Publications by authors named "Judith Gottwein"

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SARS-CoV-2 Mpro inhibitor ensitrelvir: asymmetrical cross-resistance with nirmatrelvir and emerging resistance hotspots.
Yuyong Zhou, Karen A Gammeltoft, Helena D Tjørnelund-Sjursen, Line A Ryberg, Anna Offersgaard, Judith M Gottwein

Emerg Microbes Infect· December 2025

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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul, Halise Busra Cagirici, Judith Gottwein

Nat Commun· July 2025

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Bispecific antibodies against the hepatitis C virus E1E2 envelope glycoprotein.
Laura Radić, Anna Offersgaard, Tereza Kadavá, Ian Zon, Joan Capella-Pujol, Judith M Gottwein

Proc Natl Acad Sci U S A· April 2025

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Intranasal recombinant protein subunit vaccine targeting TLR3 induces respiratory tract IgA and CD8 T cell responses and protects against respiratory virus infection.
Katharina Wørzner, Signe Tandrup Schmidt, Julie Zimmermann, Ahmad Tami, Charlotta Polacek, Judith Gottwein

EBioMedicine· March 2025

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JFH1-based Core-NS2 genotype variants of HCV with genetic stability in vivo and in vitro: Important tools in the evaluation of virus neutralization.
Laura Collignon, Kenn Holmbeck, Ashley Just, Lieven Verhoye, Rodrigo Velázquez-Moctezuma, Judith M Gottwein

Hepatology· November 2024

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Replication capacity and susceptibility of nirmatrelvir-resistant mutants to next-generation Mpro inhibitors in a SARS-CoV-2 replicon system.
Chieh-Wen Lo, Omri Kariv, Chenzhou Hao, Karen Anbro Gammeltoft, Jens Bukh, Judith Gottwein

Antiviral Res· November 2024

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An inactivated SARS-CoV-2 vaccine based on a Vero cell culture-adapted high-titer virus confers cross-protection in small animals.
Anna Offersgaard, Carlos R Duarte Hernandez, Yuyong Zhou, Zhe Duan, Karen Anbro Gammeltoft, Judith Margarete Gottwein

Sci Rep· July 2024

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PIP4K2C inhibition reverses autophagic flux impairment induced by SARS-CoV-2.
Marwah Karim, Manjari Mishra, Chieh-Wen Lo, Sirle Saul, Halise Busra Cagirici, Judith Gottwein

bioRxiv· April 2024

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Substitutions in SARS-CoV-2 Mpro Selected by Protease Inhibitor Boceprevir Confer Resistance to Nirmatrelvir.
Karen Anbro Gammeltoft, Yuyong Zhou, Line Abildgaard Ryberg, Long V Pham, Alekxander Binderup, Judith Margarete Gottwein

Viruses· September 2023

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Characterization of multi-DAA resistance using a novel hepatitis C virus genotype 3a infectious culture system.
Carlota Fernandez-Antunez, Kuan Wang, Ulrik Fahnøe, Lotte S Mikkelsen, Judith M Gottwein

Hepatology· August 2023

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Hepatitis C virus RNA is 5'-capped with flavin adenine dinucleotide.
Anna V Sherwood, Lizandro R Rivera-Rangel, Line A Ryberg, Helena S Larsen, Klara M Anker, Judith M Gottwein

Nature· July 2023

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Toward a vaccine against hepatitis C virus.
Anna Offersgaard, Jens Bukh, Judith M Gottwein

Science· April 2023

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Inactivated genotype 1a, 2a and 3a HCV vaccine candidates induced broadly neutralising antibodies in mice.
Garazi Pena Alzua, Anne Finne Pihl, Anna Offersgaard, Carlos Rene Duarte Hernandez, Zhe Duan, Judith Margarete Gottwein

Gut· March 2023

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Identification of novel neutralizing determinants for protection against HCV.
Garazi P Alzua, Anne F Pihl, Anna Offersgaard, Rodrigo Velázquez-Moctezuma, Carlos R Duarte Hernandez, Judith M Gottwein

Hepatology· March 2023

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An inactivated SARS-CoV-2 vaccine induced cross-neutralizing persisting antibodies and protected against challenge in small animals.
Anna Offersgaard, Carlos Rene Duarte Hernandez, Shan Feng, Pavel Marichal-Gallardo, Kenn Holmbeck, Judith Margarete Gottwein

iScience· February 2023

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Effect of Glycan Shift on Antibodies against Hepatitis C Virus E2 412-425 Epitope Elicited by Chimeric sHBsAg-Based Virus-Like Particles.
Anna Czarnota, Anna Offersgaard, Ania Owsianka, Garazi Peña Alzua, Jens Bukh, Judith Margarete Gottwein

Microbiol Spectr· January 2023

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Nirmatrelvir-resistant SARS-CoV-2 variants with high fitness in an infectious cell culture system.
Yuyong Zhou, Karen Anbro Gammeltoft, Line Abildgaard Ryberg, Long V Pham, Helena Damtoft Tjørnelund, Judith Margarete Gottwein

Sci Adv· December 2022

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Inactivated whole hepatitis C virus vaccine employing a licensed adjuvant elicits cross-genotype neutralizing antibodies in mice.
Anne Finne Pihl, Shan Feng, Anna Offersgaard, Garazi Peña Alzua, Elias Honerød Augestad, Judith Margarete Gottwein

J Hepatol· May 2022

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High-Titer Hepatitis C Virus Production in a Scalable Single-Use High Cell Density Bioreactor.
Anna Offersgaard, Carlos Rene Duarte Hernandez, Anne Finne Pihl, Nandini Prabhakar Venkatesan, Henrik Krarup, Judith Margarete Gottwein

Vaccines (Basel)· February 2022

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Versatile SARS-CoV-2 Reverse-Genetics Systems for the Study of Antiviral Resistance and Replication.
Ulrik Fahnøe, Long V Pham, Carlota Fernandez-Antunez, Rui Costa, Lizandro René Rivera-Rangel, Judith M Gottwein

Viruses· January 2022

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Antigenic and immunogenic evaluation of permutations of soluble hepatitis C virus envelope protein E2 and E1 antigens.
Jannick Prentoe, Christoph M Janitzek, Rodrigo Velázquez-Moctezuma, Louise Goksøyr, Rebecca W Olsen, Judith M Gottwein

PLoS One· November 2021

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Efficacy of Ion-Channel Inhibitors Amantadine, Memantine and Rimantadine for the Treatment of SARS-CoV-2 In Vitro.
Yuyong Zhou, Karen A Gammeltoft, Andrea Galli, Anna Offersgaard, Ulrik Fahnøe, Judith M Gottwein

Viruses· October 2021

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Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 .
Karen A Gammeltoft, Yuyong Zhou, Carlos R Duarte Hernandez, Andrea Galli, Anna Offersgaard, Judith M Gottwein

Antimicrob Agents Chemother· August 2021

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In vitro efficacy of artemisinin-based treatments against SARS-CoV-2.
Yuyong Zhou, Kerry Gilmore, Santseharay Ramirez, Eva Settels, Karen A Gammeltoft, Judith M Gottwein

Sci Rep· July 2021

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SARS-CoV-2 Production in a Scalable High Cell Density Bioreactor.
Anna Offersgaard, Carlos Rene Duarte Hernandez, Anne Finne Pihl, Rui Costa, Nandini Prabhakar Venkatesan, Judith Margarete Gottwein

Vaccines (Basel)· June 2021

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