Publications by authors named "Josephine Giles"

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Tissue-resident exhausted and memory CD8 T cells have distinct ontogeny, function and role in disease.
Simone L Park, Mark M Painter, Sasikanth Manne, Victor Alcalde, Maura McLaughlin, Josephine R Giles

Nat Immunol· January 2026

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Divergent ontogeny of Tissue Resident Memory and Tissue Resident Exhausted CD8 T cells underlies distinct functional potential.
Simone L Park, Mark M Painter, Sasikanth Manne, Victor Alcalde, Maura McLaughlin, Josephine R Giles

bioRxiv· August 2025

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Deciphering the role of histone modifications in memory and exhausted CD8 T cells.
Hua Huang, Amy E Baxter, Zhen Zhang, Charly R Good, Katherine A Alexander, Josephine R Giles

Sci Rep· May 2025

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Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate.
Yinghui J Huang, Shin Foong Ngiow, Amy E Baxter, Sasikanth Manne, Simone L Park, Josephine R Giles

Sci Immunol· March 2025

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KLF2 maintains lineage fidelity and suppresses CD8 T cell exhaustion during acute LCMV infection.
Eric Fagerberg, John Attanasio, Christine Dien, Jaiveer Singh, Emily A Kessler, Josephine R Giles

Science· January 2025

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Revitalizing systemic immune responses in advanced NSCLC using FLT3L and SBRT.
Divij Mathew, Nitin Ohri, Shin Foong Ngiow, Balazs Halmos, K C Wumesh, Josephine R Giles

medRxiv· January 2025

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TET2 regulates early and late transitions in exhausted CD8 T cell differentiation and limits CAR T cell function.
Alexander J Dimitri, Amy E Baxter, Gregory M Chen, Caitlin R Hopkins, Geoffrey T Rouin, Josephine R Giles

Sci Adv· November 2024

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Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 T cells.
Kevin Wang, Paulina Coutifaris, David Brocks, Guanning Wang, Tarek Azar, Josephine Giles

Cancer Cell· September 2024

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LAG-3 sustains TOX expression and regulates the CD94/NKG2-Qa-1b axis to govern exhausted CD8 T cell NK receptor expression and cytotoxicity.
Shin Foong Ngiow, Sasikanth Manne, Yinghui Jane Huang, Tarek Azar, Zeyu Chen, Josephine R Giles

Cell· August 2024

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Combined JAK inhibition and PD-1 immunotherapy for non-small cell lung cancer patients.
Divij Mathew, Melina E Marmarelis, Caitlin Foley, Joshua M Bauml, Darwin Ye, Josephine R Giles

Science· June 2024

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Publisher Correction: Advancing T cell-based cancer therapy with single-cell technologies.
Samantha L Bucktrout, Nicholas E Banovich, Lisa H Butterfield, Cansu Cimen-Bozkus, Josephine R Giles

Nat Med· May 2024

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Author Correction: Trimodal single-cell profiling reveals a novel pediatric CD8αα T cell subset and broad age-related molecular reprogramming across the T cell compartment.
Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Cole Phalen, Josephine R Giles

Nat Immunol· March 2024

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Stat5 opposes the transcription factor Tox and rewires exhausted CD8 T cells toward durable effector-like states during chronic antigen exposure.
Jean-Christophe Beltra, Mohamed S Abdel-Hakeem, Sasikanth Manne, Zhen Zhang, Hua Huang, Josephine R Giles

Immunity· December 2023

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Trimodal single-cell profiling reveals a novel pediatric CD8αα T cell subset and broad age-related molecular reprogramming across the T cell compartment.
Zachary Thomson, Ziyuan He, Elliott Swanson, Katherine Henderson, Cole Phalen, Josephine R Giles

Nat Immunol· November 2023

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Prior vaccination promotes early activation of memory T cells and enhances immune responses during SARS-CoV-2 breakthrough infection.
Mark M Painter, Timothy S Johnston, Kendall A Lundgreen, Jefferson J S Santos, Juliana S Qin, Josephine R Giles

Nat Immunol· October 2023

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CD8 T cells in the cancer-immunity cycle.
Josephine R Giles, Anna-Maria Globig, Susan M Kaech, E John Wherry

Immunity· October 2023

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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR CD8 effector state, and its deletion improves checkpoint blockade.
Susan E McClory, Oishi Bardhan, Kelly S Rome, Josephine R Giles, Amy E Baxter

Cell Rep· August 2023

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In vitro modeling of CD8 T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40.
Jennifer E Wu, Sasikanth Manne, Shin Foong Ngiow, Amy E Baxter, Hua Huang, Josephine R Giles

Sci Immunol· August 2023

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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8 T cells.
Amy E Baxter, Hua Huang, Josephine R Giles, Zeyu Chen, Jennifer E Wu

Immunity· June 2023

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Modeling of CD8 T Cell Exhaustion Enables CRISPR Screening to Reveal a Role for BHLHE40.
Jennifer E Wu, Sasikanth Manne, Shin Foong Ngiow, Amy E Baxter, Hua Huang, Josephine R Giles

bioRxiv· April 2023

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Prior vaccination enhances immune responses during SARS-CoV-2 breakthrough infection with early activation of memory T cells followed by production of potent neutralizing antibodies.
Mark M Painter, Timothy S Johnston, Kendall A Lundgreen, Jefferson J S Santos, Juliana S Qin, Josephine R Giles

bioRxiv· February 2023

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The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR CD8 effector state and its deletion improves checkpoint blockade.
Susan E McClory, Oishi Bardhan, Kelly S Rome, Josephine R Giles, Amy E Baxter

bioRxiv· February 2023

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Shared and distinct biological circuits in effector, memory and exhausted CD8 T cells revealed by temporal single-cell transcriptomics and epigenetics.
Josephine R Giles, Shin Foong Ngiow, Sasikanth Manne, Amy E Baxter, Omar Khan

Nat Immunol· November 2022

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Divergent clonal differentiation trajectories of T cell exhaustion.
Bence Daniel, Kathryn E Yost, Sunnie Hsiung, Katalin Sandor, Yu Xia, Josephine R Giles

Nat Immunol· November 2022

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Advancing T cell-based cancer therapy with single-cell technologies.
Samantha L Bucktrout, Nicholas E Banovich, Lisa H Butterfield, Cansu Cimen-Bozkus, Josephine R Giles

Nat Med· September 2022

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