Publications by authors named "Jon Jacobsen"

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Characterization of the dual ITK/JAK3 small molecule covalent inhibitor ATI-2138.
Aparna Kaul, Heidi Hope, Canxin Xu, Rakesh Basavalingappa, Sara K Binz, E Jon Jacobsen

J Pharmacol Exp Ther· February 2025

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ATI-1777, a Topical Jak1/3 Inhibitor, May Benefit Atopic Dermatitis without Systemic Drug Exposure: Results from Preclinical Development and Phase 2a Randomized Control Study ATI-1777-AD-201.
Paul Changelian, Canxin Xu, Steve Mnich, Heidi Hope, Kourtney Kostecki, Jon Jacobsen

JID Innov· March 2024

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Positive allosteric modulators of the α7 nicotinic acetylcholine receptor: SAR investigation around PNU-120596.
Brad A Acker, Valentina O Badescu, Mitchell B Berkenpas, Vincent E Groppi, Mihaly Hajós, E Jon Jacobsen

Bioorg Med Chem Lett· September 2023

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Incremental Density-Based Clustering on Multicore Processors.
Son T Mai, Jon Jacobsen, Sihem Amer-Yahia, Ivor Spence, Nhat-Phuong Tran

IEEE Trans Pattern Anal Mach Intell· March 2022

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Substrate-based kinase activity inference identifies MK2 as driver of colitis.
Samantha Dale Strasser, Phaedra C Ghazi, Alina Starchenko, Myriam Boukhali, Amanda Edwards, Jon Jacobsen

Integr Biol (Camb)· November 2019

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Selective inhibition of the p38α MAPK-MK2 axis inhibits inflammatory cues including inflammasome priming signals.
Chun Wang, Susan Hockerman, E Jon Jacobsen, Yael Alippe, Shaun R Selness

J Exp Med· May 2018

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Diabetic and non-diabetic patients report equal symptom relief after arthroscopic capsular release of frozen shoulder.
Johanne M Lyhne, Jon R Jacobsen, Søren J Hansen, Carsten M Jensen, Søren R Deutch

J Clin Orthop Trauma· May 2018

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Acromioplasty in patients selected for operation by national guidelines.
Jón Rói Jacobsen, Carsten M Jensen, Søren R Deutch

J Shoulder Elbow Surg· October 2017

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Integrodifference models for persistence in temporally varying river environments.
Jon Jacobsen, Yu Jin, Mark A Lewis

J Math Biol· February 2015

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Evaluation of aminohydantoins as a novel class of antimalarial agents.
Marvin J Meyers, Micky D Tortorella, Jing Xu, Limei Qin, Zhengxiang He, E Jon Jacobsen

ACS Med Chem Lett· January 2014

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The hepatitis B virus ribonuclease H is sensitive to inhibitors of the human immunodeficiency virus ribonuclease H and integrase enzymes.
John E Tavis, Xiaohong Cheng, Yuan Hu, Michael Totten, Feng Cao, E Jon Jacobsen

PLoS Pathog· January 2013

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The addition of lidocaine to bupivacaine does not shorten the duration of spinal anesthesia: a randomized, double-blinded study of patients undergoing knee arthroscopy.
Jon Jacobsen, Bent Husum, Henrik von Staffeldt, Thorkild F Qvist, Peer Eske Jensen

Anesth Analg· November 2011

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Investigation of the pyrazinones as PDE5 inhibitors: evaluation of regioisomeric projections into the solvent region.
Robert O Hughes, Todd Maddux, D Joseph Rogier, Sharon Lu, John K Walker, E Jon Jacobsen

Bioorg Med Chem Lett· November 2011

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Design, synthesis, and biological evaluation of 3-[4-(2-hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a potent, orally active, brain penetrant inhibitor of phosphodiesterase 5 (PDE5).
Robert O Hughes, D Joseph Rogier, E Jon Jacobsen, John K Walker, Alan Macinnes

J Med Chem· March 2010

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Optimization of the aminopyridopyrazinones class of PDE5 inhibitors: discovery of 3-[(trans-4-hydroxycyclohexyl)amino]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one.
Robert O Hughes, John K Walker, D Joseph Rogier, Steve E Heasley, Rhadika M Blevis-Bal, E Jon Jacobsen

Bioorg Med Chem Lett· September 2009

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Investigation of aminopyridiopyrazinones as PDE5 inhibitors: Evaluation of modifications to the central ring system.
Robert O Hughes, John K Walker, Jerry W Cubbage, Yvette M Fobian, D Joseph Rogier, E Jon Jacobsen

Bioorg Med Chem Lett· August 2009

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Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors.
Dafydd R Owen, John K Walker, E Jon Jacobsen, John N Freskos, Robert O Hughes

Bioorg Med Chem Lett· August 2009

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Discovery of N-[(3R,5R)-1-azabicyclo[3.2.1]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide as an agonist of the alpha7 nicotinic acetylcholine receptor: in vitro and in vivo activity.
Brad A Acker, E Jon Jacobsen, Bruce N Rogers, Donn G Wishka, Steven C Reitz

Bioorg Med Chem Lett· June 2008

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Design, synthesis, structure-activity relationship, and in vivo activity of azabicyclic aryl amides as alpha7 nicotinic acetylcholine receptor agonists.
Daniel P Walker, Donn G Wishka, David W Piotrowski, Shaojuan Jia, Steven C Reitz, E Jon Jacobsen

Bioorg Med Chem· December 2006

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Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an agonist of the alpha7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: synthesis and structure--activity relationship.
Donn G Wishka, Daniel P Walker, Karen M Yates, Steven C Reitz, Shaojuan Jia, E Jon Jacobsen

J Med Chem· July 2006

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Effect of perioperative beta blockade in patients with diabetes undergoing major non-cardiac surgery: randomised placebo controlled, blinded multicentre trial.
Anne Benedicte Juul, Jørn Wetterslev, Christian Gluud, Allan Kofoed-Enevoldsen, Gorm Jensen, Jon Jacobsen

BMJ· June 2006

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Aza-cope rearrangement-mannich cyclizations for the formation of complex tricyclic amines: stereocontrolled total synthesis of (+/-)-gelsemine.
William G Earley, Jon E Jacobsen, Andrew Madin, G Patrick Meier, Christopher J O'Donnell

J Am Chem Soc· December 2005

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Co-crystallization of Staphylococcus aureus peptide deformylase (PDF) with potent inhibitors.
Melissa S Harris, Jeffrey H Bock, Gil Choi, Joyce S Cialdella, Kimberly A Curry, E Jon Jacobsen

Acta Crystallogr D Biol Crystallogr· December 2002

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