Publications by authors named "John P Mathias"

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Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1.
Agustin Casimiro-Garcia, Christophe Allais, Agnes Brennan, Chulho Choi, Gabriela Dower, John P Mathias

J Med Chem· January 2022

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Discovery of Clinical Candidate 1-{[(2S,3S,4S)-3-Ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide (PF-06650833), a Potent, Selective Inhibitor of Interleukin-1 Receptor Associated Kinase 4 (IRAK4), by Fragment-Based Drug Design.
Katherine L Lee, Catherine M Ambler, David R Anderson, Brian P Boscoe, Andrea G Bree, John P Mathias

J Med Chem· July 2017

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Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Seungil Han, Robert M Czerwinski, Nicole L Caspers, David C Limburg, WeiDong Ding, John P Mathias

Biochem J· June 2014

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Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.
David S Millan, Mark E Bunnage, Jane L Burrows, Kenneth J Butcher, Peter G Dodd, John P Mathias

J Med Chem· November 2011

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Fragment based discovery of a novel and selective PI3 kinase inhibitor.
Samantha J Hughes, David S Millan, Iain C Kilty, Russell A Lewthwaite, John P Mathias

Bioorg Med Chem Lett· November 2011

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Highly potent and selective chiral inhibitors of PDE5: an illustration of Pfeiffer's rule.
Mark E Bunnage, John P Mathias, Anthony Wood, Duncan Miller, Stephen D A Street

Bioorg Med Chem Lett· December 2008

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Origins of Enantioselectivity with Nitrogen-Sulfur Chelate Ligands in Palladium-Catalyzed Allylic Substitution.
Harry Adams, James C. Anderson, Rachel Cubbon, Daniel S. James, John P. Mathias

J Org Chem· October 1999

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