Publications by authors named "Jeremy A Ryan"

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Venetoclax/FluBu2 RIC transplant followed by all-oral venetoclax/decitabine maintenance for poor risk MDS/AML.
Jacqueline S Garcia, Haesook T Kim, H Moses Murdock, Anna Bosch-Vilaseca, Kevin M Panaro, Jeremy Adam Ryan

Blood Adv· December 2025

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Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts.
Elyse A Olesinski, Karanpreet Singh Bhatia, Chuqi Wang, Marissa S Pioso, Xiao Xian Lin, Jeremy A Ryan

Blood Cancer Discov· May 2024

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Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yannan Jia, Alessia Lodi, Jeremy A Ryan

Signal Transduct Target Ther· April 2022

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An CRISPR Screening Platform for Prioritizing Therapeutic Targets in AML.
Shan Lin, Clément Larrue, Nastassja K Scheidegger, Bo Kyung A Seong, Neekesh V Dharia, Jeremy A Ryan

Cancer Discov· February 2022

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Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia.
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yannan Jia, Alessia Lodi, Jeremy A Ryan

Signal Transduct Target Ther· February 2022

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An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities.
Ruth Flümann, Tim Rehkämper, Pascal Nieper, Pauline Pfeiffer, Alessandra Holzem, Jeremy A Ryan

Blood Cancer Discov· January 2021

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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia.
Shruti Bhatt, Marissa S Pioso, Elyse Anne Olesinski, Binyam Yilma, Jeremy A Ryan

Cancer Cell· December 2020

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Targeted inhibition of PI3Kα/δ is synergistic with BCL-2 blockade in genetically defined subtypes of DLBCL.
Kamil Bojarczuk, Kirsty Wienand, Jeremy A Ryan, Linfeng Chen, Mariana Villalobos-Ortiz

Blood· January 2019

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Iterative optimization yields Mcl-1-targeting stapled peptides with selective cytotoxicity to Mcl-1-dependent cancer cells.
Raheleh Rezaei Araghi, Gregory H Bird, Jeremy A Ryan, Justin M Jenson, Marina Godes

Proc Natl Acad Sci U S A· January 2018

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Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
Justin M Jenson, Jeremy A Ryan, Robert A Grant, Anthony Letai, Amy E Keating

Elife· June 2017

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Developmental Regulation of Mitochondrial Apoptosis by c-Myc Governs Age- and Tissue-Specific Sensitivity to Cancer Therapeutics.
Kristopher A Sarosiek, Cameron Fraser, Nathiya Muthalagu, Patrick D Bhola, Weiting Chang, Jeremy A Ryan

Cancer Cell· January 2017

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Functionally identifiable apoptosis-insensitive subpopulations determine chemoresistance in acute myeloid leukemia.
Patrick D Bhola, Brenton G Mar, R Coleman Lindsley, Jeremy A Ryan, Leah J Hogdal

J Clin Invest· October 2016

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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
Elizabeth C Townsend, Mark A Murakami, Alexandra Christodoulou, Amanda L Christie, Johannes Köster, Jeremy A Ryan

Cancer Cell· July 2016

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Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains.
Raheleh Rezaei Araghi, Jeremy A Ryan, Anthony Letai, Amy E Keating

ACS Chem Biol· May 2016

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The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice.
Elizabeth C Townsend, Mark A Murakami, Alexandra Christodoulou, Amanda L Christie, Johannes Köster, Jeremy A Ryan

Cancer Cell· April 2016

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Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.
Shuo-Chieh Wu, Loretta S Li, Nadja Kopp, Joan Montero, Bjoern Chapuy, Jeremy A Ryan

Cancer Cell· July 2015

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Designed BH3 peptides with high affinity and specificity for targeting Mcl-1 in cells.
Glenna Wink Foight, Jeremy A Ryan, Stefano V Gullá, Anthony Letai, Amy E Keating

ACS Chem Biol· September 2014

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High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis.
Julia C Liu, Xiao Guan, Jeremy A Ryan, Ana G Rivera, Caroline Mock

Cell Stem Cell· October 2013

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Pretreatment mitochondrial priming correlates with clinical response to cytotoxic chemotherapy.
Triona Ni Chonghaile, Kristopher A Sarosiek, Thanh-Trang Vo, Jeremy A Ryan, Anupama Tammareddi

Science· November 2011

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Heightened mitochondrial priming is the basis for apoptotic hypersensitivity of CD4+ CD8+ thymocytes.
Jeremy A Ryan, Joslyn K Brunelle, Anthony Letai

Proc Natl Acad Sci U S A· July 2010

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