Publications by authors named "John F Reilly"

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Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates.
Aislinn Mayfield, Xin Zhang, Ivan Efremov, Michael G Kauffman, John F Reilly

SLAS Discov· April 2025

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Drug Discovery for Diseases with High Unmet Need Through Perturbation of Biomolecular Condensates.
Bahareh Eftekharzadeh, Aislinn Mayfield, Michael G Kauffman, John F Reilly

J Mol Biol· December 2024

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Phase Separation in Biology and Disease; Current Perspectives and Open Questions.
Steven Boeynaems, Shasha Chong, Jörg Gsponer, Liam Holt, Dragomir Milovanovic, John F Reilly

J Mol Biol· March 2023

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Transplanted organoids empower human preclinical assessment of drug candidate for the clinic.
Amy D Westerling-Bui, Eva Maria Fast, Thomas W Soare, Srinivasan Venkatachalan, Michael DeRan, John F Reilly

Sci Adv· July 2022

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Safety and Efficacy of GFB-887, a TRPC5 Channel Inhibitor, in Patients With Focal Segmental Glomerulosclerosis, Treatment-Resistant Minimal Change Disease, or Diabetic Nephropathy: TRACTION-2 Trial Design.
Liron Walsh, John F Reilly, Caitlin Cornwall, Gregory A Gaich, Debbie S Gipson

Kidney Int Rep· October 2021

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Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model.
Maolin Yu, Mark W Ledeboer, Matthew Daniels, Goran Malojcic, Thomas T Tibbitts, John F Reilly

ACS Med Chem Lett· November 2019

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Activity of dalotuzumab, a selective anti-IGF1R antibody, in combination with erlotinib in unselected patients with Non-small-cell lung cancer: a phase I/II randomized trial.
Teresa Moran, Enriqueta Felip, Vicki Keedy, Hossein Borghaei, Frances A Shepherd, John F Reilly

Exp Hematol Oncol· November 2014

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Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
Alan B Northrup, Matthew H Katcher, Michael D Altman, Melissa Chenard, Matthew H Daniels, John F Reilly

J Med Chem· March 2013

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Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
Jason D Katz, James P Jewell, David J Guerin, Jongwon Lim, Christopher J Dinsmore, John F Reilly

J Med Chem· June 2011

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Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.
Clay L Efferson, Christopher T Winkelmann, Christopher Ware, Timothy Sullivan, Saverio Giampaoli, John F Reilly

Cancer Res· March 2010

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MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Bo-Sheng Pan, Grace K Y Chan, Melissa Chenard, An Chi, Lenora J Davis, John F Reilly

Cancer Res· February 2010

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De novo discovery of a gamma-secretase inhibitor response signature using a novel in vivo breast tumor model.
James W Watters, Chun Cheng, Pradip K Majumder, Ruojie Wang, Sireesha Yalavarthi, John F Reilly

Cancer Res· December 2009

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Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks.
Diane Palmieri, Paul R Lockman, Fancy C Thomas, Emily Hua, Jeanne Herring, John F Reilly

Clin Cancer Res· October 2009

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Inhibition of tumor growth progression by antiandrogens and mTOR inhibitor in a Pten-deficient mouse model of prostate cancer.
Weisheng Zhang, Joe Zhu, Clay L Efferson, Chris Ware, Jennifer Tammam, John F Reilly

Cancer Res· September 2009

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Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study.
Evanthia Galanis, Kurt A Jaeckle, Matthew J Maurer, Joel M Reid, Matthew M Ames, John F Reilly

J Clin Oncol· April 2009

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A quantitative volumetric micro-computed tomography method to analyze lung tumors in genetically engineered mouse models.
Brian B Haines, Kimberly A Bettano, Melissa Chenard, Raquel S Sevilla, Christopher Ware, John F Reilly

Neoplasia· January 2009

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Constitutive activation of signal transducers and activators of transcription predicts vorinostat resistance in cutaneous T-cell lymphoma.
Valeria R Fantin, Andrey Loboda, Cloud P Paweletz, Ronald C Hendrickson, Jacqueline W Pierce, John F Reilly

Cancer Res· May 2008

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Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes.
Guillermo Garcia-Manero, Hui Yang, Carlos Bueso-Ramos, Alessandra Ferrajoli, Jorge Cortes, John F Reilly

Blood· February 2008

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Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).
Madeleine Duvic, Rakshandra Talpur, Xiao Ni, Chunlei Zhang, Parul Hazarika, John F Reilly

Blood· January 2007

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Adult mouse brain gene expression patterns bear an embryologic imprint.
Matthew A Zapala, Iiris Hovatta, Julie A Ellison, Lisa Wodicka, Jo A Del Rio, John F Reilly

Proc Natl Acad Sci U S A· July 2005

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Mouse models of human neurodegenerative disorders: requirements for medication development.
Floyd E Bloom, John F Reilly, Jeff M Redwine, Chi-Cheng Wu, Warren G Young

Arch Neurol· February 2005

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Ligand dependent and independent internalization and nuclear translocation of fibroblast growth factor (FGF) receptor 1.
John F Reilly, Eiichi Mizukoshi, Pamela A Maher

DNA Cell Biol· September 2004

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High-throughput morphometric analysis of individual neurons.
Chi-Cheng Wu, John F Reilly, Warren G Young, John H Morrison, Floyd E Bloom

Cereb Cortex· May 2004

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Amyloid deposition in the hippocampus and entorhinal cortex: quantitative analysis of a transgenic mouse model.
John F Reilly, Dora Games, Russell E Rydel, Stephen Freedman, Dale Schenk

Proc Natl Acad Sci U S A· April 2003

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Dentate gyrus volume is reduced before onset of plaque formation in PDAPP mice: a magnetic resonance microscopy and stereologic analysis.
Jeffrey M Redwine, Barry Kosofsky, Russell E Jacobs, Dora Games, John F Reilly

Proc Natl Acad Sci U S A· February 2003

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