Publications by authors named "Karen Augustine-Rauch"

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NFE2 and PF4 as biomarkers for BET inhibition-induced thrombocytopenia in preclinical and clinical studies.
Cindy Zhang, Ke Xu, Faye Wang, Jennifer Price, Julie Panzica, Karen Augustine-Rauch

Front Med (Lausanne)· September 2025

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Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor.
Yong Zhang, Karen E Parrish, David R Tortolani, Michael A Poss, Audris Huang, Karen Augustine-Rauch

J Med Chem· November 2021

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TGFβ2 and TGFβ3 mediate appropriate context-dependent phenotype of rat valvular interstitial cells.
Faye Wang, Cindy Zhang, Jae Kwagh, Brian Strassle, Jinqing Li, Karen Augustine-Rauch

iScience· March 2021

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T4-mediated rescue of aortic malformations in hypothyroid rats indicates maternal thyroid status can affect great vessel development.
Karen Augustine-Rauch, Jiin-Jia Liaw, Michael Graziano

Toxicol Appl Pharmacol· January 2021

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Intermittent dosing of the transforming growth factor beta receptor 1 inhibitor, BMS-986260, mitigates class-based cardiovascular toxicity in dogs but not rats.
Gregory D Rak, Melvin R White, Karen Augustine-Rauch, Courtni Newsome, Michael J Graziano

J Appl Toxicol· July 2020

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Discovery of BMS-986260, a Potent, Selective, and Orally Bioavailable TGFβR1 Inhibitor as an Immuno-oncology Agent.
Upender Velaparthi, Chetan Padmakar Darne, Jayakumar Warrier, Peiying Liu, Hasibur Rahaman, Karen Augustine-Rauch

ACS Med Chem Lett· February 2020

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Discovery of 4-Azaindole Inhibitors of TGFβRI as Immuno-oncology Agents.
Yong Zhang, Yufen Zhao, Andrew J Tebben, Steven Sheriff, Max Ruzanov, Karen Augustine-Rauch

ACS Med Chem Lett· November 2018

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In Vitro Developmental Toxicology Screens: A Report on the Progress of the Methodology and Future Applications.
Cindy Zhang, Jonathan Ball, Julie Panzica-Kelly, Karen Augustine-Rauch

Chem Res Toxicol· April 2016

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A Developmental Toxicology Assay Platform for Screening Teratogenic Liability of Pharmaceutical Compounds.
Karen Augustine-Rauch, Cindy X Zhang, Julieta M Panzica-Kelly

Birth Defects Res B Dev Reprod Toxicol· February 2016

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Optimization and Performance Assessment of the Chorion-Off [Dechorinated] Zebrafish Developmental Toxicity Assay.
Julieta M Panzica-Kelly, Cindy X Zhang, Karen A Augustine-Rauch

Toxicol Sci· July 2015

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Fishing for teratogens: a consortium effort for a harmonized zebrafish developmental toxicology assay.
Jonathan S Ball, Donald B Stedman, Jedd M Hillegass, Cindy X Zhang, Julie Panzica-Kelly, Karen A Augustine-Rauch

Toxicol Sci· May 2014

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The rat whole embryo culture assay using the Dysmorphology Score system.
Cindy Zhang, Julie Panzica-Kelly, Karen Augustine-Rauch

Methods Mol Biol· April 2013

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Establishment of a molecular embryonic stem cell developmental toxicity assay.
Julieta M Panzica-Kelly, Kimberly C Brannen, Yan Ma, Cindy X Zhang, Oliver P Flint, Karen A Augustine-Rauch

Toxicol Sci· February 2013

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Zebrafish embryo developmental toxicology assay.
Julieta M Panzica-Kelly, Cindy X Zhang, Karen Augustine-Rauch

Methods Mol Biol· September 2012

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Development of a streamlined rat whole embryo culture assay for classifying teratogenic potential of pharmaceutical compounds.
Cindy Zhang, June Cao, James R Kenyon, Julieta M Panzica-Kelly, Lei Gong, Karen Augustine-Rauch

Toxicol Sci· June 2012

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A dysmorphology score system for assessing embryo abnormalities in rat whole embryo culture.
Cindy X Zhang, Tracy Danberry, Mary Ann Jacobs, Karen Augustine-Rauch

Birth Defects Res B Dev Reprod Toxicol· December 2010

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Morphological score assignment guidelines for the dechorionated zebrafish teratogenicity assay.
Julieta M Panzica-Kelly, Cindy X Zhang, Tracy L Danberry, Annette Flood, Judiann W DeLan, Karen A Augustine-Rauch

Birth Defects Res B Dev Reprod Toxicol· October 2010

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In vitro developmental toxicology assays: A review of the state of the science of rodent and zebrafish whole embryo culture and embryonic stem cell assays.
Karen Augustine-Rauch, Cindy X Zhang, Julieta M Panzica-Kelly

Birth Defects Res C Embryo Today· June 2010

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Development of a zebrafish embryo teratogenicity assay and quantitative prediction model.
Kimberly C Brannen, Julieta M Panzica-Kelly, Tracy L Danberry, Karen A Augustine-Rauch

Birth Defects Res B Dev Reprod Toxicol· February 2010

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State of the art in developmental toxicity screening methods and a way forward: a meeting report addressing embryonic stem cells, whole embryo culture, and zebrafish.
Robert Chapin, Karen Augustine-Rauch, Bruce Beyer, George Daston, Richard Finnell

Birth Defects Res B Dev Reprod Toxicol· August 2008

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Alternative experimental approaches for interpreting skeletal findings in safety studies.
Karen Augustine-Rauch

Birth Defects Res B Dev Reprod Toxicol· December 2007

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Evidence for a molecular mechanism of teratogenicity of SB-236057, a 5-HT1B receptor inverse agonist that alters axial formation.
Karen A Augustine-Rauch, Qin J Zhang, Jennifer L Leonard, Antony Chadderton, Michael J Welsh

Birth Defects Res A Clin Mol Teratol· October 2004

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SB-236057: Critical window of sensitivity study and embryopathy of a potent musculoskeletal teratogen.
Karen A Augustine-Rauch, Qin J Zhang, Lorraine Posobiec, Rosanna Mirabile, Lisa S DeBoer

Birth Defects Res A Clin Mol Teratol· October 2004

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A study of vehicles for dosing rodent whole embryo culture with non aqueous soluble compounds.
Karen A Augustine-Rauch, Qin Zhang, Mark Kleinman, Richard Lawton, Michael J Welsh

Reprod Toxicol· May 2004

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Selection of normalizer genes in conducting relative gene expression analysis of embryos.
Qin J Zhang, Antony Chadderton, Robert L Clark, Karen A Augustine-Rauch

Birth Defects Res A Clin Mol Teratol· August 2003

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