Publications by authors named "Justin Gu"

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Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
Ying Huang, Martin Sendzik, Jeff Zhang, Zhenting Gao, Yongfeng Sun, Justin Gu

J Med Chem· April 2022

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Upregulation of CD11b and CD86 through LSD1 inhibition promotes myeloid differentiation and suppresses cell proliferation in human monocytic leukemia cells.
Jianwu Fang, Haiyan Ying, Ting Mao, Yanjia Fang, Yuan Lu, Justin Gu

Oncotarget· October 2017

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Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED.
Ling Li, Hailong Zhang, Man Zhang, Mengxi Zhao, Lijian Feng, Guobin Li, Justin Gu

PLoS One· August 2017

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Split luciferase-based biosensors for characterizing EED binders.
Ling Li, Lijian Feng, Minlong Shi, Jue Zeng, Zijun Chen, Weihui Guo, Justin Gu

Anal Biochem· April 2017

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An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of EED.
Wei Qi, Kehao Zhao, Justin Gu, Ying Huang, Youzhen Wang, Guobin Li

Nat Chem Biol· April 2017

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Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Ying Huang, Jeff Zhang, Zhengtian Yu, Hailong Zhang, Youzhen Wang, Justin Gu, Haibing Guo

J Med Chem· March 2017

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Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.
Andreas Lingel, Martin Sendzik, Ying Huang, Michael D Shultz, John Cantwell, Justin Gu

J Med Chem· January 2017

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Konstantinos J Mavrakis, E Robert McDonald, Michael R Schlabach, Eric Billy, Gregory R Hoffman, Guizhi Yang, Elizabeth R Sprague, Justin Gu

Science· March 2016

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A liquid chromatography/mass spectrometry-based generic detection method for biochemical assay and hit discovery of histone methyltransferases.
Shu Li, X Justin Gu, Qin Hao, Hong Fan, Ling Li

Anal Biochem· December 2013

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NSD2 is recruited through its PHD domain to oncogenic gene loci to drive multiple myeloma.
Zheng Huang, Haiping Wu, Shannon Chuai, Fiona Xu, Feng Yan, Justin Gu

Cancer Res· October 2013

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Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation.
Wei Qi, HoMan Chan, Lin Teng, Ling Li, Shannon Chuai, Justin Gu, Guobin Li

Proc Natl Acad Sci U S A· December 2012

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Detecting S-adenosyl-L-methionine-induced conformational change of a histone methyltransferase using a homogeneous time-resolved fluorescence-based binding assay.
Ying Lin, Hong Fan, Mathias Frederiksen, Kehao Zhao, Lei Jiang, Weihui Guo, X Justin Gu

Anal Biochem· April 2012

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Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
Li Wang, Ling Li, Hailong Zhang, Xiao Luo, Jingquan Dai, Justin Gu

J Biol Chem· November 2011

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Histone methylation by PRC2 is inhibited by active chromatin marks.
Frank W Schmitges, Archana B Prusty, Mahamadou Faty, Alexandra Stützer, Gondichatnahalli M Lingaraju, Justin Gu, Heinz Gut

Mol Cell· May 2011

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