Publications by authors named "Matthew B Boxer"

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SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells.
Ke Kong, Wei Zhao, Jonathan H Shrimp, Marius Vava, Rohan Sinha, Matthew B Boxer

J Med Chem· September 2025

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12-Lipoxygenase Inhibition Improves Glycemia and Obesity-associated Inflammation in Male Human Gene Replacement Mice.
Kerim B Kaylan, Titli Nargis, Kayla Figatner, Jiayi E Wang, Sarida Pratuangtham, Matthew B Boxer

Endocrinology· April 2025

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12-Lipoxygenase inhibition improves glucose homeostasis and obesity-associated inflammation in human gene replacement mice.
Kerim B Kaylan, Titli Nargis, Kayla Figatner, Jiayi E Wang, Sarida Pratuangtham, Matthew B Boxer

bioRxiv· January 2025

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12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice.
Titli Nargis, Charanya Muralidharan, Jacob R Enriquez, Jiayi E Wang, Kerim B Kaylan, Matthew B Boxer

JCI Insight· December 2024

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12-Lipoxygenase inhibition delays onset of autoimmune diabetes in human gene replacement mice.
Titli Nargis, Charanya Muralidharan, Jacob R Enriquez, Jiayi E Wang, Kerim Kaylan, Matthew B Boxer

bioRxiv· October 2024

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A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion.
Satoshi Kofuji, Kara Wolfe, Kazutaka Sumita, Shun Kageyama, Hirofumi Yoshino, Matthew B Boxer

Biochem Biophys Res Commun· July 2024

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Novel Strategy to Combat the Procoagulant Phenotype in Heparin-Induced Thrombocytopenia Using 12-LOX Inhibition.
Stephanie A Renna, Xuefei Zhao, Satya P Kunapuli, Peisong Ma, Michael Holinstat, Matthew B Boxer

Arterioscler Thromb Vasc Biol· October 2023

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Multimodal action of KRP203 on phosphoinositide kinases in vitro and in cells.
Yoshiki Ikeda, Mindy I Davis, Kazutaka Sumita, Yuxiang Zheng, Satoshi Kofuji, Matthew B Boxer

Biochem Biophys Res Commun· October 2023

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SULT1A1-dependent sulfonation of alkylators is a lineage-dependent vulnerability of liver cancers.
Lei Shi, William Shen, Mindy I Davis, Ke Kong, Phuong Vu, Matthew B Boxer

Nat Cancer· March 2023

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The HIV protease inhibitor, ritonavir, corrects diverse brain phenotypes across development in mouse model of DYT-TOR1A dystonia.
Zachary F Caffall, Bradley J Wilkes, Ricardo Hernández-Martinez, Joseph E Rittiner, Jennifer T Fox, Matthew B Boxer

Sci Transl Med· August 2021

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Discovery and Optimization of 2-1λ-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
Jason M Rohde, Surendra Karavadhi, Rajan Pragani, Li Liu, Yuhong Fang, Matthew B Boxer

J Med Chem· April 2021

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EWS-FLI1-regulated Serine Synthesis and Exogenous Serine are Necessary for Ewing Sarcoma Cellular Proliferation and Tumor Growth.
Sameer H Issaq, Arnulfo Mendoza, Ria Kidner, Tracy I Rosales, Damien Y Duveau, Matthew B Boxer

Mol Cancer Ther· July 2020

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Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
Theresa D Manz, Sindhu C Sivakumaren, Adam Yasgar, Matthew D Hall, Mindy I Davis, Matthew B Boxer

ACS Med Chem Lett· March 2020

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High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma.
Sarah Wang, Elizabeth E Hwang, Rajarshi Guha, Allison F O'Neill, Nicole Melong, Matthew B Boxer

Clin Cancer Res· July 2019

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Discovery of novel inhibitors of human galactokinase by virtual screening.
Xin Hu, Ya-Qin Zhang, Olivia W Lee, Li Liu, Manshu Tang, Matthew B Boxer

J Comput Aided Mol Des· April 2019

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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
Sara E Kearney, Gergely Zahoránszky-Kőhalmi, Kyle R Brimacombe, Mark J Henderson, Caitlin Lynch, Matthew B Boxer

ACS Cent Sci· December 2018

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Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Jason M Rohde, Kyle R Brimacombe, Li Liu, Michael E Pacold, Adam Yasgar, Matthew B Boxer

Bioorg Med Chem· May 2018

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A Comprehensive Patient-Derived Xenograft Collection Representing the Heterogeneity of Melanoma.
Clemens Krepler, Katrin Sproesser, Patricia Brafford, Marilda Beqiri, Bradley Garman, Matthew B Boxer

Cell Rep· November 2017

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Assessing inhibitors of mutant isocitrate dehydrogenase using a suite of pre-clinical discovery assays.
Daniel J Urban, Natalia J Martinez, Mindy I Davis, Kyle R Brimacombe, Dorian M Cheff, Matthew B Boxer

Sci Rep· October 2017

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PKM2 activation sensitizes cancer cells to growth inhibition by 2-deoxy-D-glucose.
Sui Seng Tee, Jae Mo Park, Ralph E Hurd, Kyle R Brimacombe, Matthew B Boxer

Oncotarget· October 2017

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Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models.
Mindy I Davis, Rajan Pragani, Jennifer T Fox, Min Shen, Kalindi Parmar, Matthew B Boxer

J Biol Chem· November 2016

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Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors.
Anju Singh, Sreedhar Venkannagari, Kyu H Oh, Ya-Qin Zhang, Jason M Rohde, Matthew B Boxer

ACS Chem Biol· November 2016

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Corrigendum: A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect.
Paula Lopez-Serra, Miguel Marcilla, Alberto Villanueva, Antonio Ramos-Fernandez, Anna Palau, Matthew B Boxer

Nat Commun· November 2016

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Identification of Novel Plasmodium falciparum Hexokinase Inhibitors with Antiparasitic Activity.
Mindy I Davis, Stephen L Patrick, Walker M Blanding, Varun Dwivedi, Jimmy Suryadi, Matthew B Boxer

Antimicrob Agents Chemother· October 2016

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Caspase-1 causes truncation and aggregation of the Parkinson's disease-associated protein α-synuclein.
Wei Wang, Linh T T Nguyen, Christopher Burlak, Fariba Chegini, Feng Guo, Matthew B Boxer

Proc Natl Acad Sci U S A· August 2016

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