Publications by authors named "Jian-kang Jiang"

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Optimization of IRAK1/4/pan-FLT3 kinase inhibitors as treatments for acute myeloid leukemia.
Patrick J Sutter, Morgan M Walker, Chris J Finocchio, Jian-Kang Jiang, Gregory J Tawa

Bioorg Med Chem Lett· December 2025

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Repurposing of lonafarnib as a treatment for SARS-CoV-2 infection.
Mohsin Khan, Parker Irvin, Seung Bum Park, Hannah M Ivester, Inna Ricardo-Lax, Jian-Kang Jiang

JCI Insight· January 2025

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Targeting AML-associated FLT3 mutations with a type I kinase inhibitor.
LaQuita M Jones, Katelyn Melgar, Lyndsey Bolanos, Kathleen Hueneman, Morgan M Walker, Jian-Kang Jiang, Fan Jiang

J Clin Invest· April 2020

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Target Deconvolution of a Multikinase Inhibitor with Antimetastatic Properties Identifies TAOK3 as a Key Contributor to a Cancer Stem Cell-Like Phenotype.
Yansong Bian, Yaroslav Teper, Lesley A Mathews Griner, Taylor J Aiken, Vivek Shukla, Jian-Kang Jiang

Mol Cancer Ther· November 2019

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Overcoming adaptive therapy resistance in AML by targeting immune response pathways.
Katelyn Melgar, Morgan M Walker, LaQuita M Jones, Lyndsey C Bolanos, Kathleen Hueneman, Jian-Kang Jiang

Sci Transl Med· September 2019

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Application of Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP).
Elias C Padilha, Jianyao Wang, Ed Kerns, Arthur Lee, Wenwei Huang, Jian-Kang Jiang

Front Pharmacol· April 2019

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Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors.
Jian-Kang Jiang, Xiuli Huang, Khalida Shamim, Paresma R Patel, Arthur Lee

Bioorg Med Chem Lett· November 2018

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ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells.
Shu Wang, Xiangyun Amy Chen, Jing Hu, Jian-Kang Jiang, Yunfei Li

Mol Cancer Ther· April 2015

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Hydroxylated tropolones inhibit hepatitis B virus replication by blocking viral ribonuclease H activity.
Gaofeng Lu, Elena Lomonosova, Xiaohong Cheng, Eileen A Moran, Marvin J Meyers, Jian-kang Jiang

Antimicrob Agents Chemother· February 2015

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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages.
Eva M Palsson-McDermott, Anne M Curtis, Gautam Goel, Mario A R Lauterbach, Frederick J Sheedy, Jian-Kang Jiang

Cell Metab· February 2015

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Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages.
Eva M Palsson-McDermott, Anne M Curtis, Gautam Goel, Mario A R Lauterbach, Frederick J Sheedy, Jian-Kang Jiang

Cell Metab· January 2015

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RUC-4: a novel αIIbβ3 antagonist for prehospital therapy of myocardial infarction.
Jihong Li, Spandana Vootukuri, Yi Shang, Ana Negri, Jian-Kang Jiang

Arterioscler Thromb Vasc Biol· October 2014

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Multiple A2E treatments lead to melanization of rod outer segment-challenged ARPE-19 cells.
Eugenia Poliakov, Natalya V Strunnikova, Jian-kang Jiang, Bianca Martinez, Toral Parikh

Mol Vis· September 2014

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A novel class of ion displacement ligands as antagonists of the αIIbβ3 receptor that limit conformational reorganization of the receptor.
Jian-kang Jiang, Joshua G McCoy, Min Shen, Christopher A LeClair, Wenwei Huang

Bioorg Med Chem Lett· February 2014

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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
Lesley A Mathews Griner, Rajarshi Guha, Paul Shinn, Ryan M Young, Jonathan M Keller, Jian-Kang Jiang

Proc Natl Acad Sci U S A· February 2014

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CD28 and ITK signals regulate autoreactive T cell trafficking.
Nitya Jain, Bing Miu, Jian-kang Jiang, Kai K McKinstry, Amanda Prince

Nat Med· December 2013

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Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK-mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma.
Scott R P McDonnell, Steven R Hwang, Delphine Rolland, Carlos Murga-Zamalloa, Venkatesha Basrur, Jian-Kang Jiang

Blood· August 2013

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis.
Dimitrios Anastasiou, Yimin Yu, William J Israelsen, Jian-Kang Jiang, Matthew B Boxer

Nat Chem Biol· October 2012

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TCR signaling via Tec kinase ITK and interferon regulatory factor 4 (IRF4) regulates CD8+ T-cell differentiation.
Ribhu Nayar, Megan Enos, Amanda Prince, Hyunmu Shin, Saskia Hemmers, Jian-kang Jiang

Proc Natl Acad Sci U S A· October 2012

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses.
Dimitrios Anastasiou, George Poulogiannis, John M Asara, Matthew B Boxer, Jian-kang Jiang

Science· December 2011

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Chiral kinase inhibitors.
Jian-kang Jiang, Min Shen, Craig J Thomas, Mathew B Boxer

Curr Top Med Chem· August 2011

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Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.
Suhman Chung, Daniel M Himmel, Jian-Kang Jiang, Krzysztof Wojtak, Joseph D Bauman

J Med Chem· July 2011

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CP-690,550, a therapeutic agent, inhibits cytokine-mediated Jak3 activation and proliferation of T cells from patients with ATL and HAM/TSP.
Wei Ju, Meili Zhang, Jian-kang Jiang, Craig J Thomas, Unsong Oh

Blood· February 2011

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