Publications by authors named "Jonas Helma"

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TUB-040, a Homogeneous and Hydrophilic NaPi2b-Targeting ADC with Stably Linked Exatecan, Exhibits Long-lasting Antitumor Activity and a Well-Tolerated Safety Profile.
Annette M Vogl, Saskia Schmitt, Isabelle Mai, Paul Machui, Sarah Herterich, Jonas Helma

Mol Cancer Ther· November 2025

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TUB-010, a novel anti-CD30 antibody-drug conjugate based on Tub-tag technology, widens the therapeutic window by reducing toxicity while maintaining high efficacy.
Marcus Gerlach, Saskia Schmitt, Philipp Cyprys, Marc-André Kasper, Isabelle Mai, Jonas Helma

Mol Cancer Ther· August 2025

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Orthogonal Site-Specific Dual Bioconjugation of Aryl and Alkyl Thiols.
Mark A R de Geus, Christian E Stieger, Jan Vincent V Arafiles, Jean-Romain P J Lotthé, Peter Schmieder, Jonas Helma

J Am Chem Soc· June 2025

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Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates.
Marina Able, Marc-André Kasper, Binje Vick, Jonathan Schwach, Xiang Gao, Jonas Helma

Leukemia· March 2025

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Design and Evaluation of Phosphonamidate-Linked Exatecan Constructs for Highly Loaded, Stable, and Efficacious Antibody-Drug Conjugates.
Saskia Schmitt, Paul Machui, Isabelle Mai, Sarah Herterich, Swetlana Wunder, Jonas Helma

Mol Cancer Ther· February 2024

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Compact hydrophilic electrophiles enable highly efficacious high DAR ADCs with excellent PK profile.
Philipp Ochtrop, Jahaziel Jahzerah, Paul Machui, Isabelle Mai, Dominik Schumacher, Jonas Helma

Chem Sci· March 2023

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Site-Specific Antibody Fragment Conjugates for Reversible Staining in Fluorescence Microscopy.
Jonathan Schwach, Ksenia Kolobynina, Katharina Brandstetter, Marcus Gerlach, Philipp Ochtrop, Jonas Helma

Chembiochem· April 2021

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One-Step Fluorescent Protein Labeling by Tubulin Tyrosine Ligase.
Dominik Schumacher, Heinrich Leonhardt, Christian P R Hackenberger, Jonas Helma

Methods Mol Biol· April 2020

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Tubulin Tyrosine Ligase-Mediated Modification of Proteins.
Marcus Gerlach, Tina Stoschek, Heinrich Leonhardt, Christian P R Hackenberger, Dominik Schumacher, Jonas Helma

Methods Mol Biol· March 2020

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N-Hydroxysuccinimide-Modified Ethynylphosphonamidates Enable the Synthesis of Configurationally Defined Protein Conjugates.
Marc-André Kasper, Marcus Gerlach, Anselm F L Schneider, Christiane Groneberg, Philipp Ochtrop, Jonas Helma

Chembiochem· January 2020

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Nanoparticle mediated delivery and small molecule triggered activation of proteins in the nucleus.
Hsin-Yi Chiu, Jack A Bates, Jonas Helma, Hanna Engelke, Hartmann Harz

Nucleus· September 2019

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Cysteine-Selective Phosphonamidate Electrophiles for Modular Protein Bioconjugations.
Marc-André Kasper, Maria Glanz, Andreas Stengl, Martin Penkert, Simon Klenk, Jonas Helma

Angew Chem Int Ed Engl· August 2019

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Ethynylphosphonamidates for the Rapid and Cysteine-Selective Generation of Efficacious Antibody-Drug Conjugates.
Marc-André Kasper, Andreas Stengl, Philipp Ochtrop, Marcus Gerlach, Tina Stoschek, Jonas Helma

Angew Chem Int Ed Engl· August 2019

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TuPPL: Tub-tag mediated C-terminal protein-protein-ligation using complementary click-chemistry handles.
Andreas Stengl, Marcus Gerlach, Marc-André Kasper, Christian P R Hackenberger, Heinrich Leonhardt, Jonas Helma

Org Biomol Chem· May 2019

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FLEXamers: A Double Tag for Universal Generation of Versatile Peptide-MHC Multimers.
Manuel Effenberger, Andreas Stengl, Kilian Schober, Maria Gerget, Maximilian Kampick, Jonas Helma

J Immunol· April 2019

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Tub-Tag Labeling; Chemoenzymatic Incorporation of Unnatural Amino Acids.
Jonas Helma, Heinrich Leonhardt, Christian P R Hackenberger, Dominik Schumacher

Methods Mol Biol· December 2018

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Nanobodies: Chemical Functionalization Strategies and Intracellular Applications.
Dominik Schumacher, Jonas Helma, Anselm F L Schneider, Heinrich Leonhardt, Christian P R Hackenberger

Angew Chem Int Ed Engl· February 2018

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Broad substrate tolerance of tubulin tyrosine ligase enables one-step site-specific enzymatic protein labeling.
Dominik Schumacher, Oliver Lemke, Jonas Helma, Lena Gerszonowicz, Verena Waller

Chem Sci· May 2017

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A Simple and Sensitive High-Content Assay for the Characterization of Antiproliferative Therapeutic Antibodies.
Andreas Stengl, David Hörl, Heinrich Leonhardt, Jonas Helma

SLAS Discov· March 2017

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Intracellular Delivery of Nanobodies for Imaging of Target Proteins in Live Cells.
Ruth Röder, Jonas Helma, Tobias Preiß, Joachim O Rädler, Heinrich Leonhardt

Pharm Res· January 2017

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Current Status: Site-Specific Antibody Drug Conjugates.
Dominik Schumacher, Christian P R Hackenberger, Heinrich Leonhardt, Jonas Helma

J Clin Immunol· May 2016

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Intracellular chromobody delivery by mesoporous silica nanoparticles for antigen targeting and visualization in real time.
Hsin-Yi Chiu, Wen Deng, Hanna Engelke, Jonas Helma, Heinrich Leonhardt

Sci Rep· May 2016

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Versatile and Efficient Site-Specific Protein Functionalization by Tubulin Tyrosine Ligase.
Dominik Schumacher, Jonas Helma, Florian A Mann, Garwin Pichler, Francesco Natale

Angew Chem Int Ed Engl· November 2015

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Nanobodies and recombinant binders in cell biology.
Jonas Helma, M Cristina Cardoso, Serge Muyldermans, Heinrich Leonhardt

J Cell Biol· June 2015

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Visualization and targeted disruption of protein interactions in living cells.
Henry D Herce, Wen Deng, Jonas Helma, Heinrich Leonhardt, M Cristina Cardoso

Nat Commun· June 2014

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