Publications by authors named "Justin Louis"

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Discovery of ()-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
Guanglin Luo, Ling Chen, Walter A Kostich, Brian Hamman, Jason Allen, Justin V Louis

J Med Chem· March 2022

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Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
Guanglin Luo, Ling Chen, Walter A Kostich, Brian Hamman, Jason Allen, Justin V Louis

J Med Chem· March 2022

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Analgesic, Anti-Inflammatory, Cytotoxic Activity Screening and UPLC-PDA-ESI-MS Metabolites Determination of Bioactive Fractions of .
Mohammad Alfaifi, Abdulrhman Alsayari, Narasimman Gurusamy, Justin Louis, Serag Eldin Elbehairi

Molecules· January 2020

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Diminished responses to monoaminergic antidepressants but not ketamine in a mouse model for neuropsychiatric lupus.
Bettadapura N Srikumar, Pattipati S Naidu, Narasimharaju Kalidindi, Mahesh Paschapur, Bharath Adepu, Justin V Louis

J Psychopharmacol· January 2019

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Characterization of the adrenocorticotrophic hormone - induced mouse model of resistance to antidepressant drug treatment.
Bettadapura N Srikumar, Mahesh Paschapur, Narasimharaju Kalidindi, Bharath Adepu, Manish L Das, Justin V Louis

Pharmacol Biochem Behav· October 2017

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[H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement.
Justin V Louis, Yifeng Lu, Rick Pieschl, Yung Tian, Yang Hong

Neuropharmacology· May 2017

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Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
Walter Kostich, Brian D Hamman, Yu-Wen Li, Sreenivasulu Naidu, Kumaran Dandapani, Justin V Louis

J Pharmacol Exp Ther· September 2016

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Bacillus Calmette-Guérin vaccine induces a selective serotonin reuptake inhibitor (SSRI)-resistant depression like phenotype in mice.
K Vijaya Kumar, Anjuman Rudra, M V Sreedhara, T Siva Subramani, Durga Shiva Prasad, Justin V Louis

Brain Behav Immun· November 2014

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Increasing brain protein O-GlcNAc-ylation mitigates breathing defects and mortality of Tau.P301L mice.
Peter Borghgraef, Clément Menuet, Clara Theunis, Justin V Louis, Herman Devijver

PLoS One· October 2014

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Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
Hervé Maurin, Benoit Lechat, Ilse Dewachter, Laurence Ris, Justin V Louis

Mol Brain· May 2013

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Molecular implication of PP2A and Pin1 in the Alzheimer's disease specific hyperphosphorylation of Tau.
Isabelle Landrieu, Caroline Smet-Nocca, Laziza Amniai, Justin Vijay Louis, Jean-Michel Wieruszeski

PLoS One· November 2011

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GSK3 and Alzheimer's Disease: Facts and Fiction….
Anna Kremer, Justin V Louis, Tomasz Jaworski, Fred Van Leuven

Front Mol Neurosci· November 2011

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Mice lacking phosphatase PP2A subunit PR61/B'delta (Ppp2r5d) develop spatially restricted tauopathy by deregulation of CDK5 and GSK3beta.
Justin V Louis, Ellen Martens, Peter Borghgraef, Caroline Lambrecht, Ward Sents

Proc Natl Acad Sci U S A· April 2011

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Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A.
Karen Zwaenepoel, Justin V Louis, Jozef Goris, Veerle Janssens

BMC Genomics· August 2008

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Spatial control of protein phosphatase 2A (de)methylation.
Sari Longin, Karen Zwaenepoel, Ellen Martens, Justin V Louis, Evelien Rondelez

Exp Cell Res· January 2008

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Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.
Craig M Forester, Jessica Maddox, Justin V Louis, Jozef Goris, David M Virshup

Proc Natl Acad Sci U S A· December 2007

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Selection of protein phosphatase 2A regulatory subunits is mediated by the C terminus of the catalytic Subunit.
Sari Longin, Karen Zwaenepoel, Justin V Louis, Stephen Dilworth, Jozef Goris

J Biol Chem· September 2007

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