Publications by authors named "Jorge Beleta"

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The in vitro and in vivo profile of aclidinium bromide in comparison with glycopyrronium bromide.
Amadeu Gavaldà, Israel Ramos, Carla Carcasona, Elena Calama, Raquel Otal, Jorge Beleta

Pulm Pharmacol Ther· August 2014

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Pharmacological characterization of abediterol, a novel inhaled β(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.
Mònica Aparici, Mireia Gómez-Angelats, Dolors Vilella, Raquel Otal, Carla Carcasona, Jorge Beleta

J Pharmacol Exp Ther· August 2012

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Aclidinium bromide, a novel long-acting muscarinic antagonist for COPD with improved preclinical renal and urinary safety profile.
Amadeu Gavaldà, Jordi Gras, Josep Llupià, Jordi Aubets, Jorge Beleta

Life Sci· February 2012

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Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.
Joan Taltavull, Jordi Serrat, Jordi Gràcia, Amadeu Gavaldà, Mònica Córdoba, Jorge Beleta

Eur J Med Chem· October 2011

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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Maria Prat, María Antonia Buil, Maria Dolors Fernández, Jordi Castro, Juan Manuel Monleón, Jorge Beleta

Bioorg Med Chem Lett· June 2011

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Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors.
Joan Taltavull, Jordi Serrat, Jordi Gràcia, Amadeu Gavaldà, Míriam Andrés, Jorge Beleta

J Med Chem· October 2010

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Aclidinium bromide, a new, long-acting, inhaled muscarinic antagonist: in vitro plasma inactivation and pharmacological activity of its main metabolites.
Sonia Sentellas, Israel Ramos, Joan Albertí, Miquel Salvà, Francisca Antón, Jorge Beleta

Eur J Pharm Sci· March 2010

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Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.
Amadeu Gavaldà, Montserrat Miralpeix, Israel Ramos, Raquel Otal, Cristina Carreño, Jorge Beleta

J Pharmacol Exp Ther· November 2009

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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
María Prat, Dolors Fernández, M Antonia Buil, María I Crespo, Gaspar Casals, Jorge Beleta

J Med Chem· August 2009

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A new chemical tool (C0036E08) supports the role of adenosine A(2B) receptors in mediating human mast cell activation.
Montserrat Buceta, Eduardo Domínguez, Marián Castro, José Brea, David Alvarez, Jorge Beleta

Biochem Pharmacol· October 2008

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Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.
Bernat Vidal, Arsenio Nueda, Cristina Esteve, Teresa Domenech, Sonia Benito, Jorge Beleta

J Med Chem· May 2007

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New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.
Cristina Esteve, Arsenio Nueda, José Luis Díaz, Jorge Beleta, Alvaro Cárdenas

Bioorg Med Chem Lett· July 2006

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Phosphodiesterase 7A1 is expressed in human CD4+ naïve T cells at higher levels than in CD4+ memory cells and is not required during their CD3/CD28-dependent activation.
Arsenio Nueda, Nuria García-Roger, Teresa Domenech, Nuria Godessart, Alvaro Cárdenas, Jorge Beleta

Cell Immunol· July 2006

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Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists.
Silvia Fonquerna, Montse Miralpeix, Lluís Pagès, Carles Puig, Arantxa Cardús, Jorge Beleta

Bioorg Med Chem Lett· February 2005

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Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.
Silvia Fonquerna, Montse Miralpeix, Lluís Pagès, Carles Puig, Arantxa Cardús, Jorge Beleta

J Med Chem· December 2004

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Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents.
Vittorio Dal Piaz, Maria Carla Castellana, Claudia Vergelli, Maria Paola Giovannoni, Amadeu Gavaldà, Jorge Beleta

J Enzyme Inhib Med Chem· August 2002

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