Publications by authors named "Karin Reif"

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Layilin regulates Treg motility and suppressive capacity in skin.
Victoire Gouirand, Sean Clancy, Courtney Macon, Jose Valle, Mariela Pauli, Karin Reif

Elife· July 2025

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Stereochemical Differences in Fluorocyclopropyl Amides Enable Tuning of Btk Inhibition and Off-Target Activity.
James J Crawford, Wendy Lee, Adam R Johnson, Kelly J Delatorre, Jacob Chen, Karin Reif

ACS Med Chem Lett· August 2020

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Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton's Tyrosine Kinase Inhibitor in Early Clinical Development.
James J Crawford, Adam R Johnson, Dinah L Misner, Lisa D Belmont, Georgette Castanedo, Karin Reif

J Med Chem· March 2018

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Discovery of Potent and Selective Tricyclic Inhibitors of Bruton's Tyrosine Kinase with Improved Druglike Properties.
Xiaojing Wang, James Barbosa, Peter Blomgren, Meire C Bremer, Jacob Chen, Karin Reif

ACS Med Chem Lett· June 2017

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Btk-specific inhibition blocks pathogenic plasma cell signatures and myeloid cell-associated damage in IFN-driven lupus nephritis.
Arna Katewa, Yugang Wang, Jason A Hackney, Tao Huang, Eric Suto, Karin Reif

JCI Insight· April 2017

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Bruton's Tyrosine Kinase Small Molecule Inhibitors Induce a Distinct Pancreatic Toxicity in Rats.
Rebecca I Erickson, Leah K Schutt, Jacqueline M Tarrant, Michelle McDowell, Lichuan Liu, Karin Reif

J Pharmacol Exp Ther· January 2017

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Automated Affinity Capture and On-Tip Digestion to Accurately Quantitate in Vivo Deamidation of Therapeutic Antibodies.
John C Tran, Daniel Tran, Amy Hilderbrand, Nisana Andersen, Tao Huang, Karin Reif

Anal Chem· December 2016

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Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.
Kathila S Rajapaksa, Tao Huang, Neeraj Sharma, Shannon Liu, Margaret Solon, Karin Reif

Toxicol Sci· July 2016

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Depletion of major pathogenic cells in asthma by targeting CRTh2.
Tao Huang, Meredith Hazen, Yonglei Shang, Meijuan Zhou, Xiumin Wu, Karin Reif

JCI Insight· May 2016

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Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Wendy B Young, James Barbosa, Peter Blomgren, Meire C Bremer, James J Crawford, Karin Reif

Bioorg Med Chem Lett· January 2016

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Potent and selective Bruton's tyrosine kinase inhibitors: discovery of GDC-0834.
Wendy B Young, James Barbosa, Peter Blomgren, Meire C Bremer, James J Crawford, Karin Reif

Bioorg Med Chem Lett· March 2015

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Identification of GNE-293, a potent and selective PI3Kδ inhibitor: navigating in vitro genotoxicity while improving potency and selectivity.
Brian S Safina, Zachary K Sweeney, Jun Li, Bryan K Chan, Angelina Bisconte, Karin Reif

Bioorg Med Chem Lett· September 2013

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Potent and selective inhibitors of PI3Kδ: obtaining isoform selectivity from the affinity pocket and tryptophan shelf.
Daniel P Sutherlin, Stewart Baker, Angelina Bisconte, Paul M Blaney, Anthony Brown, Karin Reif

Bioorg Med Chem Lett· July 2012

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Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.
Brian S Safina, Stewart Baker, Matt Baumgardner, Paul M Blaney, Bryan K Chan, Karin Reif

J Med Chem· June 2012

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Antiarthritis effect of a novel Bruton's tyrosine kinase (BTK) inhibitor in rat collagen-induced arthritis and mechanism-based pharmacokinetic/pharmacodynamic modeling: relationships between inhibition of BTK phosphorylation and efficacy.
Lichuan Liu, Julie Di Paolo, Jim Barbosa, Hong Rong, Karin Reif

J Pharmacol Exp Ther· July 2011

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Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis.
Julie A Di Paolo, Tao Huang, Mercedesz Balazs, James Barbosa, Kai H Barck, Karin Reif

Nat Chem Biol· January 2011

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CD200R1 agonist attenuates mechanisms of chronic disease in a murine model of multiple sclerosis.
Yingru Liu, Yoshio Bando, David Vargas-Lowy, Wassim Elyaman, Samia J Khoury, Karin Reif

J Neurosci· February 2010

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Cutting edge: differential roles for phosphoinositide 3-kinases, p110gamma and p110delta, in lymphocyte chemotaxis and homing.
Karin Reif, Klaus Okkenhaug, Takehiko Sasaki, Joseph M Penninger, Bart Vanhaesebroeck

J Immunol· August 2004

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The CDM protein DOCK2 in lymphocyte migration.
Karin Reif, Jason Cyster

Trends Cell Biol· August 2002

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Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.
Karin Reif, Eric H Ekland, Lars Ohl, Hideki Nakano, Martin Lipp

Nature· March 2002

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