Publications by authors named "Joseph DeGeorge"

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Stress convulsions in rodents: within a weight-of-evidence framework for human seizure risk.
Joseph J DeGeorge, Monica R Metea

Front Toxicol· July 2025

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A Brief History of Use of Animals in Biomedical Research and Perspective on Non-Animal Alternatives.
Lewis B Kinter, Ron DeHaven, David K Johnson, Joseph J DeGeorge

ILAR J· December 2021

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Fit for Purpose Assessment: A New Direction for IACUCs.
Lewis B Kinter, David K Johnson, Robert H Weichbrod, Ernest D Prentice, Richard C Simmonds, Joseph DeGeorge

ILAR J· December 2021

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Exposure assessments in reproductive and developmental toxicity testing: An IQ-DruSafe industry survey on current practices and experiences in support of exposure-based high dose selection.
Paul A Andrews, Mary Ellen McNerney, Joseph J DeGeorge

Regul Toxicol Pharmacol· October 2019

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Analysis of exposure margins in developmental toxicity studies for detection of human teratogens.
Paul A Andrews, Diann Blanset, Priscila Lemos Costa, Martin Green, Maia L Green, Joseph J DeGeorge

Regul Toxicol Pharmacol· July 2019

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An Industry Perspective on the 2017 EMA Guideline on First-in-Human and Early Clinical Trials.
Joseph DeGeorge, Sarah Robertson, Lynne Butler, Mazin Derzi, S Aubrey Stoch

Clin Pharmacol Ther· April 2018

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Current nonclinical testing paradigms in support of safe clinical trials: An IQ Consortium DruSafe perspective.
Lynne D Butler, Peggy Guzzie-Peck, James Hartke, Matthew S Bogdanffy, Yvonne Will, Joseph J DeGeorge

Regul Toxicol Pharmacol· July 2017

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Characterization of an investigative safety pharmacology model to assess comprehensive cardiac function and structure in chronically instrumented conscious beagle dogs.
Christopher P Regan, Gary L Stump, Theodore J Detwiler, Li Chen, Hillary K Regan, Joseph J DeGeorge

J Pharmacol Toxicol Methods· May 2017

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Cardiac drug-drug interaction between HCV-NS5B pronucleotide inhibitors and amiodarone is determined by their specific diastereochemistry.
Armando Lagrutta, Christopher P Regan, Haoyu Zeng, John P Imredy, Kenneth Koeplinger, Joseph DeGeorge

Sci Rep· March 2017

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Role of chronic toxicology studies in revealing new toxicities.
Alema Galijatovic-Idrizbegovic, Judith E Miller, Wendy D Cornell, James A Butler, Gordon K Wollenberg, Joseph J DeGeorge

Regul Toxicol Pharmacol· December 2016

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Scientific Knowledge and Technology, Animal Experimentation, and Pharmaceutical Development.
Lewis B Kinter, Joseph J DeGeorge

ILAR J· December 2016

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Assessment of the clinical cardiac drug-drug interaction associated with the combination of hepatitis C virus nucleotide inhibitors and amiodarone in guinea pigs and rhesus monkeys.
Christopher P Regan, Pierre Morissette, Hillary K Regan, Jeffery J Travis, Pamela Gerenser, Joseph J DeGeorge

Hepatology· November 2016

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Interaction between amiodarone and hepatitis-C virus nucleotide inhibitors in human induced pluripotent stem cell-derived cardiomyocytes and HEK-293 Cav1.2 over-expressing cells.
Armando Lagrutta, Haoyu Zeng, John Imredy, Bharathi Balasubramanian, Spencer Dech, Joseph DeGeorge

Toxicol Appl Pharmacol· October 2016

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Toxicogenomics in drug development: a match made in heaven?
Chunhua Qin, Keith Q Tanis, Alexei A Podtelezhnikov, Warren E Glaab, Frank D Sistare, Joseph J DeGeorge

Expert Opin Drug Metab Toxicol· August 2016

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An Evaluation of the Impact of PD-1 Pathway Blockade on Reproductive Safety of Therapeutic PD-1 Inhibitors.
Frederique M Poulet, Jayanthi J Wolf, Danuta J Herzyk, Joseph J DeGeorge

Birth Defects Res B Dev Reprod Toxicol· April 2016

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Regulatory Forum Commentary* Counterpoint: Dose Selection for Tg.rasH2 Mouse Carcinogenicity Studies.
Jarig Darbes, Frank D Sistare, Joseph J DeGeorge

Toxicol Pathol· July 2015

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Recommendations from a global cross-company data sharing initiative on the incorporation of recovery phase animals in safety assessment studies to support first-in-human clinical trials.
Fiona Sewell, Kathryn Chapman, Paul Baldrick, David Brewster, Alan Broadmeadow, Joseph DeGeorge

Regul Toxicol Pharmacol· October 2014

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Phenazin-5-ium hydrogen sulfate monohydrate.
Joseph Degeorge, Christopher P Landee, Mark M Turnbull

Acta Crystallogr Sect E Struct Rep Online· April 2013

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Importance of halogen···halogen contacts for the structural and magnetic properties of CuX2(pyrazine-N,N′-dioxide)(H2O)2 (X = Cl and Br).
John A Schlueter, Hyunsoo Park, Gregory J Halder, William R Armand, Cortney Dunmars, Joseph deGeorge

Inorg Chem· February 2012

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Promise of new translational safety biomarkers in drug development and challenges to regulatory qualification.
Frank D Sistare, Joseph J DeGeorge

Biomark Med· August 2011

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An analysis of pharmaceutical experience with decades of rat carcinogenicity testing: support for a proposal to modify current regulatory guidelines.
Frank D Sistare, Daniel Morton, Carl Alden, Joel Christensen, Douglas Keller, Joseph J DeGeorge

Toxicol Pathol· June 2011

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An industry perspective on the utility of short-term carcinogenicity testing in transgenic mice in pharmaceutical development.
Richard D Storer, Frank D Sistare, M Vijayaraj Reddy, Joseph J DeGeorge

Toxicol Pathol· January 2010

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Safety assessment of drug metabolites: implications of regulatory guidance and potential application of genetically engineered mouse models that express human P450s.
Mark W Powley, Clay B Frederick, Frank D Sistare, Joseph J DeGeorge

Chem Res Toxicol· February 2009

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Applications of toxicogenomics to nonclinical drug development: regulatory science considerations.
Frank D Sistare, Joseph J Degeorge

Methods Mol Biol· August 2008

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A rationale for determining, testing, and controlling specific impurities in pharmaceuticals that possess potential for genotoxicity.
Lutz Müller, Robert J Mauthe, Christopher M Riley, Marta M Andino, David De Antonis, Joseph DeGeorge

Regul Toxicol Pharmacol· April 2006

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