Publications by authors named "John Mehl"

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2023 White Paper on Recent Issues in Bioanalysis: Deuterated Drugs; LNP; Tumor/FFPE Biopsy; Targeted Proteomics; Small Molecule Covalent Inhibitors; Chiral Bioanalysis; Remote Regulatory Assessments; Sample Reconciliation/Chain of Custody - Recommendations on Mass Spectrometry, Chromatography, Sample Preparation Latest Developments, Challenges, and Solutions and BMV/Regulated Bioanalysis - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/IVD/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Mike Baratta, Wenying Jian, Shawna Hengel, Surinder Kaur, Jennifer Cunliffe, John Mehl

Bioanalysis· June 2024

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Protein LC-MS Tools for the Next Generation of Biotherapeutic Analyses from Preclinical and Clinical Serum.
Nicole A Schneck, John T Mehl, John F Kellie

J Am Soc Mass Spectrom· September 2023

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2022 White Paper on Recent Issues in Bioanalysis: ICH M10 BMV Guideline & Global Harmonization; Hybrid Assays; Oligonucleotides & ADC; Non-Liquid & Rare Matrices; Regulatory Inputs ( - Recommendations on Mass Spectrometry, Chromatography and Sample Preparation, Novel Technologies, Novel Modalities, and Novel Challenges, ICH M10 BMV Guideline & Global Harmonization - Regulatory Agencies' Inputs on Regulated Bioanalysis/BMV, Biomarkers/CDx/BAV, Immunogenicity, Gene & Cell Therapy and Vaccine).
Matt Szapacs, Wenying Jian, Daniel Spellman, Jennifer Cunliffe, Elizabeth Verburg, John Mehl

Bioanalysis· August 2023

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Top-Down Characterization and Intact Mass Quantitation of a Monoclonal Antibody Drug from Serum by Use of a Quadrupole TOF MS System Equipped with Electron-Activated Dissociation.
John F Kellie, Nicole A Schneck, Jason C Causon, Takashi Baba, John T Mehl

J Am Soc Mass Spectrom· January 2023

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Highly Accurate and Robust Absolute Quantification of Target Proteins in Formalin-Fixed Paraffin-Embedded (FFPE) Tissues by LC-MS.
Jie Pu, Chao Xue, Shihan Huo, Qingqing Shen, Yang Qu, John T Mehl

Anal Chem· January 2023

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An antibody-free platform for multiplexed, sensitive quantification of protein biomarkers in complex biomatrices.
Bo An, Timothy W Sikorski, John F Kellie, Zhuo Chen, Nicole A Schneck, John Mehl

J Chromatogr A· August 2022

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Target-Mediated Drug Disposition Affects the Pharmacokinetics of Interleukin-10 Fragment Crystallizable Fusion Proteins at Pharmacologically Active Doses.
Zheng Yang, Surendran Rajendran, Vanessa Spires, Brian Poirson, Murali Gururajan, John Mehl

Drug Metab Dispos· July 2022

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Application of Pharmacokinetic/Pharmacodynamic Modeling to Bridge Mouse Antitumor Efficacy and Monkey Toxicology Data for Determining the Therapeutic Index of an Interleukin-10 Fc Fusion Protein.
Zheng Yang, James Loy, Brian Poirson, Yanshan Dai, Surendran Rajendran, John Mehl

Front Pharmacol· June 2022

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2021 White Paper on Recent Issues in Bioanalysis: Mass Spec of Proteins, Extracellular Vesicles, CRISPR, Chiral Assays, Oligos; Nanomedicines Bioanalysis; ICH M10 Section 7.1; Non-Liquid & Rare Matrices; Regulatory Inputs ( - Recommendations on Endogenous Compounds, Small Molecules, Complex Methods, Regulated Mass Spec of Large Molecules, Small Molecule, PoC &  - Regulatory Agencies' Inputs on Bioanalysis, Biomarkers, Immunogenicity, Gene & Cell Therapy and Vaccine).
Surinder Kaur, Stephen C Alley, Matt Szapacs, Amanda Wilson, Eugene Ciccimaro, John Mehl

Bioanalysis· May 2022

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Intact Protein Mass Spectrometry for Therapeutic Protein Quantitation, Pharmacokinetics, and Biotransformation in Preclinical and Clinical Studies: An Industry Perspective.
John F Kellie, John C Tran, Wenying Jian, Barry Jones, John T Mehl

