Publications by authors named "John D Harling"

Claim this Profile
E
Expanding the reaction toolbox for nanoscale direct-to-biology PROTAC synthesis and biological evaluation.
Rebecca Stevens, Harry J Shrives, Jenni Cryan, Diana Klimaszewska, Peter Stacey, John D Harling

RSC Med Chem· March 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-Guided Design and Optimization of Covalent VHL-Targeted Sulfonyl Fluoride PROTACs.
Rishi R Shah, Elena De Vita, Preethi S Sathyamurthi, Daniel Conole, Xinyue Zhang, John D Harling

J Med Chem· March 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Integrated Direct-to-Biology Platform for the Nanoscale Synthesis and Biological Evaluation of PROTACs.
Rebecca Stevens, Enrique Bendito-Moll, David J Battersby, Afjal H Miah, Natalie Wellaway, John D Harling

J Med Chem· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A two-faced selectivity solution to target SMARCA2 for cancer therapy.
John D Harling, Christopher P Tinworth

Nat Commun· January 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
L
Light-mediated multi-target protein degradation using arylazopyrazole photoswitchable PROTACs (AP-PROTACs).
Qisi Zhang, Cyrille S Kounde, Milon Mondal, Jake L Greenfield, Jennifer R Baker, John D Harling

Chem Commun (Camb)· September 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
U
UV-DIB: label-free permeability determination using droplet interface bilayers.
Robert Strutt, Felix Sheffield, Nathan E Barlow, Anthony J Flemming, John D Harling

Lab Chip· March 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Challenges and opportunities for PROTAC delivery.
Andrew B Benowitz, Paul T Scott-Stevens, John D Harling

Future Med Chem· January 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs.
Robert P Law, Joao Nunes, Chun-Wa Chung, Marcus Bantscheff, Karol Buda, John D Harling

Angew Chem Int Ed Engl· October 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Optimization of a Series of RIPK2 PROTACs.
Afjal H Miah, Ian E D Smith, Mark Rackham, Alina Mares, Aditya R Thawani, John D Harling

J Med Chem· September 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The therapeutic potential of PROTACs.
Andrew B Benowitz, Katherine L Jones, John D Harling

Expert Opin Ther Pat· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Activating mechanosensitive channels embedded in droplet interface bilayers using membrane asymmetry.
Robert Strutt, James W Hindley, Jordan Gregg, Paula J Booth, John D Harling

Chem Sci· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structural Insights into PROTAC-Mediated Degradation of Bcl-xL.
Chun-Wa Chung, Han Dai, Esther Fernandez, Christopher P Tinworth, Ian Churcher, John D Harling

ACS Chem Biol· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A caged E3 ligase ligand for PROTAC-mediated protein degradation with light.
Cyrille S Kounde, Maria M Shchepinova, Charlie N Saunders, Marcel Muelbaier, Mark D Rackham, John D Harling

Chem Commun (Camb)· May 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2.
Alina Mares, Afjal H Miah, Ian E D Smith, Mark Rackham, Aditya R Thawani, John D Harling

Commun Biol· March 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeting IRAK4 for Degradation with PROTACs.
Joao Nunes, Grant A McGonagle, Jessica Eden, Girieshanie Kiritharan, Megane Touzet, John D Harling

ACS Med Chem Lett· July 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PROTAC-Mediated Degradation of Bruton's Tyrosine Kinase Is Inhibited by Covalent Binding.
Christopher P Tinworth, Hannah Lithgow, Lars Dittus, Zuni I Bassi, Sophie E Hughes, John D Harling

ACS Chem Biol· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins.
Dennis L Buckley, Kanak Raina, Nicole Darricarrere, John Hines, Jeffrey L Gustafson, John D Harling

ACS Chem Biol· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Catalytic in vivo protein knockdown by small-molecule PROTACs.
Daniel P Bondeson, Alina Mares, Ian E D Smith, Eunhwa Ko, Sebastien Campos, John D Harling

Nat Chem Biol· August 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of a Novel and Selective Series of Itk Inhibitors via a Template-Hopping Strategy.
Catherine M Alder, Martin Ambler, Amanda J Campbell, Aurelie C Champigny, Angela M Deakin, John D Harling

ACS Med Chem Lett· October 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of novel irreversible inhibitors of interleukin (IL)-2-inducible tyrosine kinase (Itk) by targeting cysteine 442 in the ATP pocket.
John D Harling, Angela M Deakin, Sébastien Campos, Rachel Grimley, Laiq Chaudry

J Biol Chem· September 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with aminoindane and phenylpyrrolidine P4 motifs.
Robert J Young, Carl Adams, Mike Blows, David Brown, Cynthia L Burns-Kurtis, John D Harling

Bioorg Med Chem Lett· March 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs.
Nigel S Watson, Carl Adams, David Belton, David Brown, Cynthia L Burns-Kurtis, John D Harling

Bioorg Med Chem Lett· March 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure and property based design of factor Xa inhibitors: pyrrolidin-2-ones with monoaryl P4 motifs.
Savvas Kleanthous, Alan D Borthwick, David Brown, Cynthia L Burns-Kurtis, Matthew Campbell, John D Harling

Bioorg Med Chem Lett· January 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Phosphinates as new electrophilic partners for cross-coupling reactions.
Jun Guo, John D Harling, Patrick G Steel, Tom M Woods

Org Biomol Chem· November 2008

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
One-pot synthesis of benzothiazolines and napthathiazolines via cascade ortho-lithiation, cyclisation and elimination of N-arylsulfonyl lactams.
John D Harling, Patrick G Steel, Tom M Woods, Dmitry S Yufit

Org Biomol Chem· November 2007

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis