Publications by authors named "Jeffrey Kuethe"

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Total Synthesis of Enlicitide Decanoate.
Hongming Li, David A Thaisrivongs, Gao Shang, Yonggang Chen, Qinghao Chen, Jeffrey T Kuethe

J Am Chem Soc· April 2025

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Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Douglas G Johns, Louis-Charles Campeau, Puja Banka, An Bautmans, Tjerk Bueters, Jeffrey T Kuethe

Circulation· July 2023

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Synthesis of a Complex and Highly Potent PCSK9 Inhibitor.
Jeffrey T Kuethe, Joshua Lee, David Thaisrivongs, Nobuyoshi Yasuda, Scott R Pollack

Org Lett· July 2023

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Photoredox-Catalyzed Giese Reactions: Decarboxylative Additions to Cyclic Vinylogous Amides and Esters.
Kevin Dykstra, Alexei Buevich, Qi Gao, Yu-Hong Lam, Jeffrey T Kuethe

Molecules· January 2022

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A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
Thomas J Tucker, Mark W Embrey, Candice Alleyne, Rupesh P Amin, Alan Bass, Jeffrey T Kuethe

J Med Chem· November 2021

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Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety.
Shuwen He, Zhong Lai, Qingmei Hong, Jackie Shang, Mikhail Reibarkh, Jeffrey T Kuethe

Bioorg Med Chem Lett· May 2019

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Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether.
Jeffrey T Kuethe, Kallol Basu, Robert K Orr, Eric Ashley, Marc Poirier

Bioorg Med Chem· February 2018

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Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.
Tim Cernak, Nathan J Gesmundo, Kevin Dykstra, Yang Yu, Zhicai Wu, Jeffrey Kuethe

J Med Chem· May 2017

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Chemoselective Reduction of α-Cyano Carbonyl Compounds: Application to the Preparation of Heterocycles.
Scott R Pollack, Jeffrey T Kuethe

Org Lett· December 2016

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Discovery of N-[Bis(4-methoxyphenyl)methyl]-4-hydroxy-2-(pyridazin-3-yl)pyrimidine-5-carboxamide (MK-8617), an Orally Active Pan-Inhibitor of Hypoxia-Inducible Factor Prolyl Hydroxylase 1-3 (HIF PHD1-3) for the Treatment of Anemia.
John S Debenham, Christina Madsen-Duggan, Matthew J Clements, Thomas F Walsh, Jeffrey T Kuethe

J Med Chem· December 2016

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Asymmetric Synthesis of a Potent HIV-1 Integrase Inhibitor.
Jeffrey T Kuethe, Guy R Humphrey, Michel Journet, Zhihui Peng, Karla G Childers

J Org Chem· November 2016

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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Jason M Cox, Hong D Chu, Jeffrey T Kuethe, Ying-Duo Gao, Giovanna Scapin

Bioorg Med Chem Lett· June 2016

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Correction to Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell, Jeffrey T Kuethe

J Med Chem· January 2016

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Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Ping Chen, Dennis Feng, Xiaoxia Qian, James Apgar, Robert Wilkening, Jeffrey T Kuethe

Bioorg Med Chem Lett· December 2015

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Discovery of 2-Pyridinone Aminals: A Prodrug Strategy to Advance a Second Generation of HIV-1 Integrase Strand Transfer Inhibitors.
Izzat T Raheem, Abbas M Walji, Daniel Klein, John M Sanders, David A Powell, Jeffrey T Kuethe

J Med Chem· October 2015

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Development of a palladium-catalyzed α-arylation of cyclopropyl nitriles.
Jamie M McCabe Dunn, Jeffrey T Kuethe, Robert K Orr, Matthew Tudge, Louis-Charles Campeau

Org Lett· December 2014

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Discovery of a Potent and Selective DGAT1 Inhibitor with a Piperidinyl-oxy-cyclohexanecarboxylic Acid Moiety.
Shuwen He, Qingmei Hong, Zhong Lai, David X Yang, Pauline C Ting, Jeffrey T Kuethe

ACS Med Chem Lett· October 2014

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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.
Tesfaye Biftu, Ranabir Sinha-Roy, Ping Chen, Xiaoxia Qian, Dennis Feng, Jeffrey T Kuethe

J Med Chem· April 2014

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Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors.
John S Debenham, Thomas H Graham, Andreas Verras, Yong Zhang, Matthew J Clements, Jeffrey T Kuethe

Bioorg Med Chem Lett· December 2013

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Synthesis of stable isotope labeled anacetrapib, its major metabolites and [(14) C]anacetrapib.
Jeffrey T Kuethe, Eric D Soli, Pernilla Royster, Catherine A Quinn

J Labelled Comp Radiopharm· October 2013

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Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172.
Jeffrey Kuethe, Yong-Li Zhong, Nobuyoshi Yasuda, Gregory Beutner, Katherine Linn

Org Lett· August 2013

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Potent DGAT1 Inhibitors in the Benzimidazole Class with a Pyridyl-oxy-cyclohexanecarboxylic Acid Moiety.
Shuwen He, Qingmei Hong, Zhong Lai, Zhicai Wu, Yang Yu, Jeffrey T Kuethe

ACS Med Chem Lett· August 2013

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Synthesis of vaniprevir (MK-7009): lactamization to prepare a 20-membered [corrected] macrocycle.
Zhiguo J Song, David M Tellers, Michel Journet, Jeffrey T Kuethe, David Lieberman

J Org Chem· October 2011

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Magnetically driven agitation in a tube mixer affords clog-resistant fast mixing independent of linear velocity.
Sarah J Dolman, Jason L Nyrop, Jeffrey T Kuethe

J Org Chem· February 2011

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A practical, one-pot synthesis of sulfonylated pyridines.
Kevin M Maloney, Jeffrey T Kuethe, Kathleen Linn

Org Lett· January 2011

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