Gaster, Michael S Hadley, Mervyn Thompson

Bioorg Med Chem Lett· February 2005

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Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation.
Karen A Augustine-Rauch, Qin J Zhang, Jennifer L Leonard, Antony Chadderton, Michael J Welsh, Mervyn Thompson

Birth Defects Res A Clin Mol Teratol· October 2004

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Discovery of small molecule antagonists of TRPV1.
Harshad K Rami, Mervyn Thompson, Paul Wyman, Jeffrey C Jerman, Julie Egerton

Bioorg Med Chem Lett· July 2004

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The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents.
Nigel E Austin, Michael S Hadley, John D Harling, Frank P Harrington, Gregor J Macdonald, Mervyn Thompson

Bioorg Med Chem Lett· May 2003

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