Publications by authors named "Jens Hukelmann"

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Autologous T cell therapy for PRAME advanced solid tumors in HLA-A*02 patients: a phase 1 trial.
Martin Wermke, Dejka M Araujo, Manik Chatterjee, Apostolia M Tsimberidou, Tobias A W Holderried, Jens Hukelmann

Nat Med· July 2025

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Author Correction: Autologous T cell therapy for PRAME advanced solid tumors in HLA-A*02 patients: a phase 1 trial.
Martin Wermke, Dejka M Araujo, Manik Chatterjee, Apostolia M Tsimberidou, Tobias A W Holderried, Jens Hukelmann

Nat Med· July 2025

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Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development.
Christina J F Courreges, Elizabeth C M Davenport, Benoit Bilanges, Elena Rebollo-Gomez, Jens Hukelmann

Front Immunol· December 2024

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First-in-human dose escalation trial to evaluate the clinical safety and efficacy of an anti-MAGEA1 autologous TCR-transgenic T cell therapy in relapsed and refractory solid tumors.
Martin Wermke, Tobias A W Holderried, Jason John Luke, Van K Morris, Winfried H Alsdorf, Jens Hukelmann

J Immunother Cancer· July 2024

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Proteomic profiling reveals distinct phases to the restoration of chromatin following DNA replication.
Vanesa Alvarez, Susanne Bandau, Hao Jiang, Diana Rios-Szwed, Jens Hukelmann

Cell Rep· January 2023

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Super-killer CTLs are generated by single gene deletion of Bach2.
Philippa R Barton, Alexander J Davenport, Jens Hukelmann, Doreen A Cantrell, Jane C Stinchcombe

Eur J Immunol· November 2022

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Nrf2 activation reprograms macrophage intermediary metabolism and suppresses the type I interferon response.
Dylan G Ryan, Elena V Knatko, Alva M Casey, Jens L Hukelmann, Sharadha Dayalan Naidu

iScience· February 2022

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Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes.
Alejandro J Brenes, Maud Vandereyken, Olivia J James, Harriet Watt, Jens Hukelmann

Elife· September 2021

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Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism.
Emily R Watts, Andrew Jm Howden, Tyler Morrison, Pranvera Sadiku, Jens Hukelmann

J Clin Invest· May 2021

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Erosion of human X chromosome inactivation causes major remodeling of the iPSC proteome.
Alejandro J Brenes, Harunori Yoshikawa, Dalila Bensaddek, Bogdan Mirauta, Daniel Seaton, Jens L Hukelmann

Cell Rep· April 2021

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Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation.
Marcos P Damasio, Julia M Marchingo, Laura Spinelli, Jens L Hukelmann, Doreen A Cantrell

Biochem J· January 2021

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Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation.
Rosalia Fernandez-Alonso, Francisco Bustos, Manon Budzyk, Pankaj Kumar, Andreas O Helbig, Jens Hukelmann

Nat Commun· March 2020

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Quantitative analysis of T cell proteomes and environmental sensors during T cell differentiation.
Andrew J M Howden, Jens L Hukelmann, Alejandro Brenes, Laura Spinelli, Linda V Sinclair

Nat Immunol· November 2019

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Multibatch TMT Reveals False Positives, Batch Effects and Missing Values.
Alejandro Brenes, Jens Hukelmann, Dalila Bensaddek, Angus I Lamond

Mol Cell Proteomics· October 2019

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Antigen receptor control of methionine metabolism in T cells.
Linda V Sinclair, Andrew Jm Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann

Elife· March 2019

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Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice.
Róisín M Loftus, Nadine Assmann, Nidhi Kedia-Mehta, Katie L O'Brien, Arianne Garcia, Jens L Hukelmann

Nat Commun· June 2018

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Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.
Rosalia Fernandez-Alonso, Lindsay Davidson, Jens Hukelmann, Michael Zengerle, Alan R Prescott

EMBO Rep· July 2017

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The cytotoxic T cell proteome and its shaping by the kinase mTOR.
Jens L Hukelmann, Karen E Anderson, Linda V Sinclair, Katarzyna M Grzes, Alejandro Brenes Murillo

Nat Immunol· January 2016

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Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes.
Gavin C Preston, Linda V Sinclair, Aneesa Kaskar, Jens L Hukelmann, Maria N Navarro

EMBO J· August 2015

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Quantitative phosphoproteomics of cytotoxic T cells to reveal protein kinase d 2 regulated networks.
María N Navarro, Juergen Goebel, Jens L Hukelmann, Doreen A Cantrell

Mol Cell Proteomics· December 2014

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PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells.
David K Finlay, Ella Rosenzweig, Linda V Sinclair, Carmen Feijoo-Carnero, Jens L Hukelmann

J Exp Med· December 2012

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