Publications by authors named "John Catlow"

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Expansion of Knowledge on OCT1 Variant Activity and Using Oct1/2 Mice.
Bridget L Morse, Lisa Hong Chen, John T Catlow, John K Fallon, Philip C Smith

Front Pharmacol· February 2021

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Modulation of TARP 8-Containing AMPA Receptors as a Novel Therapeutic Approach for Chronic Pain.
Kelly L Knopp, Rosa Maria A Simmons, Wenhong Guo, Benjamin L Adams, Kevin M Gardinier, John Catlow

J Pharmacol Exp Ther· June 2019

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Targeted Blockade of TARP-γ8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611).
Jeffrey M Witkin, Douglas A Schober, Scott D Gleason, John T Catlow, Warren J Porter

CNS Neurol Disord Drug Targets· March 2019

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Further Evaluation of Mechanisms Associated with the Antidepressantlike Signature of Scopolamine in Mice.
Anna E Martin, Douglas A Schober, Alexander Nikolayev, Vladimir V Tolstikov, Wesley H Anderson, John T Catlow

CNS Neurol Disord Drug Targets· April 2018

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Synthesis and Pharmacological Characterization of C4-Amide-Substituted 2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1 S,2 S,4 S,5 R,6 S)-2-Amino-4-[(3-methoxybenzoyl)amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2794193), a Highly Potent and Selective mGlu Receptor Agonist.
James A Monn, Steven S Henry, Steven M Massey, David K Clawson, Qi Chen, John T Catlow

J Med Chem· March 2018

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In vitro pharmacological and rat pharmacokinetic characterization of LY3020371, a potent and selective mGlu receptor antagonist.
Jeffrey M Witkin, Paul L Ornstein, Charles H Mitch, Renhua Li, Stephon C Smith, John Catlow

Neuropharmacology· March 2017

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Discovery of dual positive allosteric modulators (PAMs) of the metabotropic glutamate 2 receptor and CysLT1 antagonists for treating migraine headache.
Maria-Jesus Blanco, Dana R Benesh, James A Knobelsdorf, Albert Khilevich, Guillermo S Cortez, John Catlow

Bioorg Med Chem Lett· January 2017

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Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism.
Akihiko S Kato, Kevin D Burris, Kevin M Gardinier, Douglas L Gernert, Warren J Porter, John T Catlow

Nat Med· December 2016

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Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression.
Bruce A Dressman, Eric G Tromiczak, Mark D Chappell, Allie E Tripp, Steven J Quimby, John T Catlow

Bioorg Med Chem Lett· December 2016

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Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371·HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
Mark D Chappell, Renhua Li, Stephon C Smith, Bruce A Dressman, Eric G Tromiczak, John T Catlow

J Med Chem· December 2016

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Preclinical findings predicting efficacy and side-effect profile of LY2940094, an antagonist of nociceptin receptors.
Jeffrey M Witkin, Linda M Rorick-Kehn, Mark J Benvenga, Benjamin L Adams, Scott D Gleason, John T Catlow

Pharmacol Res Perspect· December 2016

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Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.
James A Monn, Lourdes Prieto, Lorena Taboada, Junliang Hao, Matthew R Reinhard, John T Catlow

J Med Chem· September 2015

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Synthesis and pharmacological characterization of C4-disubstituted analogs of 1S,2S,5R,6S-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate: identification of a potent, selective metabotropic glutamate receptor agonist and determination of agonist-bound human mGlu2 and mGlu3 amino terminal domain structures.
James A Monn, Lourdes Prieto, Lorena Taboada, Concepcion Pedregal, Junliang Hao, John T Catlow

J Med Chem· February 2015

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Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin.
Jeffrey M Witkin, Susan Leucke, Linda K Thompson, Renee A Lynch, Chunjin Ding, John T Catlow

CNS Neurol Disord Drug Targets· June 2013

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Synthesis and pharmacological characterization of 4-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates: identification of new potent and selective metabotropic glutamate 2/3 receptor agonists.
James A Monn, Matthew J Valli, Steven M Massey, Junliang Hao, Matthew R Reinhard, John T Catlow

J Med Chem· June 2013

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Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.
Junliang Hao, Veronique Dehlinger, Adam M Fivush, Helene C E Rudyk, Thomas C Britton, John T Catlow

Bioorg Med Chem Lett· March 2013

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N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link between behavioral and central nervous system neurochemical changes.
Matthew J Fell, Jeffrey M Witkin, Julie F Falcone, Jason S Katner, Kenneth W Perry, John T Catlow

J Pharmacol Exp Ther· January 2011

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The 5-hydroxytryptamine2A receptor antagonist R-(+)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl-4-piperidinemethanol (M100907) attenuates impulsivity after both drug-induced disruption (dizocilpine) and enhancement (antidepressant drugs) of differential-reinforcement-of-low-rate 72-s behavior in the rat.
Paul A Ardayfio, Mark J Benvenga, Stephen F Chaney, Patrick L Love, John Catlow

J Pharmacol Exp Ther· December 2008

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Pharmacological and pharmacokinetic properties of a structurally novel, potent, and selective metabotropic glutamate 2/3 receptor agonist: in vitro characterization of agonist (-)-(1R,4S,5S,6S)-4-amino-2-sulfonylbicyclo[3.1.0]-hexane-4,6-dicarboxylic acid (LY404039).
Linda M Rorick-Kehn, Bryan G Johnson, Jennifer L Burkey, Rebecca A Wright, David O Calligaro, John T Catlow

J Pharmacol Exp Ther· April 2007

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Synthesis and metabotropic glutamate receptor activity of S-oxidized variants of (-)-4-amino-2-thiabicyclo-[3.1.0]hexane-4,6-dicarboxylate: identification of potent, selective, and orally bioavailable agonists for mGlu2/3 receptors.
James A Monn, Steven M Massey, Matthew J Valli, Steven S Henry, Gregory A Stephenson, John Catlow

J Med Chem· January 2007

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Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist.
Ana Belén Bueno, Iván Collado, Alfonso de Dios, Carmen Domínguez, José Alfredo Martín, John Catlow

J Med Chem· August 2005

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