Publications by authors named "Justin Pritchard"

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Characterizing Variants of Uncertain Drug Resistance (VUDRs) Using Quantitative Measurements at Clinical Exposures.
Haider Inam, Marta Tomaszkiewicz, Joshua Reynolds, Zeyu Yang, Scott Leighow, Justin R Pritchard

bioRxiv· November 2025

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Efficient mathematical methodology to determine multistep mutant burden in spatially growing cell populations.
Natalia L Komarova, Justin R Pritchard, Dominik Wodarz

PNAS Nexus· September 2025

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A side-by-side comparison of variant function measurements using deep mutational scanning and base editing.
Ivan Sokirniy, Haider Inam, Marta Tomaszkiewicz, Joshua Reynolds, David McCandlish, Justin Pritchard

Nucleic Acids Res· July 2025

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Structural Identification of Major Molecular Determinants for Phosphotyrosine Recognition in Tyrosine Kinases Reveals Tumour Promoting and Suppressive Functions.
Nuo Cheng, Luis R Millán-Barea, Marc Creixell, Alexis R Barr, Yi Wen Kong, Justin Pritchard

bioRxiv· June 2025

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Programming tumor evolution with selection gene drives to proactively combat drug resistance.
Scott M Leighow, Joshua A Reynolds, Ivan Sokirniy, Shun Yao, Zeyu Yang, Justin R Pritchard

Nat Biotechnol· May 2025

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goloco: a web application to create genome scale information from surprisingly small experiments.
Sajid M Hossain, Yiyun Rao, Jahid O Hossain, Justin R Pritchard, Boyang Zhao

BMC Bioinformatics· February 2025

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A side-by-side comparison of variant function measurements using deep mutational scanning and base editing.
Ivan Sokirniy, Haider Inam, Marta Tomaszkiewicz, Joshua Reynolds, David McCandlish, Justin Pritchard

bioRxiv· September 2024

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Incorporating mutational heterogeneity to identify genes that are enriched for synonymous mutations in cancer.
Yiyun Rao, Nabeel Ahmed, Justin Pritchard, Edward P O'Brien

BMC Bioinformatics· December 2023

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Excessive concentrations of kinase inhibitors in translational studies impede effective drug repurposing.
Chuan Liu, Scott M Leighow, Kyle McIlroy, Mengrou Lu, Kady A Dennis, Justin R Pritchard

Cell Rep Med· October 2023

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Deciphering the Mechanistic Basis for Perfluoroalkyl-Protein Interactions.
Atip Lawanprasert, Janna N Sloand, Mariangely González Vargas, Harminder Singh, Tomer Eldor, Justin R Pritchard

Chembiochem· July 2023

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How soluble misfolded proteins bypass chaperones at the molecular level.
Ritaban Halder, Daniel A Nissley, Ian Sitarik, Yang Jiang, Yiyun Rao, Justin Pritchard

Nat Commun· June 2023

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The role of migration in mutant dynamics in fragmented populations.
Jesse Kreger, Donovan Brown, Natalia L Komarova, Dominik Wodarz, Justin Pritchard

J Evol Biol· February 2023

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Functional genomic analysis of adult and pediatric brain tumor isolates.
Pia Hoellerbauer, Matt C Biery, Sonali Arora, Yiyun Rao, Emily J Girard, Justin R Pritchard

bioRxiv· January 2023

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Agent-Based Models Help Interpret Patterns of Clinical Drug Resistance by Contextualizing Competition Between Distinct Drug Failure Modes.
Scott M Leighow, Ben Landry, Michael J Lee, Shelly R Peyton, Justin R Pritchard

Cell Mol Bioeng· October 2022

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Vascularized pancreas-on-a-chip device produced using a printable simulated extracellular matrix.
Monika Hospodiuk-Karwowski, Kai Chi, Justin Pritchard, Jeffrey M Catchmark

Biomed Mater· September 2022

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Self-assembled ruthenium and osmium nanosystems display a potent anticancer profile by interfering with metabolic activity.
Mickaël Marloye, Haider Inam, Connor J Moore, Tyler R Mertens, Aude Ingels, Justin R Pritchard

Inorg Chem Front· June 2022

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Materials-driven approaches to understand extrinsic drug resistance in cancer.
Justin R Pritchard, Michael J Lee, Shelly R Peyton

Soft Matter· May 2022

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SARS-CoV-2 Attack Rate and Population Immunity in Southern New England, March 2020 to May 2021.
Thu Nguyen-Anh Tran, Nathan B Wikle, Fuhan Yang, Haider Inam, Scott Leighow, Justin R Pritchard

JAMA Netw Open· May 2022

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Phase II Study of Ponatinib in Advanced Gastrointestinal Stromal Tumors: Efficacy, Safety, and Impact of Liquid Biopsy and Other Biomarkers.
Suzanne George, Margaret von Mehren, Jonathan A Fletcher, Jichao Sun, Sen Zhang, Justin R Pritchard

Clin Cancer Res· April 2022

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A pan-CRISPR analysis of mammalian cell specificity identifies ultra-compact sgRNA subsets for genome-scale experiments.
Boyang Zhao, Yiyun Rao, Scott Leighow, Edward P O'Brien, Luke Gilbert, Justin R Pritchard

Nat Commun· February 2022

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SARS-CoV-2 epidemic after social and economic reopening in three U.S. states reveals shifts in age structure and clinical characteristics.
Nathan B Wikle, Thu Nguyen-Anh Tran, Bethany Gentilesco, Scott M Leighow, Emmy Albert, Justin R Pritchard

Sci Adv· January 2022

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SARS-CoV-2 attack rate and population immunity in southern New England, March 2020 - May 2021.
Thu Nguyen-Anh Tran, Nathan B Wikle, Fuhan Yang, Haider Inam, Scott Leighow, Justin R Pritchard

medRxiv· December 2021

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SARS-CoV-2 epidemic after social and economic reopening in three US states reveals shifts in age structure and clinical characteristics.
Nathan Wikle, Thu Nguyen-Anh Tran, Bethany Gentilesco, Scott M Leighow, Joseph Albert, Justin R Pritchard

medRxiv· November 2021

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Genomic and experimental evidence that ALK does not predict single agent sensitivity to ALK inhibitors.
Haider Inam, Ivan Sokirniy, Yiyun Rao, Anushka Shah, Farnaz Naeemikia, Justin R Pritchard

iScience· November 2021

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A global cancer data integrator reveals principles of synthetic lethality, sex disparity and immunotherapy.
Christopher Yogodzinski, Abolfazl Arab, Justin R Pritchard, Hani Goodarzi, Luke A Gilbert

Genome Med· October 2021

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