J Am Soc Mass Spectrom· August 2021

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Quantification of surrogate monoclonal antibodies in mouse serum using LC-MS/MS.
John T Mehl, France Landry, Lorell Discenza, Bogdan Sleczka, Qihong Zhao

Bioanalysis· February 2021

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Fucosyl monosialoganglioside: Quantitative analysis of specific potential biomarkers of lung cancer in biological matrices using immunocapture extraction/tandem mass spectrometry.
Asoka Ranasinghe, John Mehl, Celia D'Arienzo, Fizal Nabbie, Christopher Chiu

Rapid Commun Mass Spectrom· September 2018

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LC-MS Differential Analysis for Fast and Sensitive Determination of Biotransformation of Therapeutic Proteins.
Ming Yao, Bingming Chen, Weiping Zhao, John T Mehl, Lingjun Li

Drug Metab Dispos· April 2018

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Slow Off-Rate Modified Aptamer (SOMAmer) as a Novel Reagent in Immunoassay Development for Accurate Soluble Glypican-3 Quantification in Clinical Samples.
Jia Duo, Camelia Chiriac, Richard Y-C Huang, John Mehl, Guodong Chen

Anal Chem· April 2018

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2017 White Paper on recent issues in bioanalysis: aren't BMV guidance/guidelines 'Scientific'? (Part 1 - LCMS: small molecules, peptides and small molecule biomarkers).
Jan Welink, Eric Yang, Nicola Hughes, Brian Rago, Eric Woolf, John Mehl

Bioanalysis· November 2017

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Affinity extraction LC-MS for small-molecule drug quantification: considerations, challenges and potential applications.
John T Mehl

Bioanalysis· June 2017

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Quantification of in vivo site-specific Asp isomerization and Asn deamidation of mAbs in animal serum using IP-LC-MS.
John T Mehl, Bogdan G Sleczka, Eugene F Ciccimaro, Alexander T Kozhich, Deb G Gilbertson

Bioanalysis· August 2016

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Improving the immunogenicity of a trivalent Neisseria meningitidis native outer membrane vesicle vaccine by genetic modification.
Lan Zhang, Zhiyun Wen, Jing Lin, Hui Xu, Paul Herbert, John T Mehl

Vaccine· July 2016

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Label-free quantitative mass spectrometry for analysis of protein antigens in a meningococcal group B outer membrane vesicle vaccine.
Lawrence W Dick, John T Mehl, John W Loughney, Anna Mach, Richard R Rustandi

Hum Vaccin Immunother· March 2016

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Ultrasensitive quantitative LC-MS/MS of an inhibitor of apoptosis protein's antagonist in plasma using protein target affinity extraction.
Lorell N Discenza, Georgia Cornelius, Jinping Gan, Nicolas Szapiel, Randy L Talbott, John T Mehl

Bioanalysis· February 2016

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Quantification of human mAbs in mouse tissues using generic affinity enrichment procedures and LC-MS detection.
Bogdan G Sleczka, John T Mehl, David J Shuster, Katherine E Lewis, Robin Moore

Bioanalysis· July 2015

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Application and challenges in using LC-MS assays for absolute quantitative analysis of therapeutic proteins in drug discovery.
Joanna Zheng, John Mehl, Yongxin Zhu, Baomin Xin, Timothy Olah

Bioanalysis· March 2014

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Immunoaffinity purification using anti-PEG antibody followed by two-dimensional liquid chromatography/tandem mass spectrometry for the quantification of a PEGylated therapeutic peptide in human plasma.
Yang Xu, John T Mehl, Ray Bakhtiar, Eric J Woolf

Anal Chem· August 2010

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Blockers of the delayed-rectifier potassium current in pancreatic beta-cells enhance glucose-dependent insulin secretion.
James Herrington, Yun-Ping Zhou, Randal M Bugianesi, Paula M Dulski, Yue Feng, John T Mehl

Diabetes· April 2006

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Automated protein identification using atmospheric-pressure matrix-assisted laser desorption/ionization.
John T Mehl, John J Cummings, Ellen Rohde, Nathan N Yates

Rapid Commun Mass Spectrom· August 2003

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