Publications by authors named "Junfa Fan"

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.
Brian T Hopkins, Eris Bame, Noah Bell, Tonika Bohnert, Jon K Bowden-Verhoek, Junfa Fan

Bioorg Med Chem· August 2021

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Optimization of novel reversible Bruton's tyrosine kinase inhibitors identified using Tethering-fragment-based screens.
Brian T Hopkins, Eris Bame, Noah Bell, Tonika Bohnert, Jon K Bowden-Verhoek, Junfa Fan

Bioorg Med Chem· July 2019

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Modifications of the isonipecotic acid fragment of SNS-032: analogs with improved permeability and lower efflux ratio.
Junfa Fan, Bruce Fahr, David Stockett, Erica Chan, Sravanthi Cheeti, Yafan Lu

Bioorg Med Chem Lett· December 2008

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A diaminocyclohexyl analog of SNS-032 with improved permeability and bioavailability properties.
Ingrid C Choong, Iana Serafimova, Junfa Fan, David Stockett, Erica Chan, Yafan Lu

Bioorg Med Chem Lett· November 2008

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Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.
Raymond V Fucini, Emily J Hanan, Michael J Romanowski, Robert A Elling, Willard Lew, Junfa Fan, Yafan Lu

Bioorg Med Chem Lett· October 2008

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Synthesis of (E)- and (Z)-alpha,beta-Difluorourocanic Acid.
Jan Hajduch, Bohumil Dolenský, Shinichi Yoshida, Junfa Fan, Kenneth L Kirk

J Fluor Chem· February 2008

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In vitro properties of antimicrobial bromotyrosine alkaloids.
Neora Pick, Mamta Rawat, Dorit Arad, Jiong Lan, Junfa Fan

J Med Microbiol· April 2006

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Total synthesis of (+/-)-alantrypinone by hetero Diels-Alder reaction.
Zecheng Chen, Junfa Fan, Andrew S Kende

J Org Chem· January 2004

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A concise total synthesis of (+/-)-alantrypinone by a novel hetero-Diels-Alder reaction.
Andrew S Kende, Junfa Fan, Zecheng Chen

Org Lett· September 2003

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Syntheses of beta,beta-difluorotryptamines.
Wei-Ping Deng, Ghilsoo Nam, Junfa Fan, Kenneth L Kirk

J Org Chem· April 2003

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Convenient syntheses of biogenic aldehydes, 3,4-dihydroxyphenylacetaldehyde and 3,4-dihydroxyphenylglycolaldehyde.
Jayan Narayanan, Yoshio Hayakawa, Junfa Fan, Kenneth L Kirk

Bioorg Chem· April 2003

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