Publications by authors named "Jerry Adams"

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Mis-expression of GATA6 re-programs cell fate during early hematopoiesis.
Cindy Audiger, Yacine Laâbi, Junli Nie, Leonie Gibson, Julie Wilson-Annan, Jerry M Adams

Cell Rep· May 2024

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Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio, Jerry M Adams

Blood· February 2023

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Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Piers Blombery, Thomas E Lew, Michael A Dengler, Ella R Thompson, Victor S Lin, Jerry M Adams

Blood· February 2022

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BAX mitochondrial integration is regulated allosterically by its α1-α2 loop.
Michael A Dengler, Leonie Gibson, Jerry M Adams

Cell Death Differ· December 2021

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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.
Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno, Jerry M Adams

Cell Death Dis· April 2020

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Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.
Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan, Jerry M Adams

Oncogene· February 2020

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BAX and BAK become killers without a BH3 trigger.
Jerry M Adams

Cell Res· December 2019

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By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737.
Maximilien Tailler, Lisa M Lindqvist, Leonie Gibson, Jerry M Adams

Cell Death Differ· September 2019

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Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity.
Joshi M Ramanjulu, G Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Jerry Adams

Nature· June 2019

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BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.
Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow, Jerry M Adams

Cell Rep· April 2019

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Design of amidobenzimidazole STING receptor agonists with systemic activity.
Joshi M Ramanjulu, G Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Jerry Adams

Nature· December 2018

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The BCL-2 arbiters of apoptosis and their growing role as cancer targets.
Jerry M Adams, Suzanne Cory

Cell Death Differ· January 2018

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Targeting BCL-2-like Proteins to Kill Cancer Cells.
Suzanne Cory, Andrew W Roberts, Peter M Colman, Jerry M Adams

Trends Cancer· August 2016

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Big opportunities for small molecules in immuno-oncology.
Jerry L Adams, James Smothers, Roopa Srinivasan, Axel Hoos

Nat Rev Drug Discov· September 2015

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Donald Metcalf: The father of modern hematology.
Jerry M Adams, Suzanne Cory

Proc Natl Acad Sci U S A· March 2015

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Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.
Dana Westphal, Grant Dewson, Marie Menard, Paul Frederick, Sweta Iyer, Jerry M Adams

Proc Natl Acad Sci U S A· September 2014

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NMR studies of interactions between Bax and BH3 domain-containing peptides in the absence and presence of CHAPS.
Shenggen Yao, Dana Westphal, Jeffrey J Babon, Geoff V Thompson, Adeline Y Robin, Jerry M Adams

Arch Biochem Biophys· March 2014

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Enhanced stability of Mcl1, a prosurvival Bcl2 relative, blunts stress-induced apoptosis, causes male sterility, and promotes tumorigenesis.
Toru Okamoto, Leigh Coultas, Donald Metcalf, Mark F van Delft, Stefan P Glaser, Jerry M Adams

Proc Natl Acad Sci U S A· January 2014

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Metabolism and disposition of oral dabrafenib in cancer patients: proposed participation of aryl nitrogen in carbon-carbon bond cleavage via decarboxylation following enzymatic oxidation.
David A Bershas, Daniele Ouellet, Donna B Mamaril-Fishman, Noelia Nebot, Stanley W Carson, Jerry L Adams

Drug Metab Dispos· December 2013

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Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL.
Brad E Sleebs, Wilhemus J A Kersten, Sanji Kulasegaram, George Nikolakopoulos, Effie Hatzis, Jerry M Adams

J Med Chem· July 2013

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Structure-guided design of a selective BCL-X(L) inhibitor.
Guillaume Lessene, Peter E Czabotar, Brad E Sleebs, Kerry Zobel, Kym N Lowes, Jerry M Adams

Nat Chem Biol· June 2013

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Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.
Peter E Czabotar, Dana Westphal, Grant Dewson, Stephen Ma, Colin Hockings, Jerry M Adams

Cell· January 2013

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Hospital-based coalition to improve regional surge capacity.
Thomas E Terndrup, James M Leaming, R Jerry Adams, Spencer Adoff

West J Emerg Med· November 2012

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Therapeutic potential of a peptide targeting BCL-2 cell guardians in cancer.
Jerry M Adams

J Clin Invest· June 2012

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